A Simple and Rapid “Turn-On” Fluorescent Probe Based on Binuclear Schiff Base for Zn2+ and Its Application in Cell Imaging and Test Strips DOI Creative Commons
Jinghui Cheng,

Yi Li,

Zhiye Zhu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5850 - 5850

Published: Dec. 11, 2024

A series of colorful binuclear Schiff bases derived from the different diamine bridges including 1,2- ethylenediamine (bis-Et-SA, bis-Et-4-NEt2, bis-Et-5-NO2, bis-Et-Naph), 1,2-phenylenediamine (bis-Ph-SA, bis-Ph-4-NEt2, bis-Ph-5-NO2, bis-Ph-Naph), dicyano-1,2-ethenediamine (bis-CN-SA, bis-CN-4-NEt2, bis-CN-5-NO2, bis-CN-Naph) have been designed and prepared. The optical properties these base ligands were fully determined by UV–Vis absorption spectroscopy, fluorescence emission time-dependent-density functional theory (TD-DFT) calculations. inclusion D-A systems and/or π-extended in not only enables adjustable RGB light spectra (300~700 nm) but also yields high quantum efficiencies up to 0.84 MeCN solution. Then, with ESIPT (excited-state intramolecular proton transfer) property, analysis showed that probe bis-Et-SA bis-Ph-SA could recognize Zn2+ via “turn on” mode During detection process, demonstrate rapid response selectivity upon addition Zn2+. coordination oxygen atom nitrogen a tetrahedral geometry is confirmed Job’s plot, FT-IR, 1H NMR spectroscopy. In addition, paper test Hela cells successfully carried out detect Moreover, sensitivity much better than those containing one chelating unit [O^N^N^O].

Language: Английский

Regulating Charge Transfer in Cyanine Dyes: A Universal Methodology for Enhancing Cancer Phototherapeutic Efficacy DOI
Xueze Zhao, Jianjun Du, Wen Sun

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(17), P. 2582 - 2593

Published: Aug. 17, 2024

ConspectusDue to the advantages of spatiotemporal selectivity and inherent noninvasiveness, cancer phototherapy, which includes both photodynamic therapy (PDT) photothermal (PTT), has garnered significant attention in recent years as a promising treatment. Despite commendable progress this field, persistent challenges remain. In PDT, limitations dyes manifest low intersystem crossing (ISC) efficiency oxygen-dependent photoactivity, resulting unsatisfactory performance, particularly under hypoxic conditions. Similarly, PTT encounters consistent insufficiencies conversion (PCE) dyes. Additionally, suboptimal phototherapeutic efficacy often exhibits limited immune response. These factors collectively impose constraints on phototherapy oncological applications, leading tumor inhibition, recurrence, even metastasis.Unlike strategies that rely external assistance with complicated systems, manipulating excited-state deactivation pathways biocompatible offers universal way systematically address these challenges. Our group devoted considerable effort achieving goal. Account, we present discuss our journey optimizing energy-release through regulating molecular charge transfer based cyanine dyes, are renowned for their exceptional photophysical properties harmonious biocompatibility. The investigation begins introduction amino groups

Language: Английский

Citations

14
Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer DOI Creative Commons
Fen Liu, Qiang Kang, Hao Xiao

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as promising strategy for the treatment TNBC. This approach works selectively destroying tumor cells, releasing tumor-associated antigens, activating immune system, and effectively inhibiting proliferation metastasis. However, majority current phototheranostic approaches are hindered limited tissue penetration in first near-infrared (NIR-I) ultraviolet–visible (UV–Vis) regions. Additionally, due to lack specific subcellular targets, it may be difficult treat deep-seated lesions with ambiguous extensive boundaries caused TNBC metastases. Consequently, development effective, deep-penetrating, organelle-targeted phototheranostics essential enhancing outcomes work proposes novel molecular design NIR-II realize planar rigid conjugation alkyl chain functionalization. The di-hexaalkyl chains vertical configuration on donor (4H-cyclopenta[2,1-b:3,4-b'] dithiophene) shielding units (fluorene) introduced construct S-D-A-D-S type (IR-FCD). structure IR-FCD exhibits robust intramolecular charge transfer capability, lower band gap, enhanced photon absorption properties, significant steric hindrance from vertically arranged minimize non-radiative energy loss. By incorporating N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide at terminus elongated chain, followed self-assembly into DSPE-S-S-PEG2000, excitable (IR-FCD-Ts NPs) endoplasmic reticulum (ER) targeting capability were successfully synthesized imaging-guided photoimmunotherapy IR-FCD-Ts NPs demonstrate exceptional optical characteristics, maximum 1068 nm (extending 1300 nm) emission 1273 1700 nm), along high molar coefficient 2.76*104 L/mol·c 1064 aqueous solution. Under exposure laser irradiation, exhibit superior photothermal properties have potential photodynamic therapy. ER, thereby inducing ER stress significantly immunogenic cell death (ICD) triggers strong antitumor response inhibits metastasis

Language: Английский

Citations

1
Recent progress in organic carbon dot-based photosensitizers for photodynamic cancer therapy DOI
Nguyễn Văn Nghĩa, Hoang Long Pham, Xuan Truong Nguyen

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 230, P. 112359 - 112359

Published: July 27, 2024

Language: Английский

Citations

6
Advances in phototheranostic agents: From imaging to targeted therapy DOI

M. Samadzadeh,

Arezoo Khosravi, Atefeh Zarepour

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102516 - 102516

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hemicyanine-based fluorescent probes: Advancements in biomedical sensing and activity-based detection DOI
Saleh Muhammad,

Haroon Ahmad,

Yuqian Yan

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216602 - 216602

Published: March 14, 2025

Language: Английский

Citations

0
Recent Advances for Synthesis and Bioapplications of Polymethine Cyanines DOI
Ziyue Yang, Qihang Sun,

Luyang Ji

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Polymethine cyanine dyes have witnessed significant advancements in bioimaging and phototherapy due to their optical properties ease of modification. This review categorizes introduces typical synthesis Cy3, Cy5, Cy7 longer polymethine dyes, highlights organic‐specific in‐cell cyanines via the newly‐established pseudo‐trimerization method using a single exogenous precursor activatable by visible light, free radicals or reactive oxygen species. Further discussions delve into functionalization strategies structure‐activity relationships summarizes bioapplications fluorescence imaging, multimodal assisted diagnosis treatments, aiming unlock full potential scientific research clinical translation.

Language: Английский

Citations

0
Xanthene-Based NIR organic phototheranostics agents: Design strategies and biomedical applications DOI
Xiao‐Yun Ran, Yuanfeng Wei, Yanling Wu

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing biomedical applications.

Language: Английский

Citations

0
Synergism of rotary motor and twisted framework in NIR absorbing aza-BODIPY for photothermal-photodynamic therapy DOI

Yiming Zhang,

Lei Fan,

Chuang Du

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102547 - 102547

Published: Jan. 25, 2025

Language: Английский

Citations

0
3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions DOI Open Access

Asma Harun,

Nathaniel Bendele,

M. Khalil

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Fluorescence image-guided surgery (FIGS) offers high spatial resolution and real-time feedback but is limited by shallow tissue penetration autofluorescence from current clinically approved fluorophores. The near-infrared (NIR) spectrum, specifically the NIR-I (700-900 nm) NIR-II (950-1700 nm), addresses these limitations with deeper improved signal-to-noise ratios. However, biological barriers suboptimal optical performance under surgical conditions have hindered clinical translation of NIR-I/II nanoprobes. In vivo mouse models shown promise, do not replicate complex scenarios encountered during real-world surgeries. Existing tissue-mimicking phantoms used to evaluate imaging systems are useful fall short when assessing nanoprobes in environments. These often fail tumor microenvironment, limiting their predictive assessment. To overcome challenges, we propose developing tumor-mimicking phantom (TMPs) that integrate key features, such as tunable cell densities, -like nanoparticle concentrations, biologically relevant factors (pH, enzymes), light absorption components (hemoglobin), scattering (intralipid). TMPs enable more assessments nanoprobes, including profiling, margin delineation, ex thoracic on porcine lungs. can be further modulated closely match profiles tumors. Additionally, 3D bioprinting technology facilitates a high-throughput platform for screening realistic conditions. This approach will identify high-performing probes superior utility, bridging gap between preclinical findings applications, ensuring results extend beyond traditional studies. TOC

Language: Английский

Citations

0
Recent advances in photothermal nanomaterials for ophthalmic applications DOI Creative Commons

Jiayuan Zhuang,

Linhui Jia, Chenghao Li

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 16, P. 195 - 215

Published: Feb. 17, 2025

The human eye, with its remarkable resolution of up to 576 million pixels, grants us the ability perceive world astonishing accuracy. Despite this, over 2 billion people globally suffer from visual impairments or blindness, primarily because limitations current ophthalmic treatment technologies. This underscores an urgent need for more advanced therapeutic approaches effectively halt even reverse progression eye diseases. rapid advancement nanotechnology offers promising pathways development novel therapies. Notably, photothermal nanomaterials, particularly well-suited transparent tissues have emerged as a potential game changer. These materials enable precise and controllable therapy by manipulating distribution thermal field. Moreover, they extend beyond conventional boundaries therapy, achieving unparalleled effects through their diverse composite structures demonstrating enormous in promoting retinal drug delivery photoacoustic imaging. paper provides comprehensive summary structure-activity relationship between properties these nanomaterials innovative mechanisms. We review latest research on nanomaterial-based treatments various Additionally, we discuss challenges future perspectives this field, focus enhancing global health.

Language: Английский

Citations

0