Tissue Engineering Part A, Journal Year: 2025, Volume and Issue: unknown, P. e151 - e300
Published: May 7, 2025
Trends in biotechnology, Journal Year: 2023, Volume and Issue: 42(3), P. 339 - 352
Published: Oct. 16, 2023
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132878 - 132878
Published: June 5, 2024
Granular hydrogels have emerged as a new class of materials for 3D printing, tissue engineering, and food applications due to their extrudability, porosity, modularity. This work introduces convenient method prepare granular hydrogel with tunable properties by modulating the interaction between gum Arabic (GA) whey protein isolate (WPI) microgels. As concentration GA increased, appearance changed from fluid liquid moldable solid, microstructure macro-porous structure thin walls dense formed accumulation spherical particles. At 0.5 %, remained fluid. containing 1.0 % showed mechanical similar those tofu (compressive strength: 10.8 ± kPa, Young's modulus: 16.7 0.4 kPa), while 1.5 hawthorn sticks sausages 300.4 5.8 kPa; 200.5 3.4 kPa). The 2.0 was sticks, satisfactory bite resistance elasticity. Such tunability has led various application potentials in industry meet consumer demand healthy, nutritious, diverse textures.
Language: Английский
Citations
5
International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20
Published: April 10, 2024
Drug delivery via hydrogel is one of the most effective methods. Hydrogels have been described as polymeric water-swollen materials and retain water in distinctive three-dimensional complex. These are classified pH sensitive hydrogels, temperature homo-polymer co-polymer hydrogels Interpenetrating Network (IP-N) hydrogel. can be prepared various techniques, including physical crosslinking, chemical free radical polymerization, photo-initiator's hydrogen bonding. Various polymers manufacturing includes pectin, chitosan, cyclodextrin carrageenan, etc. This review aims to describes for drug delivery, classifications, preparation highlights novel applications medicine.
Language: Английский
Citations
4
Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(3), P. 240 - 261
Published: May 1, 2024
Language: Английский
Citations
4
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)
Published: June 12, 2024
Abstract Advancing the integration of nonliving and living components relies heavily on functional hydrogel materials with biocompatibility customizability. In this study, an enzyme‐assisted surface activation method is developed to produce reactive microparticles (HMPs) comprising thiolated hyaluronic acid hyperbranched poly(β‐hydrazide esters). Fluorescence labeling analysis reveals over six‐fold increase in surface‐active group density hydrogels three‐fold HMPs after enzyme activation. This enhancement improves accessibility active elements, facilitating post‐functionalization optimizing their capacity support initial cell adhesion spreading as carriers for cultures. Additionally, by utilizing exposed double bonds HMP surfaces post‐enzymatic treatment, are produced through a thiol‐ene coupling reaction polymers. These bond together spontaneously, resulting formation annealed granular interconnected large‐pore networks tunable storage modulus (G’) from tens hundreds pascals, compatible most soft tissues. Integrated 3D bioprinting, ink generates prints that foster adhesion, migration, growth, network formation. Moving forward, integrating various scaffold systems technique holds significant promise enhancing performance expanding applications regenerative medicine innovative materials.
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical biochemical in cells. However, the influence of biomimetic "rejuvenation" ECM structures on aging- degeneration-related cellular activities tissue repair is not well understood. We combined physical extrusion precise "on–off" alternating cross-linking methods to create anisotropic biomaterial microgels (MicroRod MicroSphere) explored how they regulate cell nucleus pulposus (NP) their potential antidegenerative effects intervertebral discs. NP cells exhibited aligned growth along surface MicroRod, enhanced proliferation, reduced apoptosis. This suggests an adaptive response involving adhesion mechanosensing, which causes cytoskeletal extension via environmental cues. maintain nuclear membrane integrity through YAP/TAZ pathway, activates cGAS-STING pathway rectify aging mechanisms. In vivo, MicroRod carries reduces inflammatory factor protease secretion degenerated discs, inhibiting degeneration promoting regeneration. Our findings highlight role stress maintaining activity antiaging harsh environments, providing a foundation for further research development biomaterials.
Language: Английский
Citations
0
Desalination, Journal Year: 2025, Volume and Issue: unknown, P. 118639 - 118639
Published: Feb. 1, 2025
Citations
0
Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Abstract 3D printing is a leading technique for fabricating tissue engineering scaffolds that facilitate native cellular behavior. Engineering to possess functional properties like electronic conductivity the first step toward integrating new technological capabilities stimulating or monitoring activity beyond traditionally presented biophysical and biochemical cues. However, these bioelectronic have been largely underdeveloped since majority of electrically conducting materials high stiffness values outside physiological range may negatively impact desired cell Here, methods poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogel techniques achieve relevant many soft tissues (<100 kPa) are reported. Structures confirmed as ideal by maintaining biostability, promoting viability, well appropriate morphology proliferation. These findings present customizable platform provides favorable microenvironments this envisioned be adaptable several applications.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
While granular hydrogels are increasingly used in biomedical applications, methods to capture their rheological behavior generally consider shear-thinning and self-healing properties or produce ensemble metrics such as the dynamic moduli. Analytical approaches paired with common oscillatory shear tests can describe not only solid-like fluid-like of but also transient characteristics inherent yielding unyielding processes. Combining testing consideration Brittility (Bt) via Kamani-Donley-Rogers (KDR) model, we show behave brittle yield stress fluids complex rheology. We quantify steady rheology a function microgel (composition; diameter) (packing; droplet heterogeneity) assembly for mixtures polyethylene glycol gelatin microgels. The KDR model Bt captures hydrogel wide range design parameters, reducing determination parameters. impact composition on parameters monolithic mixed hydrogels. robustly reveals relaxation time depends strain amplitude. This quantitative framework is an important step toward rational applications ranging from injection situ stabilization 3D bioprinting.
Language: Английский
Citations
0
Materials Today, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0