Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Intelligent
electronic
skin
aims
to
mimic,
enhance,
and
even
surpass
the
functions
of
biological
skin,
enabling
artificial
systems
sense
environmental
stimuli
interact
more
naturally
with
humans.
In
healthcare,
intelligent
is
revolutionizing
diagnostics
personalized
medicine
by
detecting
early
signs
diseases
programming
exogenous
for
timely
intervention
on‐demand
treatment.
This
review
discusses
latest
progress
in
bioinspired
its
application
healthcare.
First,
strategies
development
simulate
or
human
are
discussed,
focusing
on
basic
characteristics,
as
well
sensing
regulating
functions.
Then,
applications
health
monitoring
wearable
therapies
illustrating
potential
provide
warning
Finally,
significance
bridging
gap
between
emphasized
challenges
future
perspectives
summarized.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 686 - 686
Published: Feb. 4, 2025
Chronic
wounds
pose
a
substantial
healthcare
concern
due
to
their
prevalence
and
cost
burden.
This
paper
presents
detailed
overview
of
chronic
emphasizes
the
critical
need
for
novel
therapeutic
solutions.
The
pathophysiology
wound
healing
is
discussed,
including
stages
factors
contributing
chronicity.
focus
on
diverse
types
wounds,
such
as
diabetic
foot
necrosis,
pressure
ulcers,
venous
leg
highlighting
etiology,
consequences,
issues
they
provide.
Further,
modern
care
solutions,
particularly
hydrogels,
are
highlighted
tackling
challenges
management.
Hydrogels
characterized
multipurpose
materials
that
possess
vital
characteristics
like
capacity
retain
moisture,
biocompatibility,
incorporation
active
drugs.
Hydrogels’
effectiveness
in
applications
demonstrated
by
how
support
healing,
preserving
ideal
moisture
levels,
promoting
cellular
migration,
possessing
antibacterial
properties.
Thus,
this
hydrogel
technology’s
latest
developments,
emphasizing
drug-loaded
stimuli-responsive
underscoring
these
advanced
formulations
greatly
improve
therapy
outcomes
enabling
dynamic
focused
reactions
environment.
Future
directions
research
promote
development
customized
treatments
digital
health
tools
treatment
wounds.
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 1, 2025
Wound
healing
is
a
complex,
variable,
and
time-dynamic
repair
process.
Wounds
can
be
classified
as
acute
wounds
or
chronic
wounds,
effective
wound
management
still
major
challenge
in
clinical
nursing
settings.
The
microenvironment
collectively
regulated
by
internal
biomolecules,
external
drugs,
sanitation.
Traditional
dressings
(powders,
bandages,
sponges,
etc.)
often
have
poor
therapeutic
effects
during
processes
because
they
cannot
respond
to
the
dynamic
changes
over
long-term.
Stimulus-responsive
biomaterials,
which
are
activated
various
factors
intrinsic
influences,
hold
great
promise
for
precise
drug
delivery
controlled
release.
Various
stimulus-responsive
hydrogels
been
developed
recent
years,
exhibiting
range
of
“smart”
properties,
such
interacting
with
wound,
sensing
conditions
environmental
changes,
responding
accordingly,
thereby
effectively
promoting
healing.
This
review
discusses
latest
advancements
used
We
introduce
design
scheme
stimulus-response
detail
based
on
local
biological/biochemical
peculiarities
(pH,
reactive
oxygen
species
glucose,
enzymes,
physical
microenvironments
(temperature,
light,
ultrasound,
electric
fields,
etc.).
Furthermore,
we
explore
several
promising
tissue-engineered
constructs
(nanofibers,
scaffolds,
microneedles,
microspheres).
Finally,
summarize
basis
active
research
challenges,
current
progress,
development
trends
field.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
There
is
a
critical
unmet
need
to
improve
the
treatment
of
battlefield
burns.
Rapid
and
efficient
wound
protection
closure
are
essential
prevent
infections,
reduce
pain,
minimize
scarring.
This
study
introduces
portable,
field‐applicable
spray
system
designed
instantly
apply
protective
hydrogel
coating
with
therapeutic
agents
wounds
varying
sizes
shapes
for
emergency
treatments.
By
mimicking
natural
silk‐spinning
processes,
current
spray‐on
optimized
create
self‐standing,
spider‐web‐like
interwoven
structure
that
supports
tissue
adhesion,
cell
viability,
vascular
regeneration.
In
vivo
testing
in
porcine
burn
model
demonstrates
these
silk‐based
coatings,
especially
when
combined
antibiotics,
significantly
accelerated
healing
deep
partial‐thickness
burns
compared
standard
rapid
effective
performance
medical
use,
offering
an
advancement
functional
biomaterials.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Endogenous
electric
field
(EF)
originating
from
differences
in
ionic
gradients
plays
a
decisive
role
the
wound
healing
process.
Based
on
this
understanding,
self-manipulating
sodium
ion
gradient-based
endogenic
electrical
stimulation
dressing
(smig-EESD)
is
developed
to
achieve
passive,
non-invasive,
of
wounds,
which
avoids
side
effects
electrode
occupancy,
electrochemical
reactions,
and
thermal
present
traditional
exogenous
stimulation.
smig-EESD
reduced
potential
at
center
by
specifically
absorbing
Na+
exudate,
ultimately
strengthening
endogenous
EF.
Importantly,
converted
active
transport
dependent
Na+/K+-ATPase
into
passive
diffusion
adsorbing
extracellular
matrix
Na+,
saved
ATP
consumption
promoted
tissue
repair
regulated
innate
adaptive
immune
responses
upregulating
secretion
multiple
cytokines,
thereby
suppressing
injury-associated
inflammatory
reducing
scar
formation.
reveals
an
strategy
that
independent
electrodes
circuits,
provides
new
insights
future
development
electronic
medicine.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
Abstract
Diabetic
wounds
are
a
major
devastating
complication
of
diabetes
due
to
hyperglycemia,
bacterial
invasion,
and
persistent
inflammation,
the
current
antibiotic
treatments
can
lead
emergence
multidrug‐resistant
bacteria.
Herein,
bimetallic
nanozyme‐based
biomimetic
bio‐cocklebur
(GNR@CeO
2
@GNPs)
is
designed
synthesized
for
diabetic
wound
management
by
depositing
spiky
ceria
(CeO
)
shells
gold
nanoparticles
(GNPs)
on
nanorod
(GNR)
nanoantenna.
The
plasmonic‐enhanced
nanozyme
catalysis
self‐cascade
reaction
properties
simultaneously
boost
two‐step
enzyme‐mimicking
catalytic
activity
GNR@CeO
@GNPs,
leading
significant
improvement
in
overall
therapeutic
efficacy
rather
than
mere
additive
effects.
Under
glucose
activation
808
nm
laser
irradiation,
@GNPs
material
captures
photons
promotes
transfer
hot
electrons
from
GNR
GNPs
into
CeO
,
realizing
“butterfly
effect”
consuming
local
glucose,
overcoming
limited
antibacterial
efficiency
an
individual
PTT
modality,
providing
substantial
reactive
oxygen
species.
In
vitro
vivo
experiments
demonstrate
material's
exceptional
antibiofilm
against
Gram‐negative
Gram‐positive
bacteria,
which
reduce
promote
collagen
deposition,
facilitate
angiogenesis,
thereby
accelerating
healing.
This
study
provides
promising
new
strategy
develop
nanozymes
with
cascade
mode
antibiotic‐free
synergistic
treatment
infected
wounds.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Infected
wound
repair
stands
as
a
formidable
global
issue,
posing
significant
threats
to
public
health
and
medical
care.
Biopolymer‐based
dressings
represent
natural
biocompatible
candidate
greatly
conductive
healing.
However,
the
low
productivity
high
price,
coupled
with
widespread
lack
of
antibacterial
activities,
vitally
restrict
their
clinical
applications.
Herein,
simple
yet
efficient
top‐down
assembly
strategy
is
reported
fabricate
aggregation‐induced
emission
photosensitizer
(AIE‐PS)
functionalized
flexible
wood
(AIE/FW)
dressing
synergistic
photodynamic
therapy
moisture
management
accelerate
healing
infected
wounds.
On
account
its
superior
bactericidal
effectiveness
appropriate
management,
along
superb
flexibility
excellent
biocompatibility,
proposed
AIE/FW
can
effectively
prevent
infection
alleviate
inflammatory
response,
thereby
dramatically
boosting
recovery.
It
anticipated
that
scalable,
sustainable,
cost‐effective
offers
promising
pathway
overcome
care
challenges.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Precise
control
over
drug
release
rates
is
critical
for
enhancing
therapeutic
efficacy,
reducing
side
effects,
and
maintaining
stable
levels.
While
microneedles
(MNs)
offer
a
promising
approach
transdermal
delivery,
conventional
passive‐response
systems
often
lack
adaptability
across
diverse
drugs
disease
models,
limiting
their
versatility.
Here,
this
work
presents
flexible
bioelectronic
microneedle
patch
(FBMP)
that
integrates
electronics
actively
controlled
delivery.
The
FBMP
incorporates
printed
circuit
board
(FPCB),
eutectic
gallium‐indium
(EGaIn)
heating
film,
dual‐layer
with
polyvinyl
alcohol
(PVA)
core
polycaprolactone
(PCL)
shell.
This
configuration
allows
real‐time
adjustment
of
the
thermal
response
rate
via
smartphone‐controlled
Bluetooth,
achieving
rapid
within
2
min
or
sustained
10
h.
In
various
animal
demonstrate
versatility
in
delivering
multiple
types,
optimizing
minimizing
effects
both
acute
chronic
conditions.
Overall,
introduces
flexible,
universal
electronic
platform
significant
potential
to
advance
precision
personalized
medicine
by
enabling
customizable,
release.
