Impact of Rhenium(I)-Diselenoether Compound on Cell Adhesion, Migration, Invasion Capacities, and MMP-2 Release in MDA-MB-231 Breast Cancer Cells DOI Creative Commons

PHILIPPE COLLERY,

Didier Desmaële, Adhikesavan Harikrishnan

et al.

Anticancer Research, Journal Year: 2024, Volume and Issue: 45(1), P. 73 - 79

Published: Dec. 30, 2024

Background/Aim: Organometallic complexes can decrease adhesion, migration, invasion of cancer cells, mainly through regulation the extracellular matrix and therefore act against metastases. The aim was to investigate anti-invasive properties a rhenium-based metal compound, rhenium(I)-diselenoether (Re-diSe) its effects on metalloproteinase MMP-2, key player in metastatic processes, cultured MDA-MB231 triple-negative breast cells. Materials Methods: Matrigel utilized assess cell adhesion matrix. Migration capacity evaluated wound healing assay, while assays were conducted using transwell assay by crystal violet dye. MMP-2 levels quantified medium fluorometric kit assay. Cells exposed increasing concentrations drug (5, 10, 20, 50 100 μM). Three time points exposure cells investigated (48, 96 120 h). Results: Re-diSe exhibited effectiveness even at doses as low 5 or 10 μM all biological assays. h significantly improved effect comparison with 48 h. Conclusion: results highlight impact

Language: Английский

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies DOI Creative Commons

Wei‐Fang Zuo,

Qiwen Pang, Xinyu Zhu

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Sept. 4, 2024

Language: Английский

Citations

11
Ruthenium(ii)–Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance DOI

Mengdi Lv,

Yue Zheng,

Xiangyu Dai

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Chemoresistance remains an arduous challenge in oncology, but ferroptosis shows potential for overcoming it by stimulating the immune system. Herein, a novel high-performance ruthenium(II)-based arene complex [Ru(η

Language: Английский

Citations

4
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers DOI
Zhennan Yuan, Yuqin Wang,

Boyu Qin

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101160 - 101160

Published: Oct. 17, 2024

Language: Английский

Citations

3
Impact of Rhenium(I)-Diselenoether Compound on Cell Adhesion, Migration, Invasion Capacities, and MMP-2 Release in MDA-MB-231 Breast Cancer Cells DOI Creative Commons

PHILIPPE COLLERY,

Didier Desmaële, Adhikesavan Harikrishnan

et al.

Anticancer Research, Journal Year: 2024, Volume and Issue: 45(1), P. 73 - 79

Published: Dec. 30, 2024

Background/Aim: Organometallic complexes can decrease adhesion, migration, invasion of cancer cells, mainly through regulation the extracellular matrix and therefore act against metastases. The aim was to investigate anti-invasive properties a rhenium-based metal compound, rhenium(I)-diselenoether (Re-diSe) its effects on metalloproteinase MMP-2, key player in metastatic processes, cultured MDA-MB231 triple-negative breast cells. Materials Methods: Matrigel utilized assess cell adhesion matrix. Migration capacity evaluated wound healing assay, while assays were conducted using transwell assay by crystal violet dye. MMP-2 levels quantified medium fluorometric kit assay. Cells exposed increasing concentrations drug (5, 10, 20, 50 100 μM). Three time points exposure cells investigated (48, 96 120 h). Results: Re-diSe exhibited effectiveness even at doses as low 5 or 10 μM all biological assays. h significantly improved effect comparison with 48 h. Conclusion: results highlight impact

Language: Английский

Citations

0