Engineering Metal-Organic Framework Nanoparticles Trigger Pyroptosis to Boost Colon Cancer Immunotherapy DOI
Xiang Wang, Xufeng Lu, Xinxin Yang

et al.

Published: Jan. 1, 2023

Pyroptosis, which is a novel form of immunogenic cell death, plays vital role in antitumor therapy. Zirconium-based metal-organic frameworks (Zr-MOFs) have been applied various treatments. However, the intrinsic these pyroptosis remains to be determined. Here, Zr-MOF-based nanosystem (DOX@Zr-MOF) was constructed by loading Zr-MOF nanoparticles with chemotherapeutic drug doxorubicin (DOX) trigger cancer synergistically. We found that DOX@Zr-MOF rapidly triggered via activation canonical caspase-3/gasdermin E (GSDME)-dependent pathway, resulting significant suppression CT26 colon tumor growth vitro and vivo. Furthermore, significantly enhanced systemic immune response reprogramming immunosuppressive microenvironment. In addition, combination programmed death-1 (PD-1) immunotherapy highly improved efficacy for tumors. Collectively, this work will provide promising strategy pyroptosis-mediated anticancer treatment, may efficiently improve checkpoint blockade immunotherapy.

Language: Английский

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

Citations

52
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective DOI Creative Commons
Yifan Liu,

Renjie Pan,

Yuzhen Ouyang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

33
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

29
Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation DOI Creative Commons

Qianying Du,

Ying Luo,

Lian Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 6, 2024

Abstract Background The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, metastasis, current apoptosis-based fails to elicit sufficient immune response HCC. Results A smart responsive bimetallic nanovaccine was constructed induce immunogenic cell death (ICD) through pyroptosis enhance the efficacy of cGAS-STING pathway. composed manganese-doped mesoporous silica as a carrier, loaded with sorafenib (SOR) modified MIL-100 (Fe), where Fe 3+ , SOR, Mn 2+ were synchronized released into help microenvironment (TME). Afterward, worked synergistically SOR-induced (via both classical nonclassical signaling pathways), causing outflow abundant factors, which contributes dendritic (DC) maturation, exposure double-stranded DNA (dsDNA). Subsequently, exposed dsDNA jointly activated pathway induced release type I interferons, further led DC maturation. Moreover, -related T1 magnetic resonance imaging (MRI) used visually evaluate functionality nanovaccine. Conclusion utilization metallic nanovaccines pyroptosis-mediated activation provides promising paradigm HCC treatment.

Language: Английский

Citations

19
Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy DOI

Meng‐Jie Zhang,

Yuanyuan Wang,

Lin‐Lin Han

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

Citations

24
Magneto-optical nanosystems for tumor multimodal imaging and therapy in-vivo DOI Creative Commons
Mengzhen Wang, Yin Wang, Qinrui Fu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101027 - 101027

Published: March 16, 2024

Multimodal imaging, which combines the strengths of two or more imaging modalities to provide complementary anatomical and molecular information, has emerged as a robust technology for enhancing diagnostic sensitivity accuracy, well improving treatment monitoring. Moreover, application multimodal in guiding precision tumor can prevent under- over-treatment, thereby maximizing benefits patients. In recent years, several intriguing magneto-optical nanosystems with both magnetic optical properties have been developed, leading significant breakthroughs field image-guided therapy. These advancements pave way precise medicine. This review summarizes various types developed recently describes their applications probes agents therapeutic interventions. Finally, future research development prospects are discussed along an outlook on further biomedical field.

Language: Английский

Citations

10
Biodegradable Monometallic Aluminum as a Biotuner for Tumor Pyroptosis DOI

Yuan Liang,

Pengpeng Lei, Ran An

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Feb. 1, 2024

Pyroptosis is an effective anti-tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable Al can act as a biotuner tumor therapy. pH-sensitive nanoparticles (Al@P) are obtained by equipping polyethylene glycol-b-(poly(methyl methacrylate)-co-poly(4-vinylpyridine), which exert their effect at site without affecting normal cells. The H

Language: Английский

Citations

8
Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine DOI Creative Commons

Siqi Yu,

Yumo Zhang,

Zhuoran Zhou

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Pyroptosis, a form of programmed cell death characterized by lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel intelligent therapeutic strategies cancer, infectious diseases, chronic inflammatory conditions targeted activation reduced systemic toxicity. This review explores the mechanisms which NMs regulate comparing molecular NM inducers, examines role intrinsic properties such as size, shape, surface charge, chemical composition in these processes. It also discusses balance between beneficial adverse effects NM‐induced highlighting delivery systems, modifications, controlled to enhance efficacy intelligence while minimizing Notably, mRNA‐based nanomedicine be intelligently designed activate achieving desired outcomes tailored evolving microenvironment diseases. By understanding interactions, potential harnessed develop innovative treatments manage pyroptosis‐associated diseases safely, effectively, intelligently. highlights transformative clinical applications.

Language: Английский

Citations

0
Hyaluronic acid-modified doxorubicin-covalent organic framework nanoparticles triggered pyroptosis in combinations with immune checkpoint blockade for the treatment of breast cancer DOI

Shengsheng Zhao,

Binglong Bai,

Bingzi Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143265 - 143265

Published: April 1, 2025

Language: Английский

Citations

0
Engineering metal-organic framework nanoparticles trigger pyroptosis to boost colon cancer immunotherapy DOI Creative Commons
Xiang Wang, Xufeng Lu, Xinxin Yang

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 238, P. 112731 - 112731

Published: Feb. 1, 2024

Pyroptosis, which is a novel form of immunogenic cell death, plays vital role in antitumor therapy. Zirconium-based metal–organic frameworks (Zr-MOFs) have been applied various treatments. However, the intrinsic these pyroptosis has yet to be determined. Here, Zr-MOF-based nanosystem (DOX@Zr-MOF) was constructed by loading Zr-MOF nanoparticles with chemotherapeutic drug doxorubicin (DOX) synergistically trigger cancer pyroptosis. We found that DOX@Zr-MOF rapidly triggered via activation canonical caspase-3/gasdermin E (GSDME)-dependent pathway, resulting significant suppression CT26 colon tumor growth vitro and vivo. Furthermore, significantly enhanced systemic immune response reprogramming immunosuppressive microenvironment. In addition, combination programmed death-1 (PD-1) immunotherapy strongly improved efficacy tumors. Overall, this work provides promising strategy for pyroptosis-mediated anticancer treatment, may efficiently improve checkpoint blockade-related immunotherapy.

Language: Английский

Citations

3