Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(12), P. 24 - 24
Published: Oct. 17, 2024
To
explore
the
application
and
potential
ferroptosis
mechanisms
of
sonodynamic
therapy
(SDT)
using
titanium
dioxide
nanoparticles
(TiO2-NPs)
as
sonosensitizers
for
prevention
posterior
capsule
opacification
(PCO).
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
discovered
in
2012.
Noninvasive
treatments
regulating
ferroptosis
are
important
for
wide
range
diseases.
Among
the
noninvasive
treatments,
sonodynamic
therapy
(SDT)
has
become
promising
due
to
its
strong
tissue
penetration
and
few
side
effects.
In
recent
years,
targeted
drug
delivery
platforms
constructed
on
basis
SDT
have
provided
an
efficient
mode
regulation
ferroptosis.
Based
latest
research
reports,
this
Perspective
introduces
basic
mechanism
influencing
factors
therapeutic
effects,
elucidates
significance
ferroptosis-targeted
SDT,
summarizes
studies
through
different
pathways.
We
also
present
innovative
composite
ultrasound-responsive
platforms.
Finally,
brief
summary
outlook
based
current
presented.
Advanced Therapeutics,
Journal Year:
2023,
Volume and Issue:
6(12)
Published: Sept. 16, 2023
Abstract
Sonodynamic
therapy
(SDT)
is
a
rapidly
developing,
safe,
and
noninvasive
method
for
tumor
treatment.
SDT
relies
on
ultrasound
to
stimulate
the
activity
of
sonosensitizers,
induce
production
many
reactive
oxygen
species
(ROS),
mediate
cell
death.
The
complex
microenvironment
(TME)
basis
tumorigenesis
development.
characteristics
TME,
which
are
different
from
those
normal
tissue,
essential
factors
in
regulating
response
antitumor
therapy.
therapeutic
effect
affected
by
TME.
Therefore,
study
multifunctional
sonosensitizers
related
TME
future
direction
enhance
efficacy
treating
tumors.
This
review
summarizes
that
regulate
it,
its
role
sonosensitizers.
It
introduces
strategies
enhancing
exploiting
highlights
prospects
combination
tumors
based
With
this
paper,
it
hoped
provide
research
improving
promoting
clinical
translation
future.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
19(3)
Published: Dec. 27, 2023
Abstract
Metal
complexes
represented
by
platinum
play
a
very
important
role
in
cancer
treatment
due
to
their
diverse
chemical
structures
and
anti‐tumor
activities.
Recently,
ferroptosis
has
emerged
as
newly
occurring
cell
death
form
the
process.
It
been
reported
that
metal
could
inhibit
proliferation
metastasis
of
tumors
combat
chemotherapy
resistance
targeting
ferroptosis.
In
this
review,
we
briefly
describe
fundamental
process
for
tumor
suppression
triggering
immune
responses.
We
summarize
recent
developments
on
induce
Finally,
outline
prospects
application
based
associated
problems
need
be
solved,
discussed
other
potential
research
directions
complexes.