Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Injectable
porous
microspheres
represent
a
promising
therapeutic
platform
for
cell
delivery,
drug
and
tissue
regeneration.
Yet,
the
engineering
of
silk
fibroin
with
highly
interconnected
structure
remains
an
unsolved
challenge.
In
this
study,
simple
efficient
method
is
developed
that
does
not
require
use
organic
solvents
to
prepare
predictable
structure.
Through
extensive
screening,
addition
glucose
found
direct
formation
from
interior
surface
microspheres.
Compared
(SF
microspheres)
produced
through
combination
electro‐spray,
cryopreservation,
freeze
drying,
fibroin‐glucose
(SF‐Glu
demonstrates
enhanced
capabilities
in
promoting
adhesion
proliferation
vitro.
Both
SF‐Glu
SF
exhibit
capacity
maintain
sustained
release
kinetics
loaded
model
drug.
Furthermore,
facilitate
recruitment
endogenous
cells,
capillary
migration,
macrophage
phenotype
switch
following
subcutaneous
injection
rats.
This
study
opens
new
avenue
construction
microspheres,
which
could
lead
broader
range
applications
regenerative
medicine.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Abstract
Imbalanced
mitochondrial
quality
control
is
strongly
linked
to
the
onset
and
development
of
osteoarthritis
(OA).
However,
current
research
primarily
focuses
on
local
cartilage
repair
phenotype
maintenance,
lacking
a
systematic
approach
subcellular
control.
To
address
this,
present
study
proposes
strategy
based
nanozyme
hydrogel
microspheres
(“mitochondrial
inspector”),
constructed
through
electrostatic
self‐assembly,
incorporation
dynamic
diselenide
bonds,
microfluidic
technology.
The
oxidative
stress
microenvironment
improved
by
cerium
dioxide
nanoparticles
combined
with
metformin
activate
autophagy
clear
persistently
dysfunctional
mitochondria,
thereby
inhibiting
OA
progression.
In
vitro
results
showed
that
“mitochondrial
inspector”
not
only
significantly
chondrocytes,
but
also
efficiently
scavenged
damaged
increased
membrane
potential
over
20‐fold,
notably
function
chondrocyte
homeostasis.
rat
model,
minimally
invasive
intra‐articular
injection
effectively
regulated
quality,
alleviated
matrix
degradation,
reduced
osteophyte
formation
≈80%,
Mankin
score
for
damage
70%.
summary,
this
presents
novel
microsphere‐based
treatment
OA,
providing
new
insights
therapies
other
aging‐related
diseases.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 3862 - 3882
Published: July 24, 2024
Osteoarthritis
(OA)
is
a
chronic
condition
characterized
by
degeneration
of
the
articular
cartilage
and
subsequent
bone
hyperplasia.
With
increasing
prevalence
driven
factors
such
as
aging
obesity,
OA
poses
growing
health
economic
burden.
Current
treatments,
including
NSAIDs
corticosteroid
injections,
offer
limited
efficacy
often
result
in
adverse
effects,
highlighting
urgent
need
for
novel
therapeutic
approaches.
Emerging
research
has
identified
hydrogel
microspheres
promising
solution
management.
These
microspheres,
with
their
tunable
physicochemical
properties
biocompatibility,
provide
conducive
environment
regeneration
sustained
drug
delivery.
Unlike
bulk
hydrogels,
enhanced
injectability,
uniform
distribution,
reduced
tissue
damage.
This
review
discusses
recent
advancements
microsphere
technology,
focusing
on
fabrication,
unique
mechanisms,
applications
OA.
Additionally,
we
address
challenges
future
directions
clinical
translation,
aim
to
optimize
treatment.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(12)
Published: Dec. 1, 2024
ABSTRACT
Recent
advancements
in
naturally
derived
bioadhesives
have
transformed
their
application
across
diverse
medical
fields,
including
tissue
engineering,
wound
management,
and
surgery.
This
review
focuses
on
the
innovative
development
multifunctional
nature
of
these
bioadhesives,
particularly
emphasizing
role
enhancing
adhesion
performance
wet
environments
optimizing
mechanical
properties
for
use
dynamic
tissues.
Key
areas
covered
include
chemical
physical
mechanisms
adhesion,
incorporation
multi‐adhesion
strategies
that
combine
covalent
non‐covalent
bonding,
bioinspired
designs
mimicking
natural
adhesives
such
as
those
barnacles
mussels.
Additionally,
discusses
emerging
applications
regeneration
musculoskeletal,
cardiac,
neural,
ocular
tissues,
highlighting
potential
bioadhesive‐based
therapies
complex
biological
settings.
Despite
substantial
progress,
challenges
scaling
lab‐based
innovations
clinical
overcoming
environmental
constraints
remain
critical.
Ongoing
research
bioadhesive
technologies
aims
to
bridge
gaps,
promising
significant
improvements
tailored
therapeutic
needs.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Topical
administration
of
CPI
NPs
alleviates
alkali
burn-induced
CRNV
in
rats,
accompanied
by
downregulation
FTO
expression
and
increased
RNA
m6A
modification,
with
reductions
IL-6,
TNF-α,
VEGF,
CD31
levels.
Created
Figdraw.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(29), P. 37683 - 37697
Published: July 9, 2024
Tissue
engineering
is
theoretically
considered
a
promising
approach
for
repairing
osteochondral
defects.
Nevertheless,
the
insufficient
osseous
support
and
integration
of
cartilage
layer
subchondral
bone
frequently
lead
to
failure
repair.
Drawing
from
this,
it
was
proposed
that
incorporating
glycine-modified
attapulgite
(GATP)
into
poly(1,8-octanediol-co-citrate)
(POC)
scaffolds
via
one-step
chemical
cross-linking
enhance
defect
repair
simultaneously.
The
effects
GATP
incorporation
ratio
on
physicochemical
properties,
chondrocyte
MC3T3-E1
behavior,
POC
scaffold
were
also
evaluated.
In
vitro
studies
indicated
POC/10%
improved
cell
proliferation
adhesion,
maintained
phenotype,
upregulated
chondrogenesis
osteogenesis
gene
expression.
Animal
suggested
has
significant
both
Therefore,
GATP-incorporated
system
with
dual-lineage
bioactivity
showed
potential
application
in
regeneration.
Journal of Microencapsulation,
Journal Year:
2024,
Volume and Issue:
41(6), P. 434 - 455
Published: July 5, 2024
Osteoarthritis
(OA),
affecting
around
240
million
people
globally
is
a
major
threat.
Currently,
available
drugs
only
treat
the
symptoms
of
OA;
they
cannot
reverse
disease's
progression.
The
delivery
to
afflicted
joints
challenging
because
poor
vasculature
articular
cartilage
results
in
their
less
bioavailability
and
quick
elimination
from
joints.
Recently
approved
such
as
KGN
IL-1
receptor
antagonists
also
encounter
challenges
inadequate
formulations.
Therefore,
microspheres
could
be
potential
player
for
intervention
OA
owing
its
excellent
physicochemical
properties.
This
review
primarily
focuses
on
distinct
biomaterials
acting
cargo
biologicals
via
different
routes
effective
management
OA.
Microspheres
can
improve
efficacy
therapeutics
by
targeting
strategies
at
specific
body
locations.
highlights
clinical
trials
conducted
last
few
decades.
