Synthesis,
Journal Year:
2024,
Volume and Issue:
56(12), P. 1896 - 1904
Published: Feb. 22, 2024
Abstract
A
four-stage
method
for
the
synthesis
of
2H-imidazole-derived
push-pull
fluorophores
was
developed.
The
synthesized
compounds
are
characterized
by
absorption
in
range
250–400
nm,
emission
up
to
617
and
quantum
yields
99%.
Compounds
bearing
a
tetraphenylethylene
fragment
demonstrated
AIE
effect
solution
with
water
fraction
fw
>90%
significant
increase
intensity
20
times
22%.
ICT
states
these
were
confirmed
calculating
excited
state
dipole
moments
(>23D).
reported
synthetic
enables
fine-tuning
fluorescent
properties
developed
photoactive
molecular
systems
varying
donor
fragments.
obtained
could
be
particular
interest
design
organic
hybrid
materials.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4683 - 4703
Published: Jan. 31, 2024
Organic
fluorescent
molecules
with
emission
in
the
second
near-infrared
(NIR-II)
biological
window
have
aroused
increasing
investigation
cancer
phototheranostics.
Among
these
studies,
Benzobisthiadiazole
(BBT),
high
electron
affinity,
is
widely
utilized
as
acceptor
constructing
donor–acceptor–donor
(D-A-D)
structured
fluorophores
intensive
(NIR)
absorption
and
NIR-II
fluorescence.
Until
now,
numerous
BBT-based
dyes
been
employed
tumor
phototheranostics
due
to
their
exceptional
structure
tunability,
biocompatibility,
photophysical
properties.
This
review
systematically
overviews
research
progress
of
small
molecular
focuses
on
molecule
design
bioapplications.
First,
engineering
strategies
fine-tune
properties
high-performance
are
discussed
detail.
Then,
applications
optical
imaging
phototherapy
highlighted.
Finally,
current
challenges
future
prospects
also
summarized.
believed
significantly
promote
further
BBT-derived
for
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Recent
advances
have
been
made
in
second
near-infrared
(NIR-II)
fluorescence
bioimaging
and
many
related
applications
because
of
its
advantages
deep
penetration,
high
resolution,
minimal
invasiveness,
good
dynamic
visualization.
To
achieve
high-performance
NIR-II
bioimaging,
various
materials
probes
with
bright
emission
extensively
explored
the
past
few
years.
Among
these
emissive
materials,
conjugated
polymers
small
molecules
attracted
wide
interest
due
to
their
native
biosafety
tunable
optical
performance.
This
review
summarizes
brightness
strategies
available
for
highlights
recent
developments
bioimaging.
A
concise,
detailed
overview
molecular
design
regulatory
approaches
is
provided
terms
brightness,
long
wavelengths,
superior
imaging
Then,
typical
cases
which
are
used
as
introduced
by
providing
step-by-step
examples.
Finally,
current
problems
challenges
associated
accessing
briefly
discussed,
significance
future
prospects
proposed
offer
helpful
guidance
development
materials.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 17, 2024
Abstract
A
novel
hyper
cross-linked
polymer
of
2-Aminobenzoic
acid
(HCP-AA)
is
synthesized
for
the
adsorption
Cr
3+
and
CO
2
.
The
Brunauer–Emmett–Teller
surface
area
HCP-AA
615
m
g
−1
particle
size
0.5
nm
showed
maximum
lab
prepared
wastewater
(93%)
while
it
was
88%
real
industrial
wastewater.
It
might
be
due
to
electrostatic
interactions,
cation-π
lone
pair
interactions
cation
exchange
at
pH
7;
contact
time
8
min;
adsorbent
dose
0.8
g.
capacity
calculated
52.63
mg
chromium
metal
ions
optimum
conditions.
Freundlich
isotherm
studies
R
=
0.9273
value
best
fit
follows
pseudo
second
order
kinetic
model
(R
0.979).
found
non-spontaneous
exothermic
through
thermodynamic
calculations
like
Gibbs
free
energy
(ΔG),
enthalpy
change
(ΔH)
entropy
(ΔS)
were
6.58
kJ
mol
,
−
60.91
45.79
K
respectively.
1.39
mmol/g
with
quantity
31.1
cm
3
/g
(6.1
wt%)
273Kwhile
298
1.12
25.2
(5
wt%).
Overall,
study
suggests
that
carboxyl
(–COOH)
amino
(–NH
)
groups
may
actively
enhancing
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(6), P. 282 - 282
Published: May 30, 2024
Second
near-infrared
(NIR-II)
fluorescence
imaging
is
the
most
advanced
fidelity
method
with
extraordinary
penetration
depth,
signal-to-background
ratio,
biocompatibility,
and
targeting
ability.
It
currently
booming
in
medical
realm
to
diagnose
tumors
being
widely
applied
for
fluorescence-imaging-guided
tumor
surgery.
To
efficiently
execute
this
modern
modality,
scientists
have
designed
various
probes
capable
of
showing
NIR-II
window.
Here,
we
update
state-of-the-art
fluorescent
recent
literature,
including
indocyanine
green,
emissive
cyanine
dyes,
BODIPY
probes,
aggregation-induced
emission
fluorophores,
conjugated
polymers,
donor-acceptor-donor
carbon
nanotubes,
quantum
dots
imaging-guided
Furthermore,
point
out
that
new
materials
NIR-III
higher
wavelength
range
further
optimize
results
are
a
challenge
scientific
world.
In
general,
hope
review
will
serve
as
handbook
researchers
students
who
an
interest
developing
applying
surgery
it
expedite
clinical
translation
from
bench
bedside.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(25)
Published: April 26, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disorder
characterized
by
excessive
proliferation
of
rheumatoid
synovial
fibroblasts
(RASFs)
and
accumulation
inflammatory
cytokines.
Exploring
the
suppression
RASFs
modulation
RA
microenvironment
considered
comprehensive
strategy
for
RA.
In
this
work,
specifically
activated
nanoagents
(MAHI
NGs)
based
on
hypoxic
weakly
acidic
are
developed
to
achieve
second
near‐infrared
fluorescence
(NIR‐II
FL)/photoacoustic
(PA)
dual‐model
imaging‐guided
multi‐treatment.
Due
optimal
size,
MAHI
NGs
passively
accumulate
in
diseased
joint
region
undergo
rapid
responsive
degradation,
precisely
releasing
functionalized
components:
endogenous
melanin‐nanoparticles
(MNPs),
hydrogen
gas
(H
2
),
indocyanine
green
(ICG).
The
released
MNPs
play
crucial
role
ablating
within
through
photothermal
therapy
(PTT)
guided
accurate
PA
imaging.
However,
regional
hyperthermia
generated
PTT
may
exacerbate
reactive
oxygen
species
(ROS)
production
response
following
cell
lysis.
Remarkably,
under
microenvironment,
controlled
release
H
exhibits
precise
synergistic
antioxidant
anti‐inflammatory
effects
with
MNPs.
Moreover,
ICG,
dye
currently
approved
clinical
use,
possesses
excellent
NIR‐II
FL
imaging
properties
that
facilitate
diagnosis
deep
tissue
diseases
provide
right
time‐point
PTT.
Bulletin of the Korean Chemical Society,
Journal Year:
2024,
Volume and Issue:
45(5), P. 451 - 455
Published: March 10, 2024
Abstract
Amino‐single
benzene‐based
fluorophores
(SBBFs)
are
representative
small‐size
fluorescent
dyes
that
have
an
electron
push‐pull
structure
within
the
benzene
core.
In
this
work,
a
new
library
of
amino‐SBBFs,
which
trifluoroacetyl
moiety
at
electron‐pushing
amine
group
(named
SBBF‐TFA),
featuring
variety
methylamines,
dimethylamines,
as
well
acetyl.
To
explore
SBBF‐TFA
library,
we
conducted
(i)
synthesis,
(ii)
assessment
various
photophysical
properties
in
nine
different
types
organic/aqueous
solvents,
and
(iii)
evaluation
cytotoxicity
HeLa
cell
line.
We
believe
our
findings
provide
valuable
insights
for
advancing
novel
small‐molecule
probes
materials
with
diverse
applications
across
pharmacochemical
fields.
