Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 29, 2024
Abstract
Endothelium,
the
lining
in
this
blood
vessel,
orchestrates
three
main
critical
functions
such
as
protecting
components,
modulating
of
hemostasis
by
secreting
various
inhibitors,
and
directing
clot
digestion
(fibrinolysis)
activating
tissue
plasminogen
activator.
No
other
surface
can
perform
these
tasks;
thus,
contact
blood‐contacting
medical
devices
inevitably
leads
to
activation
coagulation,
often
causing
device
failure,
thromboembolic
complications.
This
perspective,
first,
discusses
biological
mechanisms
coagulation
highlights
efforts
advanced
coatings
recapitulate
one
characteristic
endothelium,
hereafter
single
endothelium
noting
necessity
synergistic
integration
its
functions.
Subsequently,
it
is
emphasized
that
overcome
challenges
compatibility
an
endothelium‐mimicking
system
needed,
proposing
a
synergy
bottom‐up
synthetic
biology,
particularly
cells,
with
passive‐
bioactive
coatings.
Such
holds
promise
for
developing
biomaterials
capable
recapitulating
endothelial
functions,
thereby
enhancing
hemocompatibility
performance
devices.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Bioactive
surfaces
play
a
pivotal
role
in
biomedical
applications
by
enabling
precise
biological
interactions
through
immobilized
functional
molecules.
However,
their
performance
is
often
hindered
nonspecific
protein
adsorption
and
cell
adhesion.
Antifouling
polymer
coatings
have
emerged
as
an
effective
solution,
creating
hydration
barriers
to
preserve
functionality
reduce
biofouling.
This
review
provides
overview
of
the
recent
advances
development
antifouling
for
bioactive
surfaces,
with
particular
focus
on
nonionic
polymers,
such
polyethylene
glycol
(PEG),
zwitterionic
polymers
like
poly(2-methacryloyloxyethyl
phosphorylcholine)
(PMPC).
Among
them,
unique
charge-balanced
structures,
exhibit
exceptional
hydration,
resistance,
stability,
making
them
particularly
promising
applications.
In
addition,
key
these
including
use
anticoagulant
materials,
antibacterial
coatings,
biosensor
interfaces,
are
also
discussed.
The
discussion
concludes
address
field's
challenges
future
directions,
highlighting
need
innovative
materials
that
balance
properties,
biocompatibility,
long-term
stability
both
clinical
industrial
use.
aims
latest
advancements
provide
insights
into
optimizing
multifunctional
meet
evolving
dynamic
demands
field.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Biomedical
device-related
bacterial
infections
are
a
leading
cause
of
mortality,
and
traditional
antibiotics
contribute
to
resistance.
Various
surface
modification
strategies
have
been
explored,
but
effective
clinical
solutions
remain
limited.
This
study
introduces
novel
antibacterial
nanocoating
with
copper
nanoparticles
(CuNPs)
that
triggers
localized
nitric
oxide
(NO)
release.
The
multilayered
is
created
using
branched
polyethylenimine
(BPEI)
poly(acrylic
acid)
(PAA)
via
Layer-by-Layer
assembly
method.
CuNP-decorated
nanocoatings
formed
by
reducing
ions
coordinated
amine/carboxylic
acid
groups.
In
physiological
environment,
CuNPs
oxidize
Cu(I),
promoting
NO
release
from
endogenous
donors.
nanocoating's
thickness
adjustable
regulate
amount
flux.
optimal
for
against
Staphylococcus
aureus
Pseudomonas
aeruginosa
identified,
preventing
microbial
adhesion
biofilm
formation.
Importantly,
the
coating
remains
cytocompatible
due
minimal
CuNPs,
levels,
stable
properties
under
conditions.
International Materials Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 13, 2025
In
recent
years,
zwitterionic
materials
have
been
widely
used
in
biomedical
and
nanomedical
due
to
their
unique
structure
which
the
molecule
is
electrically
neutral
with
equal
positive
negative
charge.
This
kind
of
material
could
form
a
thick
hydration
layer
by
electrostatic
effect,
prevent
contamination,
show
wide
applications
life
science
fields,
such
as
resisting
non-specific
protein
adsorption,
biofilm,
thrombosis
formation,
so
on.
Most
importantly,
diversity
functional
groups
has
made
it
more
convenient
for
surface
modification
further
utilization,
creating
multifunctional
various
applications.
review
summarized
up-to-date
materials,
including
conventional
novel
structural
characteristics,
well
blood-contacting
implantable
devices,
antibacterial
coatings,
wound
dressings,
drug-targeted
carriers,
smart
wearable
biosensors,
especially
clinical
uses.
New
discoveries,
existing
challenges,
commercial
status
are
also
outlined,
future
opportunities
development
perspectives
new
biomaterials
demonstrated.
The
advancement
of
antithrombotic
materials
has
significantly
mitigated
the
thrombosis
issue
in
clinical
applications
involving
various
medical
implants.
Extensive
research
been
dedicated
over
past
few
decades
to
developing
blood-contacting
with
complete
resistance
thrombosis.
However,
despite
these
advancements,
risk
and
other
complications
persists
when
are
implanted
human
body.
Consequently,
modification
enhancement
remain
pivotal
21st-century
hemocompatibility
studies.
Previous
indicates
that
healthy
endothelial
cells
(ECs)
layer
is
uniquely
compatible
blood.
Inspired
by
bionics,
scientists
have
initiated
development
emulate
hemocompatible
properties
ECs
replicating
their
diverse
mechanisms.
This
review
elucidates
mechanisms
examines
endothelium-mimicking
developed
through
single,
dual-functional
multifunctional
strategies,
focusing
on
nitric
oxide
release,
fibrinolytic
function,
glycosaminoglycan
modification,
surface
topography
modification.
These
demonstrated
outstanding
performance.
Finally,
outlines
potential
future
directions
this
dynamic
field,
aiming
advance
materials.
