Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(27)

Published: April 24, 2024

A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), Ir(III) complexes have been constructed as single-molecule platform for synergistic photodynamic, photothermal, chemotherapy. The significant two-photon absorption at 808 nm remarkable singlet oxygen superoxide anion production in aqueous solution cells when exposed to infrared irradiation. most potent Ru(II) complex Ru7 enters tumor via the rare macropinocytosis, locates both nuclei mitochondria, regulates DNA-related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase RNA polymerase inhibition their effects photoactivated apoptosis, ferroptosis cleavage. exhibits high efficacy vivo malignant melanoma cisplatin-resistant non-small cell lung cancer tumors, a 100 % survival rate of mice, low toxicity normal residual rate. Such an activatable metal may contribute new generation single-molecule-based integrated diagnosis treatment address drug resistance clinical practice phototherapy large, deeply located solid tumors.

Language: Английский

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Effects of Photodynamic Therapy on Tumor Metabolism and Oxygenation Revealed by Fluorescence and Phosphorescence Lifetime Imaging

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1703 - 1703

Published: Jan. 30, 2024

This work was aimed at the complex analysis of metabolic and oxygen statuses tumors in vivo after photodynamic therapy (PDT). Studies were conducted on mouse tumor model using two types photosensitizers—chlorin e6-based drug Photoditazine predominantly targeted to vasculature genetically encoded photosensitizer KillerRed chromatin. Metabolism cells assessed by fluorescence lifetime redox-cofactor NAD(P)H, imaging. Oxygen content phosphorescence macro-imaging with an oxygen-sensitive probe. For visualization perfused microvasculature, optical coherence tomography-based angiography used. It found that PDT induces different alterations cellular metabolism, depending degree depletion. Moderate decrease case accompanied increase fraction free indicator glycolytic switch, early treatment. Severe hypoxia resulted from a vascular shutdown yielded persistent protein-bound (mitochondrial) NAD(P)H. These findings improve our understanding physiological mechanisms modes can be useful develop new approaches monitoring its efficacy.

Language: Английский

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Tumor microenvironment-responsive intelligent nanoplatform with oxygen self-supply for synergistic chemotherapy/photodynamic therapy/photothermal therapy against hypoxic tumors

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150523 - 150523

Published: March 24, 2024

Language: Английский

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Photodynamic therapy with NIR-II probes: review on state-of-the-art tools and strategies

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842

Published: Jan. 1, 2024

The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.

Language: Английский

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Design and biomedical application of Cr3+-doped gallate near-infrared persistent luminescence nanoprobes

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159183 - 159183

Published: Jan. 5, 2025

Language: Английский

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Living Microalgae‐Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract The combination of Ca 2+ overload and reactive oxygen species (ROS) production for cancer therapy offers a superior solution to the lack specificity in traditional antitumor strategies. However, current therapeutic platforms this strategy are primarily based on non‐targeting nanomaterials, leading undesirable off‐target side effects. Additionally, resistance ROS apoptosis induced by hypoxic tumor microenvironment (TME) further limits efficiency. Herein, magnetic microrobot living Spirulina Platensis (SP), which is coated with double layer Fe 3 O 4 nanoparticles (NPs) CaCO NPs. microrobots can accumulate regions under attraction, produces high‐Ca environment acidic TME facilitates ultrasound (US) stimulation. Meanwhile, sufficient (O 2 ) photosynthesis helps alleviate hypoxia promotes situ chlorophyll‐mediated photodynamic (PDT), coordinate induce cell apoptosis. With these unique properties, SP‐based offer promising microrobotics‐based accumulation production, contributing precise effective way treatment.

Language: Английский

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Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(15)

Published: Feb. 16, 2024

Abstract Developing Type‐I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type‐II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H 2 O reactive species (ROS). Herein, we propose electronic acceptor‐triggered photoinduced (a‐PET) strategy promoting separation electron‐hole pairs marriage two organic semiconducting a non‐fullerene scaffold‐based photosensitizer perylene diimide that significantly boost pathway produce plentiful ROS, especially, inducing 3.5‐fold 2.5‐fold amplification hydroxyl (OH⋅) superoxide (O − ⋅) generation. Systematic mechanism reveals intermolecular intramolecular charge after photoirradiation generate competent production radical ion promote process theoretical calculation ultrafast femtosecond transient absorption (fs‐TA) spectroscopy. By complementary diagnosis with photoacoustic imaging second near‐infrared fluorescence imaging, this as‐prepared nanoplatform exhibits fabulous photocytotoxicity in harsh hypoxic conditions terrific cancer revoked abilities living mice. We envision work will broaden insight into high‐efficiency phototheranostics.

Language: Английский

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Advances in Nanodynamic Therapy for Cancer Treatment

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

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Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17313 - 17322

Published: March 27, 2024

Glucose oxidase (Gox)-mediated starvation therapy offers a prospective advantage for malignancy treatment by interrupting the glucose supply to neoplastic cells. However, negative charge of Gox surface hinders its enrichment in tumor tissues. Furthermore, Gox-mediated infiltrates large amounts hydrogen peroxide (H2O2) surround normal tissues and exacerbate intracellular hypoxia. In this study, cascade-catalyzed nanogel (A-NE) was developed boost antitumor effects consumption cascade reactive release nitric oxide (NO) relieve First, cross-linking structure A-NE can serve as bioimmobilization Gox, ensuring stability while improving encapsulation efficiency. Then, efficiently inhibited proliferation cells generating H2O2. addition, covalent l-arginine (l-Arg) consumed H2O2 derived from decomposition generate NO, which augmented on metastatic tumors alleviating Eventually, both vivo vitro studies indicated that nanogels remarkably situ growth hindered recurrence, offering an alternative possibility clinical intervention.

Language: Английский

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Mitochondrial-Targeting Nanotrapper Captured Copper Ions to Alleviate Tumor Hypoxia for Amplified Photoimmunotherapy in Breast Cancer

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(2), P. 2166 - 2179

Published: Jan. 3, 2024

Hypoxia is a pervasive feature of solid tumors, which significantly limits the therapeutic effect photodynamic therapy (PDT) and further influences immunotherapy efficiency in breast cancer. However, transient alleviation tumor hypoxia fails to address underlying issue increased oxygen consumption, resulting from rapid proliferation cells. At present, studies have found that reduction consumption rate (OCR) by cytochrome C oxidase (COX) inhibition induced oxidative phosphorylation (OXHPOS) suppression was able solve proposed problem. Herein, we developed specific mitochondrial-targeting nanotrapper (I@MSN-Im-PEG), exhibited good copper chelating ability inhibit COX for reducing OCR. The results proved alleviated hypoxic microenvironment chelation mitochondria enhanced PDT vitro vivo. Meanwhile, improved photoimmunotherapy through both enhancing PDT-induced immunogenetic cell death (ICD) effects reversing Treg-mediated immune on 4T1 tumor-bearing mice. provided novel efficacious strategy enhance amplify

Language: Английский

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