Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
Management
of
hard‐to‐heal
wounds
often
requires
specialized
care
that
surpasses
the
capabilities
conventional
treatments.
Even
most
advanced
commercial
products
lack
functionality
to
meet
needs
wounds,
especially
those
complicated
by
active
infection,
extreme
bleeding,
and
chronic
inflammation.
The
review
explores
how
supramolecular
nanovesicles
nanoparticles—such
as
dendrimers,
micelles,
polymersomes,
lipid‐based
nanocarriers—can
be
key
introducing
wound
healing
monitoring
properties
address
complex
wounds.
Their
potential
enable
functions
essential
for
next‐generation
products—such
hemostatic
functions,
transdermal
penetration,
macrophage
polarization,
targeted
delivery,
controlled
release
pharmaceutical
ingredients
(antibiotics,
gaseous
products,
anti‐inflammatory
drugs,
growth
factors)—is
discussed
via
an
extensive
overview
recent
reports.
These
studies
highlight
integration
systems
in
is
crucial
advancing
toward
a
new
generation
addressing
significant
gaps
current
management
practices.
Current
strategies
improvements
regarding
personalized
therapies,
promising
critically
evaluated
but
underexplored
polymer‐based
nanovesicles,
including
polymersomes
proteinosomes,
healing.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 1982 - 1982
Published: Feb. 6, 2024
The
skin
is
subject
to
damage
from
the
surrounding
environment.
repair
of
wounds
can
be
very
challenging
due
several
factors
such
as
severe
injuries,
concomitant
infections,
or
comorbidities
diabetes.
Different
drugs
and
wound
dressings
have
been
used
treat
wounds.
Tissue
engineering,
a
novel
therapeutic
approach,
revolutionized
treatment
regeneration
tissue
damage.
This
field
includes
use
synthetic
natural
biomaterials
that
support
growth
tissues
organs
outside
body.
Accordingly,
demand
for
polymer-based
strategies
defects
significantly
increasing.
Among
various
3D
scaffolds
in
hydrogel
gained
special
significance
their
unique
properties
mimicry
extracellular
matrix
(ECM),
moisture
retention,
porosity,
biocompatibility,
biodegradability,
biocompatibility
properties.
First,
this
article
delineates
process
healing
conventional
methods
treating
It
then
presents
an
examination
structure
manufacturing
hydrogels,
followed
by
analysis
crucial
characteristics
most
recent
advancements
using
purpose.
Finally,
it
discusses
potential
future
materials
within
realm
healing.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(24), P. 15681 - 15694
Published: June 7, 2024
The
prolonged
wound-healing
process
caused
by
pathogen
infection
remains
a
major
public
health
challenge.
developed
electrical
antibiotic
administration
typically
requires
metal
electrodes
wired
to
continuous
power
supply,
restricting
their
use
beyond
clinical
environments.
To
obviate
the
necessity
for
antibiotics
and
an
external
source,
we
have
wearable
synergistic
electroceutical
device
composed
of
air
self-charging
Zn
battery.
This
battery
integrates
sustained
tissue
regeneration
antibacterial
modalities
while
maintaining
more
than
half
initial
capacity
after
ten
cycles
chemical
charging.
In
vitro
bacterial/cell
coculture
with
demonstrates
inhibited
bacterial
activity
enhanced
cell
function
simulating
endogenous
electric
field
dynamically
engineering
microenvironment
released
chemicals.
provides
accelerated
healing
bacteria-infected
wound
stimulating
angiogenesis
modulating
inflammation,
effectively
inhibiting
growth
at
site.
Considering
simple
structure
easy
operation
long-term
treatment,
this
offers
great
potential
personalized
care.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(9), P. 2050 - 2050
Published: April 29, 2024
Deferoxamine,
an
iron
chelator
used
to
treat
diseases
caused
by
excess
iron,
has
had
a
Food
and
Drug
Administration-approved
status
for
many
years.
A
large
number
of
studies
have
confirmed
that
deferoxamine
can
reduce
inflammatory
response
promote
angiogenesis.
Blood
vessels
play
crucial
role
in
sustaining
vital
life
facilitating
the
delivery
immune
cells,
oxygen,
nutrients,
as
well
eliminating
waste
products
generated
during
cellular
metabolism.
Dysfunction
blood
may
contribute
significantly
development
life-threatening
diseases.
Anti-angiogenesis
therapy
pro-angiogenesis/angiogenesis
strategies
been
frequently
recommended
various
Herein,
we
describe
mechanism
which
promotes
angiogenesis
summarize
its
application
chronic
wounds,
bone
repair,
respiratory
system.
Furthermore,
discuss
drug
system
treating
diseases,
providing
constructive
ideas
inspiration
new
treatment
strategies.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 8, 2024
Intraoral
wounds
represent
a
particularly
challenging
category
of
mucosal
and
hard
tissue
injuries,
characterized
by
the
unique
structures,
complex
environment,
distinctive
healing
processes
within
oral
cavity.
They
have
common
occurrence
yet
frequently
inflict
significant
inconvenience
pain
on
patients,
causing
serious
decline
in
quality
life.
A
variety
novel
functional
dressings
specifically
designed
for
moist
dynamic
environment
been
developed
realized
accelerated
improved
wound
healing.
Thoroughly
analyzing
summarizing
these
materials
is
paramount
importance
enhancing
understanding
proficiently
managing
intraoral
wounds.
In
this
review,
particular
characteristics
are
firstly
described.
Up-to-date
knowledge
various
forms,
properties,
applications
existing
products
then
intensively
discussed,
which
categorized
into
animal
products,
plant
extracts,
natural
polymers,
synthetic
products.
To
conclude,
review
presents
comprehensive
framework
currently
available
dressings,
with
an
aim
to
provoke
inspiration
future
studies
design
more
convenient
versatile
materials.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(9), P. 910 - 910
Published: Sept. 23, 2024
Chronic
wounds
are
a
major
health
problem
because
of
delayed
healing,
causing
hardships
for
the
patient.
The
infection
present
in
these
plays
role
wound
healing.
Silver
dressings
have
been
used
decades,
beginning
1960s
with
silver
sulfadiazine
prevention
burn
wounds.
Since
that
time,
there
has
large
number
commercial
obtained
FDA
clearance.
In
this
review,
we
examine
literature
involving
vitro
and
vivo
(both
animal
human
clinical)
studies
attempt
to
glean
important
characteristics
treating
infected
primary
presentation
is
form
detailed
tables.
narrative
part
review
focuses
on
different
types
dressings,
including
supporting
matrix,
release
into
surroundings,
their
toxicity.
Though
many
clinical
chronic
using
discuss,
it
difficult
compare
performances
directly
differences
study
protocols.
We
conclude
can
assist
although
provide
general
treatment
guidelines.
From
dressing
point
view,
future
will
need
focus
new
delivery
systems
silver,
as
well
type
matrix
which
deposited.
Clearly,
adding
other
actives
enhance
antimicrobial
activity,
disruption
mature
biofilms
interest.
needs
be
healing
characteristics,
thus
randomized
control
trials
more
confidence
results.
application
specific
clarified,
along
It
most
likely
no
single
silver-based
all
