Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management DOI
Z. Zhuang, Yong Wang,

Zi‐Xuan Feng

et al.

Small, Journal Year: 2023, Volume and Issue: 20(18)

Published: Dec. 1, 2023

Abstract Wounds and the subsequent formation of scars constitute a unified complex phased process. Effective treatment is crucial; however, diverse therapeutic approaches for different wounds scars, as well varying needs at stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), novel minimally invasive transdermal drug delivery system, has potential integrated programmed various diseases shown promising applications types scars. In this comprehensive review, latest biotechnological innovations MNPs these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, manage related symptoms. Moreover, scenarios discussed. Additionally, side effects, manufacturing processes, material selection explore clinical translational investigated. This groundwork can provide theoretical basis serve catalyst future pursuit favorable options skin tissue regeneration.

Language: Английский

Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy DOI Creative Commons
Qinzhou Zheng,

Cuimin Chen,

Yong Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 965 - 992

Published: Jan. 1, 2024

Abstract: Diabetic wounds pose a significant challenge to public health, primarily due insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places physical burden on patients' prognosis, but also amplifies the economic strain medical system in treating diabetic wounds. Currently, effectiveness of available treatments for is limited. However, there hope potential metal nanoparticles (MNPs) address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial pro-angiogenic properties, making them promising solution In addition, stimulate expression proteins that promote wound healing serve as drug delivery systems small-molecule drugs. By combining with other biomaterials such hydrogels chitosan, novel dressings can be developed revolutionize treatment present article provides comprehensive overview research progress utilization Building upon this foundation, we summarize underlying mechanisms involved discuss application delivery. Furthermore, provide an extensive analysis discussion clinical implementation dressings, while highlighting future prospects utilizing management. conclusion, represent strategy healing. Future directions include biological nanomaterials synthesize new or physicochemical properties Synthetic contain play role all stages healing, stable physiological environment wound-healing process. Keywords: nanoparticles, wound, delivery, activity

Language: Английский

Citations

27
All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair DOI
Weikun Li, Zonghao Liu, Xin Tan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

Citations

23
Recent advances of hydrogels as smart dressings for diabetic wounds DOI
Xu Wang, Yuhan Yang, Weifeng Zhao

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

Citations

19
Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds DOI
Zhiyuan Hu,

Shan Jie,

Yuyu Cui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: May 25, 2024

Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.

Language: Английский

Citations

19
Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells DOI
Weinan Zhang,

Yechun Jiang,

Litao Liu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

Citations

3
Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management DOI Creative Commons
Kexin Yi, Yunru Yu, Lu Fan

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Language: Английский

Citations

15
Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives DOI

Zhaoyou Chu,

Wanni Wang,

Zheng Wang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8847 - 8877

Published: Jan. 1, 2024

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,

Language: Английский

Citations

13
It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms DOI Creative Commons
Yajuan Su,

Shatil S. M. Shahriar,

Syed Muntazir Andrabi

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(5)

Published: Jan. 13, 2024

Abstract Wound biofilms pose a great clinical challenge. Herein, this work reports dissolvable microneedle patch for dual delivery of monoclonal antibodies anti‐PBP2a and engineers antimicrobial peptides W379. In vitro antibacterial efficacy testing with patches containing combination 250 ng mL −1 W379 anti‐BPB2a decreases the bacterial count from ≈3.31 × 10 7 CFU to 1.28 2 within h without eliciting evident cytotoxicity. Ex vivo indicates co‐loaded displayed remarkable reduction load by ≈7.18 log after administered only once 48 h. The is significantly diminished compared treatment either or anti‐PBP2a‐loaded alone patches. When twice h, no bacteria are identified. Further in study also reveals that two treatments PVP colonies undetectable type II diabetic mouse wound biofilm model. Taken together, hold promise treating biofilms.

Language: Английский

Citations

9
Polydopamine-armored zeolitic imidazolate framework-8-incorporated zwitterionic hydrogel with multifunctional properties for infected wound healing DOI
Kangkang Wang,

Yaning Dong,

Donglin Gan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133464 - 133464

Published: June 28, 2024

Language: Английский

Citations

9
Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration DOI Creative Commons
Gloria Huerta‐Ángeles, Edgar Mixcoha

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 536 - 536

Published: Jan. 9, 2025

Hyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents key role several biological processes mammals. The synthesis/catabolism of critical pathologies has been used as marker for prognosis cancers. Among its physiological roles, wound healing applications. This review reports many latest developments hyaluronan derivatives research, preclinical, published clinical trials healing. An adequate physico-chemical characterization identification selected properties prepared material are mandatory. Moreover, cytotoxicity evaluation effects vitro using standardized protocols required preclinical. Finally, to choose vivo models testing efficacy requested. Unfortunately, still not well understood. Therefore, an overview HA-based products provided discussed. Several ways chemical modification were evaluated. this focuses on containing HA, novel developments, gaps, limitations current state art.

Language: Английский

Citations

1