Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Bone
defects
resulting
from
trauma,
tumors,
or
other
injuries
significantly
impact
human
health
and
quality
of
life.
However,
current
treatments
for
bone
are
constrained
by
donor
shortages
immune
rejection.
tissue
engineering
has
partially
alleviated
the
limitations
traditional
repair
methods.
The
development
smart
biomaterials
that
can
respond
to
external
stimuli
modulate
biofunctions
become
a
prominent
area
research.
Ultrasound
technology
is
regarded
as
an
optimal
"remote
controller"
"trigger"
biomaterials.
This
review
reports
comprehensive
systematic
overview
ultrasound-responsive
It
presents
fundamental
theories
repair,
definition
ultrasound,
its
applications.
Furthermore,
summarizes
ultrasound
effect
mechanisms
their
roles
in
including
detailed
studies
on
anti-inflammation,
immunomodulation,
cell
therapy.
Finally,
advantages
future
prospects
this
field
discussed.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 129 - 143
Published: Jan. 1, 2025
At
present,
there
is
a
significant
population
of
individuals
experiencing
bone
deficiencies
caused
by
injuries,
ailments
affecting
the
bones,
congenital
abnormalities,
and
cancer.
The
management
substantial
defects
global
orthopedic
challenge
due
to
intricacies
involved
in
promoting
restoring
growth
fresh
osseous
tissue.
Autografts
are
widely
regarded
as
"gold
standard"
for
repairing
because
their
superior
tissue
acceptance
ability
control
osteogenesis.
However,
patients
undergoing
autografts
may
encounter
various
challenges,
including
but
not
limited
hernia,
bleeding,
nerve
impairment,
death.
Therefore,
researchers
regenerative
medicine
striving
find
alternatives.
Collagen
most
abundant
protein
human
body,
its
triple
helix
structure
gives
it
unique
characteristics
that
contribute
strength
functionality
tissues.
commonly
processed
into
forms
such
scaffolds,
sponges,
membranes,
hydrogels,
composite
materials,
compatibility
with
affinity
water,
minimal
potential
immune
reactions,
adaptability,
transport
nutrients
or
drugs.
As
an
alternative
material
field
regeneration,
collagen
becoming
increasingly
important.
objective
this
review
provide
comprehensive
analysis
primary
types
sources
collagen,
processes
synthesis
degradation,
well
advancements
made
regeneration
research
applications.
A
investigation
role
undertaken,
providing
valuable
points
reference
more
profound
comprehension
applications
field.
concluding
section
provides
overview
prospective
avenues
research,
underscoring
promising
future
highlighting
regeneration.
Translational
Potential
Article.
exploration
diverse
functions
translational
demonstrated
review,
these
findings
underscore
treatment
option
clinical
implications,
thus
paving
way
innovative
efficacious
therapeutic
strategies
domain.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1838 - 1838
Published: March 8, 2025
Bone
regeneration
has
emerged
as
a
critical
research
and
clinical
advancement
field,
fueled
by
the
growing
demand
for
effective
treatments
in
orthopedics
oncology.
Over
past
two
decades,
significant
progress
biomaterials
surgical
techniques
led
to
development
of
novel
solutions
treating
bone
defects,
surpassing
use
traditional
autologous
grafts.
This
review
aims
assess
latest
approaches
regeneration,
including
autologous,
allogenic,
xenogenic
grafts,
naturally
derived
biomaterials,
innovative
synthetic
substitutes
such
bioceramics,
bioactive
glasses,
metals,
polymers,
composite
materials,
other
specialized
applications.
A
comprehensive
literature
search
was
conducted
on
PubMed,
focusing
studies
published
between
2019
2024,
meta-analyses,
reviews,
systematic
reviews.
The
evaluated
range
strategies,
examining
outcomes,
materials
used,
techniques,
effectiveness
various
defects.
identified
numerous
studies,
with
inclusion
criteria
focused
those
exploring
strategies.
These
provided
valuable
insights
into
biological
outcomes
different
graft
types.
Results
indicated
that
while
advancements
show
promising
potential,
challenges
remain
optimizing
therapeutic
strategies
across
diverse
patient
populations
settings.
findings
emphasize
need
an
integrated
approach
combines
scientific
research,
practice,
technological
innovation
improve
therapies.
Further
is
required
establish
standardized
protocols
determine
optimal
application
enhance
quality
care.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 4, 2025
Osteoporosis
results
from
a
disruption
in
skeletal
homeostasis
caused
by
an
imbalance
between
bone
resorption
and
formation.
Conventional
treatments,
such
as
pharmaceutical
drugs
hormone
replacement
therapy,
often
yield
suboptimal
are
frequently
associated
with
side
effects.
Recently,
biomaterial-based
approaches
have
gained
attention
promising
alternatives
for
managing
osteoporosis.
This
review
summarizes
the
current
advancements
3D-printed
biomaterials
designed
osteoporosis
treatment.
The
benefits
of
compared
to
traditional
systemic
drug
therapies
discussed.
These
materials
can
be
broadly
categorized
based
on
their
functionalities,
including
promoting
osteogenesis,
reducing
inflammation,
exhibiting
antioxidant
properties,
inhibiting
osteoclast
activity.
3D
printing
has
advantages
speed,
precision,
personalization,
etc.
It
is
able
satisfy
requirements
irregular
geometry,
differentiated
composition,
multilayered
structure
articular
osteochondral
scaffolds
boundary
layer
structure.
limitations
existing
critically
analyzed
future
directions
considered.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(32), P. 21246 - 21257
Published: July 31, 2024
Biocompatible
batteries
can
power
implantable
electronic
devices
and
have
broad
applications
in
medicine.
However,
the
controlled
degradation
of
batteries,
impact
battery
catabolites
on
surrounding
tissues,
wireless
charging
designs
are
often
overlooked.
Here,
we
designed
an
zinc
ion
(ZIB)
using
a
gelatin/polycaprolactone-based
composite
gel
electrolyte.
The
prepared
ZIBs
deliver
high
specific
capacity
244.0
mA
h
g–1
(0.5C)
long
cycling
stability
300
cycles
(4C).
were
completely
degraded
within
8
weeks
rats
30
days
phosphate-buffered
saline
lipase
solution,
demonstrating
good
biocompatibility
degradability.
induced
macrophage
M2
polarization
exhibited
anti-inflammatory
properties,
with
mRNA
levels
markers
Arg-1
CD206
up-regulated
15.8-fold
13.4-fold,
respectively,
compared
to
blank
control
group.
Meanwhile,
expressions
two
typical
osteogenic
markers,
osteopontin
osteocalcin,
by
3.6-fold
5.6-fold,
that
promoted
differentiation
bone
marrow
mesenchymal
stem
cells.
Additionally,
energy
transmission
module
was
3D
printing
technology
realize
real-time
ZIB
rats.
is
promising
source
for
medical
also
serves
as
functional
material
accelerate
repair.
The International Journal of Advanced Manufacturing Technology,
Journal Year:
2024,
Volume and Issue:
134(3-4), P. 1043 - 1076
Published: Aug. 8, 2024
Abstract
This
paper
conceptualises
an
understanding
of
advanced
manufacturing
methods
to
develop
3D-printed
metallic
orthopaedic
implants,
including
a
brief
discussion
on
post-process
machining.
The
significance
Metallic
Additive
Manufacturing
(MAM)
and
its
practicality
for
industrial
applications
is
discussed
through
juxtaposition
with
conventional
casting
machining
approach.
Different
alloys
suitable
MAM
techniques
are
thoroughly
reviewed
determine
optimum
operating
conditions.
Although
can
produce
near-net
shape
parts,
post-processing
unavoidable
requirement
improve
surface
quality
dimensional
accuracy.
A
comparative
study
presented,
highlighting
the
importance
in
terms
cost
savings
performance.
materials
evaluated
aiming
overcome
problems
associated
existing
implants.
consequence
bone-implant
mechanical
mismatch
leading
stress
shielding
inadequate
corrosion
properties
obstructing
biodegradability
explored
detail.
effect
additive
parameters
mechanical,
corrosion,
biocompatibility
analysed.
Evidence
MAM’s
advantages
over
approaches,
such
as
use
functionally
graded
lattices
patient-specific
customised
designs,
also
presented.
Finally,
future
studies,
two-way
approach
conceptualised
material
selection
process
control
progressions
implant
development
using
MAM.
Graphical
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(39), P. 9863 - 9893
Published: Jan. 1, 2024
Schematic
diagram
of
the
device,
mechanism
and
biomedical
application
electrodeposition
for
preparation
bioactive
coatings
on
surface
titanium
implants
bone
repair.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 11, 2025
Bone
marrow
is
vital
for
hematopoiesis,
producing
blood
cells
essential
oxygen
transport,
immune
defense,
and
clotting.
However,
disorders
like
leukemia,
lymphoma,
aplastic
anemia,
myelodysplastic
syndromes
can
severely
disrupt
its
function,
leading
to
life-threatening
complications.
Traditional
treatments,
including
chemotherapy
stem
cell
transplants,
have
significantly
improved
patient
outcomes
but
are
often
associated
with
severe
side
effects
limitations,
necessitating
the
exploration
of
safer,
more
targeted
therapeutic
strategies.
Nanotechnology
has
emerged
as
a
promising
approach
addressing
these
challenges,
particularly
in
delivery
nutraceuticals—bioactive
compounds
derived
from
food
sources
potential
benefits.
Despite
their
promise,
nutraceuticals
face
clinical
limitations
due
poor
bioavailability,
instability,
inefficient
target
sites.
Nanoparticles
offer
viable
solution
by
enhancing
stability,
absorption,
transport
bone
while
minimizing
systemic
effects.
This
study
explores
range
disorders,
conventional
treatment
modalities,
nanoparticles
enhance
nutraceutical-based
therapies.
By
improving
efficacy,
could
revolutionize
disease
management,
providing
patients
effective
less
invasive
options.
These
advancements
represent
significant
step
toward
safer
efficient
approaches,
ultimately
prognosis
overall
health.
