Synthesis,
Journal Year:
2024,
Volume and Issue:
56(12), P. 1896 - 1904
Published: Feb. 22, 2024
Abstract
A
four-stage
method
for
the
synthesis
of
2H-imidazole-derived
push-pull
fluorophores
was
developed.
The
synthesized
compounds
are
characterized
by
absorption
in
range
250–400
nm,
emission
up
to
617
and
quantum
yields
99%.
Compounds
bearing
a
tetraphenylethylene
fragment
demonstrated
AIE
effect
solution
with
water
fraction
fw
>90%
significant
increase
intensity
20
times
22%.
ICT
states
these
were
confirmed
calculating
excited
state
dipole
moments
(>23D).
reported
synthetic
enables
fine-tuning
fluorescent
properties
developed
photoactive
molecular
systems
varying
donor
fragments.
obtained
could
be
particular
interest
design
organic
hybrid
materials.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(23), P. 29902 - 29916
Published: May 29, 2024
Metabolic
rewiring,
a
dynamic
metabolic
phenotype
switch,
confers
that
tumors
exist
and
proliferate
after
fitness
(or
preadaptation)
in
harsh
environmental
conditions.
Glycolysis
deprivation
was
considered
to
be
tumor's
Achilles
heel.
However,
configuration
can
flexibly
retune
the
mitochondrial
ability
when
glycolysis
is
scared,
potentially
resulting
more
aggressive
clones.
To
address
challenge
of
reprogramming,
an
antiglycolytic
nanoparticle
(GRPP
NP)
containing
novel
mitochondrial-targeted
reactive
oxygen
species
(ROS)
generator
(diIR780)
prepared
hijack
glucose
regulate
mitochondria,
thus
completely
eliminating
tumorigenic
energy
sources.
In
this
process,
GRPP
NPs@diIR780
catalyze
endogenous
glucose,
leading
significantly
suppressed
glycolysis.
Moreover,
diIR780
released
selectively
accumulated
around
mitochondria
generate
toxic
ROS.
These
combined
effects,
turn,
hamper
metabolism
pathways,
which
are
crucial
for
driving
tumor
progression.
This
synchronous
intervention
strategy
enables
utter
devastation
providing
promising
regiment
eradicate
lesions
without
recurrence.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Abstract
The
second
near‐infrared
window
(NIR‐II)
fluorescence
imaging
has
been
widely
adopted
in
basic
scientific
research
and
preclinical
applications
due
to
its
exceptional
spatiotemporal
resolution
deep
tissue
penetration.
Among
the
various
fluorescent
agents,
organic
small‐molecule
fluorophores
are
considered
most
promising
candidates
for
clinical
translation,
owing
their
well‐defined
chemical
structures,
tunable
optical
properties,
excellent
biocompatibility.
However,
many
currently
available
NIR‐II
exhibit
an
“always‐on”
signal,
which
leads
background
noise
compromises
diagnostic
accuracy
during
disease
detection.
Developing
activatable
probes
(AOSFPs)
accurately
reporting
pathological
changes
is
key
advancing
toward
application.
This
review
summarizes
rational
design
strategies
AOSFPs
based
on
four
core
structures
(cyanine,
hemicyanine,
xanthene,
BODIPY).
These
hold
substantial
potential
translation.
Furthermore,
recent
advances
bioimaging
comprehensively
reviewed,
offering
clear
guidance
direction
further
development.
Finally,
prospective
efforts
advance
outlined.
ACS Central Science,
Journal Year:
2024,
Volume and Issue:
11(2), P. 208 - 218
Published: Dec. 21, 2024
Fluorescence
imaging
in
the
shortwave
infrared
(SWIR)
region
has
emerged
as
a
vital
tool
for
studying
mammals.
SWIR
emissive
polymethine
dyes
are
well-suited
to
this
endeavor;
however,
advancing
vivo
utility
with
these
is
primarily
limited
by
hydrophobicity
and/or
nonspecific
protein
association.
Herein,
we
take
distinct
approach
combine
hydrophilicity
and
stealth
behavior
construct
bright,
chromenylium
fluorophores
employing
well-defined
poly(2-methyl-2-oxazoline)
(POx)
star
polymer
architecture,
which
refer
stars,
or
"CStars."
Of
polymer-shielded
dyes,
variant
containing
five
POx
chains
(CStar30)
boasts
particularly
enhanced
aqueous
solubility
brightness,
enabling
high-resolution
mice.
The
swift
renal
clearance
displayed
also
achieves
improved
noninvasive
visualization
of
lymphatic
system.
Further,
CStar's
orthogonal
biodistribution
an
FDA-approved
dye,
indocyanine
green
(ICG),
facilitates
excitation-multiplexed
two
colors
achieve
simultaneous
both
fluid
dynamics
same
animal
real
time
at
video-rate
frame
counts.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(12), P. 1896 - 1904
Published: Feb. 22, 2024
Abstract
A
four-stage
method
for
the
synthesis
of
2H-imidazole-derived
push-pull
fluorophores
was
developed.
The
synthesized
compounds
are
characterized
by
absorption
in
range
250–400
nm,
emission
up
to
617
and
quantum
yields
99%.
Compounds
bearing
a
tetraphenylethylene
fragment
demonstrated
AIE
effect
solution
with
water
fraction
fw
>90%
significant
increase
intensity
20
times
22%.
ICT
states
these
were
confirmed
calculating
excited
state
dipole
moments
(>23D).
reported
synthetic
enables
fine-tuning
fluorescent
properties
developed
photoactive
molecular
systems
varying
donor
fragments.
obtained
could
be
particular
interest
design
organic
hybrid
materials.
