Time‐Dependent Electrical Active and Ultrasound‐Responsive Calcium Titanate Implant Coating with Immunomodulation, Osteogenesis, and Customized Antibacterial Activity

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Surgical site infection and insufficient osseointegration are notable risks factors associated with oral implant surgery. In this study, the development of a polarized calcium titanate (CT-P) coating for titanium surfaces is proposed as solution to these problems. The generated electrical stimulation (ES) can inhibit pro-inflammatory M1-type macrophage polarization promote anti-inflammatory M2-type polarization, resulting in favorable bone immunomodulation. ES by match physiological potential that will change during repair, thereby promoting vivo. addition, system also achieve on-demand antibacterial activity, mainly depending on CT-P responding ultrasound (US) irradiation produce reactive oxygen species (ROS) remove Staphylococcus aureus (S. aureus) surface implant. conclusion, work provides valuable insights clinical application highly efficient electroactive coatings, well novel solutions selective treatment bacterial infections surgical area.

Language: Английский

---

Ultrasound-Mediated Piezoelectric Microneedles Regulating Macrophage Polarization and Remodeling Pathological Microenvironment for Lymphedema Improvement

ACS Nano, Journal Year: 2024, Volume and Issue: 19(1), P. 1447 - 1462

Published: Dec. 30, 2024

Lymphedema, a severe and complex inflammatory disease caused by lymphatic system insufficiency impeded drainage that causes an enormous physical psychological burden on patients may even lead to death, has long been challenging issue in the medical field. Clinically, conventional approaches including surgical treatment conservative have employed for lymphedema therapy, but their curative effect is still unsatisfactory because of high operational difficulty, cost, long-term reliance. In this study, novel kind piezoelectric microneedle driven ultrasound (US) proposed regulate macrophage polarization remodel pathological microenvironment noninvasive manner, thereby promoting regeneration improving lymphedema. US-mediated microneedles can significantly enhance anti-inflammatory M2-type macrophages while suppressing pro-inflammatory M1-type vitro. Enhancements M2 trigger increased secretion factors (e.g., IL-4, IL-10, Arg-1) promote remodeling immune rebalancing. mouse-tail model, higher proportion marker CD206 observed accompanied normal lymphangiogenesis subsiding following with US stimulation treatment. Additionally, based RNA sequencing mechanistic investigation, it was revealed activate signaling pathways related responses improve function, consequently alleviating Collectively, study provides new strategy therapy drug-free manner as well potent tool manipulate other immunological diseases.

Language: Английский

---

Durability of antimicrobial agent on nanofiber: A collective review from 2018 to 2022

Journal of Industrial and Engineering Chemistry, Journal Year: 2023, Volume and Issue: 130, P. 1 - 24

Published: Sept. 22, 2023

Language: Английский

---

A reduction-driven directed aggregation strategy for fabricating stretchable conductive core-sheath fibers in wearable electronics

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 480, P. 148058 - 148058

Published: Dec. 14, 2023

Language: Английский

---

Sternal Wound Reconstruction Following Deep Sternal Wound Infection: Past, Present and Future: A Literature Review

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(11), P. 361 - 361

Published: Nov. 7, 2024

This literature review critically examines the historical, current, and prospective dimensions of sternal wound reconstruction in specific context deep infection (DSWI), aiming to enhance patient outcomes optimise surgical techniques. Preventive measures, including prophylactic antibiotic administration site preparation, are crucial reducing incidence DSWI. Effective management necessitates a multidisciplinary approach encompassing debridement, drainage, sternum repair utilising diverse procedures conjunction with therapy. Traditional approaches managing DSWI involved closed irrigation drainage While these methods exhibited certain advantages, they also limitations varying degrees success. The current care paradigms emphasise interventions like suction irrigation, vacuum-assisted closure, flap reconstruction. Future advancements techniques technology hold promise for further enhancing separates emphasises distinct roles prophylaxis, treatment, reconstructive techniques, each relevant specifically management. Collaborative efforts between cardiac plastic surgeons, supported by ongoing research innovation, indispensable advance restoration achieve superior terms welfare, morbidity mortality reduction, efficacy.

Language: Английский

---

Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, organs. Known its highly oriented hierarchical structure, collagen in natural bones produces local electrical signals to stimulate osteoblasts promote bone formation, inspiring application of orthopedic medicine. Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, other signaling pathways. This review thus focuses on discussing pioneering applications diagnosis treatment diseases, aiming offer valuable insights advancing next‐generation medical technologies. Beginning an introduction principles various materials, this paper delves into mechanisms which accelerated osteogenesis. A comprehensive overview devices, systems enhancing tissue repair, alleviating inflammation at infection sites, monitoring health is then provided, respectively. Finally, major challenges faced conditions are thoroughly discussed, along a critical outlook future development trends.

Language: Английский

---

Evaluation of sustained drug release performance and osteoinduction of magnetron-sputtered tantalum-coated titanium dioxide nanotubes

RSC Advances, Journal Year: 2024, Volume and Issue: 14(6), P. 3698 - 3711

Published: Jan. 1, 2024

Schematic illustration of the preparation TNT-Ta with sustained drug release property and osteogenic ability.

Language: Английский

---

Ferro-catalysis bioelectronics: Progress and prospects

Nano Energy, Journal Year: 2023, Volume and Issue: 120, P. 109059 - 109059

Published: Nov. 4, 2023

Language: Английский

---