ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine DOI

Zhengyang Quan,

Sa Wang,

Huanhuan Xie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.

Language: Английский

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications DOI Creative Commons
Meng Sun,

Jiani Yang,

Yueyun Fan

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(32)

Published: Sept. 25, 2023

Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics artificially acquired advantages. However, limited targeting ability, insufficient production yield, low drug-loading capability simplex EVs greatly hindered development clinical translation. Therefore, establishment multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability flexibility has become key expanding practical application EVs. This timely review summarizes current progress HMNVs biomedical applications. Different preparation strategies including physical, chemical, chimera approaches are first discussed. then individually describes diverse types based on homologous or heterologous cell substances, a fusion liposome, well bacterial membrane. Subsequently, specific emphasis is placed highlight applications toward various diseases representative examples. Finally, ongoing challenges prospects currently developed translational briefly presented. will not only stimulate broad interest among researchers from disciplines but also provide valuable insights promising nanoplatforms precision medicine.

Language: Английский

Citations

36
CD-MOFs: From preparation to drug delivery and therapeutic application DOI

Yanxue Si,

Huize Luo, Pai Zhang

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121424 - 121424

Published: Sept. 20, 2023

Language: Английский

Citations

34
Precisely Inhibiting Excessive Intestinal Epithelial Cell Apoptosis to Efficiently Treat Inflammatory Bowel Disease with Oral Pifithrin‐α Embedded Nanomedicine (OPEN) DOI Open Access
Mingyuan Wang, Qiong Huang, Min Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Sept. 25, 2023

The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life quality patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis, disrupting gut barrier, colonizing harmful bacteria, and initiating persistent inflammation. current therapeutic approaches that reduce inflammation are limited. Although can be treated significantly by directly preventing IEC achieving this approach remains challenging. Accordingly, authors first develop an oral pifithrin-α (PFTα, a highly specific p53 inhibitor) embedded nanomedicine (OPEN) effectively treat inhibiting apoptosis. As major hub for various stressors, is central determinant fate, its inhibition tailored OPEN precisely inhibit off-target inactivation resulting from PFTα entry into bloodstream. Subsequently, it persistently targets lesions with high specificity pathological events caused Eventually, exerts significant curative effect compared clinical first-line drugs 5-aminosalicylic acid (5-ASA) dexamethasone (DEX). Consequently, strategy provides new insights comprehensive therapy.

Language: Английский

Citations

33
Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis DOI Open Access

Menghang Zu,

Ga Liu,

Haiting Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: July 29, 2024

Abstract The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut secrete abundant extracellular vesicles (Gm‐EVs), which play a critical role bacteria‐to‐bacteria and bacteria‐to‐host communications. Herein, intestinal are trained using tea leaf lipid/pluronic F127‐coated curcumin nanocrystals (CN@Lp 127 s), can maintain stability during transit through the gastrointestinal tract. Compared FMT, Gm‐EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring barrier function, rebalancing microbiota. Strikingly, obtained CN@Lp ‐trained exhibit superior therapeutic effect on compared to groups receiving FMT mice, mice. Oral administration of not only alleviates inflammation, promotes mucosal repair, regulates gut but also purine metabolism decrease uric acid level, resulting robust improvement UC. This study demonstrates efficacy nanomedicine‐trained regulating immune microenvironment, microbiota, colon. These EVs provide an alternative platform replace as for

Language: Английский

Citations

14
Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease DOI

Wanyue Fu,

Lingling Xu,

Z Chen

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 149 - 179

Published: Sept. 27, 2023

Language: Английский

Citations

22
Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome DOI

Yubiao Huang,

Jiaqi Xu,

Ge Sun

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122822 - 122822

Published: Sept. 12, 2024

Language: Английский

Citations

8
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models DOI
Lingjie Kong, Siyan Chen,

Shenghao Huang

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(4), P. 541 - 562

Published: Feb. 12, 2024

Language: Английский

Citations

7
Scale‐Up Preparation of Manganese‐Iron Prussian Blue Nanozymes as Potent Oral Nanomedicines for Acute Ulcerative Colitis DOI

Chengyun Hu,

Yuan Xue,

Ronghua Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 6, 2024

Abstract Prussian blue (PB) nanozymes are demonstrated as effective therapeutics for ulcerative colitis (UC), yet an unmet practical challenge remains in the scalable production of these and uncertainty over their efficacy. With a novel approach, series porous manganese‐iron PB (MnPB) colloids, which shown to be efficient scavengers reactive oxygen species (ROS) including hydroxyl radical, superoxide anion, hydrogen peroxide, prepared. In vitro cellular experiments confirm capability nanozyme protect cells from ROS attack. vivo, administration MnPB through gavage at dosage 10 mg kg −1 per day three doses total potently ameliorates pathological symptoms acute UC murine model, resulting mitigated inflammatory responses improved viability rate. Significantly, produced large scale can achieved unprecedented yield weighting ≈11 g batch reaction, demonstrating comparable anti‐ROS activities treatment efficacy its small‐scale counterpart. This work represents first demonstration scale‐up preparation analog without compromising efficacy, laying foundation further testing on larger animals promising clinical translation.

Language: Английский

Citations

6
Β-Cyclodextrin-based materials for 3D printing, cancer therapy, tissue engineering, and wound healing DOI
Malairaj Sathuvan, Sunhong Min, Karthikeyan Narayanan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157272 - 157272

Published: Oct. 1, 2024

Language: Английский

Citations

4
Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends DOI Creative Commons
Hongyu Jiang, Bo Shao, Hongda Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited references, keywords, thereby mapping intellectual structure emerging field. analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers 5,459 institutions 287 countries/regions. global publication numbers exhibited an upward trend, particularly last decade, with China leading as top publishing country Chinese Academy Sciences foremost institution. Dr. Xiao Bo is prominent figure advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, medicine, seen influential mainly concentrated targeted nanoparticles treatment IBD. Keyword revealed that hotspots include delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, nanovesicles. study offers overview landscape, emphasizing rapid growth increasing complexity this It identifies key trends, including efforts enhance precision, efficacy, safety applications. Emerging directions highlighted crucial further progress evolving area.

Language: Английский

Citations

0