3D micro-nano printing technology as a transformative tool apply for microneedle drug delivery DOI
Xiaolu Han,

Yuanke Yang,

Yaying Xu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105709 - 105709

Published: April 25, 2024

Language: Английский

The Roles of Exosome-Derived microRNAs in Cardiac Fibrosis DOI Creative Commons

Xinyuan Tang,

Mingyang Leng,

Wenyue Tang

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1199 - 1199

Published: March 7, 2024

Cardiovascular disease (CVD) stands as the foremost cause of patient mortality, and lack early diagnosis defined treatment targets significantly contributes to suboptimal prevention management CVD. Myocardial fibrosis (MF) is not only a complex pathogenic process with no effective currently available but also exerts detrimental effects on progression various cardiovascular diseases, thereby escalating their mortality rates. Exosomes are nanoscale biocommunication vehicles that facilitate intercellular communication by transporting bioactive substances, such nucleic acids proteins, from specific cell types. Numerous studies have firmly established microRNAs (miRNAs), non-coding RNAs, wield post-transcriptional regulatory mechanisms exhibit close associations CVDs, including coronary heart (CHD), atrial fibrillation (AF), failure (HF). MiRNAs hold significant promise in diseases. In this review, we provide concise introduction biological attributes exosomes exosomal miRNAs. We explore roles distinct cell-derived miRNAs context myocardial fibrosis. These findings underscore pivotal role cardiac emphasize potential biotherapies drug delivery vectors for treatment.

Language: Английский

Citations

7
Exosomes based strategies for cardiovascular diseases: Opportunities and challenges DOI
Hang Li,

Jun Zhang,

Mingyue Tan

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122544 - 122544

Published: March 31, 2024

Language: Английский

Citations

7
State-of-the-art strategies to enhance the mechanical properties of microneedles DOI
Xinyu Zhang,

Chunxian Zhou,

Tianxiang Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124547 - 124547

Published: Aug. 2, 2024

Language: Английский

Citations

7
A fibrin patch loaded with mesenchymal stem cells-derived exosomes improves cardiac functions after myocardial infarction DOI Creative Commons
Xiaoyu Wang, Jingjing Wang, Yanxia Zhang

et al.

Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 59, P. 100775 - 100775

Published: Feb. 23, 2024

Myocardial infarction (MI) is a typical cardiovascular disease, causing disability and death worldwide. Exosomes secreted by mesenchymal stem cells (MSCs) showed remarkable therapeutic effects in MI restoring cardiac function. However, the application of exosomes remains challenge because their low residence rate infarcted myocardium. Herein, fibrin-based patch was prepared to deliver MSCs-derived heart using an mouse model, aiming at improvement functions. The fibrin optimized for size minimize mortality rate. composite sustained release vitro could improve retention heart, inhibiting fibrosis improving functions vivo. Therefore, this combination natural biomaterial-based may have promising clinical translational potential treatment.

Language: Английский

Citations

6
3D micro-nano printing technology as a transformative tool apply for microneedle drug delivery DOI
Xiaolu Han,

Yuanke Yang,

Yaying Xu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105709 - 105709

Published: April 25, 2024

Language: Английский

Citations

6