Small,
Journal Year:
2023,
Volume and Issue:
20(18)
Published: Dec. 1, 2023
Abstract
Wounds
and
the
subsequent
formation
of
scars
constitute
a
unified
complex
phased
process.
Effective
treatment
is
crucial;
however,
diverse
therapeutic
approaches
for
different
wounds
scars,
as
well
varying
needs
at
stages,
present
significant
challenges
in
selecting
appropriate
interventions.
Microneedle
patch
(MNP),
novel
minimally
invasive
transdermal
drug
delivery
system,
has
potential
integrated
programmed
various
diseases
shown
promising
applications
types
scars.
In
this
comprehensive
review,
latest
biotechnological
innovations
MNPs
these
fields
are
thoroughly
explored,
summarizing
their
powerful
abilities
to
accelerate
healing,
inhibit
scar
formation,
manage
related
symptoms.
Moreover,
scenarios
discussed.
Additionally,
side
effects,
manufacturing
processes,
material
selection
explore
clinical
translational
investigated.
This
groundwork
can
provide
theoretical
basis
serve
catalyst
future
pursuit
favorable
options
skin
tissue
regeneration.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 11037 - 11052
Published: May 15, 2024
Diabetic
wound
infection
has
always
been
a
huge
threat
to
human's
healthcare,
and
most
of
the
existing
therapies
have
reduced
efficacy,
drug
resistance
toxic
side
effects.
Therefore,
there
is
an
urgent
need
develop
innovative
therapeutic
strategies
for
diabetic
management.
At
present,
intelligence
stimulus-responsive
bioactive
hydrogels
in
healing
received
extensive
attention.
This
mainly
reflected
on-demand
release
active
substances
response
physical,
chemical
or
biological
stimuli.
paper
focuses
on
potential
various
their
applications
healing,
briefly
discusses
factors
slow
preparation
methods
smart
hydrogels.
Finally,
future
development
further
management
wounds
presented.
Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Microneedles
(MNs)
have
emerged
as
a
promising
transdermal
antimicrobial
delivery
system,
providing
precise
and
localized
drug
while
complemented
with
noninvasiveness
patient
compliance.
Currently,
the
topical
application
of
antimicrobials
restricts
drugs
to
critical
areas
wound
bed,
largely
due
barriers
posed
by
necrotic
tissue,
scab
formation,
bacterial
biofilms,
which
severely
diminish
bioavailability
therapeutics.
MNs
enabled
efficient
targeted
overcome
many
chronic
challenges.
Over
past
decade,
significant
progress
has
been
made
develop
unique
properties
tailored
for
vaccines,
anticancer,
antimicrobials.
As
ongoing
research
continues
refine
MN
design,
material
properties,
formulations,
potential
revolutionizing
efficacy,
experience,
therapeutic
outcomes
remains
at
forefront
scientific
research.
In
this
review,
insights
are
provided
into
latest
progress,
current
developments,
diverse
applications
delivery.
Herein,
translational
is
highlighted
perspective
on
challenges
associated
clinical
translation
provided.
Furthermore,
review
aids
in
identifying
gaps
empowering
contributing
future
implementation
cutting‐edge
systems
effectively
tackle
resistance.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 8, 2024
In
diabetic
wounds,
hyperglycemia-induced
cytotoxicity
and
impaired
immune
microenvironment
plasticity
directly
hinder
the
wound
healing
process.
Regulation
of
hyperglycemic
remodeling
are
crucial.
Small,
Journal Year:
2023,
Volume and Issue:
20(18)
Published: Dec. 1, 2023
Abstract
Wounds
and
the
subsequent
formation
of
scars
constitute
a
unified
complex
phased
process.
Effective
treatment
is
crucial;
however,
diverse
therapeutic
approaches
for
different
wounds
scars,
as
well
varying
needs
at
stages,
present
significant
challenges
in
selecting
appropriate
interventions.
Microneedle
patch
(MNP),
novel
minimally
invasive
transdermal
drug
delivery
system,
has
potential
integrated
programmed
various
diseases
shown
promising
applications
types
scars.
In
this
comprehensive
review,
latest
biotechnological
innovations
MNPs
these
fields
are
thoroughly
explored,
summarizing
their
powerful
abilities
to
accelerate
healing,
inhibit
scar
formation,
manage
related
symptoms.
Moreover,
scenarios
discussed.
Additionally,
side
effects,
manufacturing
processes,
material
selection
explore
clinical
translational
investigated.
This
groundwork
can
provide
theoretical
basis
serve
catalyst
future
pursuit
favorable
options
skin
tissue
regeneration.
