Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
3D
hierarchical
superstructures
(3DHSs)
are
key
products
of
nature's
evolution
and
have
raised
wide
interest.
However,
the
preparation
3DHSs
composed
building
blocks
with
different
structures
is
rarely
reported,
regulating
their
structural
parameters
challenging.
Herein,
a
simple
lecithin‐mediated
biomineralization
approach
reported
for
first
time
to
prepare
gold
0D
nucleus
1D
protruding
dendritic
spikes.
It
demonstrated
that
hydrophobic
complex
by
coordination
disulfiram
(DSF)
share
chloroauric
acid
forming
3DHSs.
Under
lecithin
mediation,
reduced
form
nucleus,
followed
spike
growth
through
reduction
complex.
The
prepared
possess
well‐defined
morphology
length
≈95
nm.
Notably,
density
systematically
manipulated
from
38.9%
74.3%
controlling
DSF
concentrations.
Moreover,
diameter
regulated
9.2
12.9
nm
selecting
concentrations
tune
process.
Finite‐difference
time‐domain
(FDTD)
simulations
reveal
spikes
“hot
spots”.
dense
structure
endows
sound
performance
in
surface‐enhanced
Raman
scattering
(SERS)
applications.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
98, P. 105856 - 105856
Published: June 8, 2024
The
pancreaticojejunostomy
device
is
an
exogenous
object
positioned
at
the
junction
between
jejunum
and
pancreatic
duct.
Bacteria
can
readily
settle
on
its
surface,
forming
a
biofilm,
potentially
leading
to
inflammation
anastomotic
site,
resulting
in
overgrowth
narrowing
of
anastomosis.
Furthermore,
biofilm
formation
inner
surface
lumen
obstruct
outflow
duct
fluid.
This
study
aims
develop
innovative
3D
coated
with
nano-silver
for
antibacterial
properties.
Chitosan
serves
as
coating
medium,
loaded
particles.
presence
confirmed
by
observing
morphology
elemental
composition
examining
drug
release
patterns
via
inductively
coupled
plasma
(ICP)
analysis.
Moreover,
we
validated
biocompatibility,
performance,
pancreas
toxicity
through
vitro
vivo
experiments.
results
affirm
successful
fabrication
this
device,
highlighting
efficacy,
well
satisfactory
biocompatibility
capabilities.
To
sum
up,
promising
prevent
infections
inflammatory
reactions
around
site
obstruction
caused
bacterial
biofilms.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
3D
hierarchical
superstructures
(3DHSs)
are
key
products
of
nature's
evolution
and
have
raised
wide
interest.
However,
the
preparation
3DHSs
composed
building
blocks
with
different
structures
is
rarely
reported,
regulating
their
structural
parameters
challenging.
Herein,
a
simple
lecithin‐mediated
biomineralization
approach
reported
for
first
time
to
prepare
gold
0D
nucleus
1D
protruding
dendritic
spikes.
It
demonstrated
that
hydrophobic
complex
by
coordination
disulfiram
(DSF)
share
chloroauric
acid
forming
3DHSs.
Under
lecithin
mediation,
reduced
form
nucleus,
followed
spike
growth
through
reduction
complex.
The
prepared
possess
well‐defined
morphology
length
≈95
nm.
Notably,
density
systematically
manipulated
from
38.9%
74.3%
controlling
DSF
concentrations.
Moreover,
diameter
regulated
9.2
12.9
nm
selecting
concentrations
tune
process.
Finite‐difference
time‐domain
(FDTD)
simulations
reveal
spikes
“hot
spots”.
dense
structure
endows
sound
performance
in
surface‐enhanced
Raman
scattering
(SERS)
applications.
