Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 339 - 353

Published: Feb. 1, 2024

Language: Английский

---

Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy

Language: Английский

---

Smart bionanomaterials for treatment and diagnosis of inflammatory bowel disease

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Inflammatory bowel disease (IBD) encompasses a group of chronic inflammatory disorders that affect the gastrointestinal tract, with Crohn’s and ulcerative colitis being primary subtypes. Diagnosis treatment IBD are challenging due to their unknown etiology complex pathology. Smart bionanomaterials, which biocompatible nanometer-sized materials respond external stimuli, can be used in diagnosis diseases. In context IBD, these deliver drugs, primarily aminosalicylates, corticosteroids, as well live probiotics inflamed parts intestine, specific focus on colon. The controlled release drugs triggered by conditions present IBD-affected such inflammation, anaerobic environment, neutral pH, gut microbiota. This article provides an overview use smart including hydrogels, nanoparticles, nanofibers, hybrid systems. It discusses manufacturing process ability active ingredients response various temperature, reactive oxygen species, magnetic field, biomolecules, for IBD. We also describe probiotics, have been genetically engineered recognize stimuli synthesize recombinant proteins qualitative or quantitative exploited diagnostic applications, some examples already developed. bionanomaterials offer several advantages, encapsulation, targeted delivery, responsiveness release. These features make them valuable adjunct tool

Language: Английский

---

Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

---

Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 6, 2024

Ulcerative colitis (UC) is defined by persistent inflammatory processes within the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in their ability to address oxidative stress, inflammation, barrier function restoration, and modulation gut microbiota a coordinated manner maintain intestinal homeostasis.

Language: Английский

---

Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139114 - 139114

Published: Jan. 2, 2025

Language: Английский

---

Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited references, keywords, thereby mapping intellectual structure emerging field. analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers 5,459 institutions 287 countries/regions. global publication numbers exhibited an upward trend, particularly last decade, with China leading as top publishing country Chinese Academy Sciences foremost institution. Dr. Xiao Bo is prominent figure advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, medicine, seen influential mainly concentrated targeted nanoparticles treatment IBD. Keyword revealed that hotspots include delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, nanovesicles. study offers overview landscape, emphasizing rapid growth increasing complexity this It identifies key trends, including efforts enhance precision, efficacy, safety applications. Emerging directions highlighted crucial further progress evolving area.

Language: Английский

---

Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 22, 2025

Background Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon. Several preclinical studies investigated beneficial effects atorvastatin in colitis. Activation sphingosine 1 phosphate (S1P)/ tumor necrosis factor-alpha (TNF- α )/ interleukin-6 (IL-6) pathways has been confirmed pathogenesis UC and proved efficacy on these pathways. Aim To investigate role S1P/TNF- /IL-6 pathway UC. Methods Patients with mild to moderate were allocated into two groups this pilot study. For 6 months, Group (placebo group) received both placebo g mesalamine three times daily (t.i.d.). 2, (the 80 mg once t.i.d. A gastroenterologist evaluated patients’ severity by partial Mayo score index (PMS). Serum IL-6, S1P, TNF- , nitric oxide (NO), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fecal calprotectin measured before after treatment. Short Form 36 questionnaire (SF-36) was also assessed. clinical response defined as decline rectal bleeding sub at least one point, decrease PMS points. Clinical remission less than 2 absence any single greater 1. Primary outcome Decreased improved quality life. Secondary Change level biomarkers. Results Compared group ( n = 24), 23) exhibited significant IL-6 p 0.001), S1P 0.0001), 0.003), NO CRP 0.015), ESR 0.012), 0.013), 0.0003), SF-36 0.006). In group, 83.33% 20/24) for PMS, 45.83% 11/24). 91.3% 21/23), 60.8% 14/23) PMS. Conclusion Atorvastatin could be an adjunctive therapy patients trial registration https://www.clinicaltrials.gov/ Identifier NCT05561062.

Language: Английский

---

Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that has long plagued patients. Herein, an innovative oral treatment strategy for IBD proposed, which utilizes calcium alginate hydrogel as carrier to deliver Co3O4 nanocages loaded with total glucosides of paeony (TGP) into the body. This design ingeniously exploits protective properties outer layer ensure enzyme not prematurely degraded when passing through acidic gastric juice. However, upon reaching inflamed intestinal site, overexpressed H2O2 there mixes specific solution, causing degrade and release Co3O4@TGP. These negatively charged nanozymes can precisely recognize accumulate in colonic tissue, achieving targeted therapy their unique charge characteristics. More importantly, itself possesses excellent catalytic activity, effectively consuming excess at site inflammation degrading 10 nm small particles process, while simultaneously releasing TGP. Together, they exert dual effects scavenging reactive oxygen species (ROS) anti-inflammation. Its therapeutic mechanism involves fine regulation expression key proteins such TLR7, MYD88, GAPDH, well effective inhibition NF-κB signaling pathway. series actions only reduces various pro-inflammatory cytokines (such TNF-α, IL-18, IL-1β, IL-6, HMGB1) but also promotes production anti-inflammatory cytokine IL-10, thereby maintaining integrity barrier. research achievement opens up novel path colitis.

Language: Английский

---

A Cerium Nanocluster for Effective Alleviation of Inflammatory Bowel Disease by Scavenging RONS and Regulating Gut Microbiome

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101705 - 101705

Published: March 1, 2025

Language: Английский

---