Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115477 - 115477
Published: Nov. 1, 2024
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
Sonophoresis is the most approachable mode of transdermal drug delivery system, wherein low‐frequency sonophoresis penetrates molecules into skin. It an alternative method for oral system and hypodermal injections. The cavitation effect thought to be main mechanism used in sonophoresis. process involves forming a gaseous bubble its rupture, induced coupled medium. Other mechanisms are thermal effects, convectional mechanical effects. mainly applies transporting hydrophilic drugs, macromolecules, gene delivery, vaccine delivery. also carrier‐mediated form micelles, liposomes, dendrimers. Some synergistic effects sonophoresis, along with some permeation enhancers, such as chemical iontophoresis, electroporation, microneedles, increased effectiveness penetration. Sonophoresis‐mediated ocular nail brain, sports medicine, sonothrombolysis widely used. In conclusion, while offers promising applications diverse fields, further research essential comprehensively elucidate biophysical governing ultrasound‐tissue interactions. Addressing these gaps understanding will enable refinement optimization sonophoresis‐based therapeutic strategies enhanced clinical efficacy.
Language: Английский
Citations
9
Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 89 - 89
Published: Jan. 23, 2025
Transdermal drug delivery minimizes pain and provides a controlled, stable release of drugs, but its effectiveness is limited by the skin’s natural barriers. Microneedles overcome this problem, enabling minimally invasive delivery. Microneedle patches (MNPs) with 80 µm-tall needles composed hyaluronic acid (HA) were developed evaluated for their formability, structural integrity, dissolution rate, skin penetration ability, transmission capacity. The influence molecular weight HA on these properties was also investigated. MNPs made from low-molecular-weight (30 kDa–50 kDa) demonstrated 12.5 times superior permeability in ex vivo human compared to needleless (NLPs). Furthermore, same test, had 1.7 higher than high-molecular-weight MNPs, suggesting transdermal administration. significantly influenced solubility permeability, highlighting potential as systems. Puncture tests depth 50–60 µm, indicating minimal nerve irritation dermis effective superficial dermal layer. These results present manufacturing technique incorporating model compounds highlight novel method biomedical applications soft gels.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(7)
Published: Nov. 27, 2023
Abstract Skin‐mediated drug delivery methods currently are receiving significant attention as a promising approach for the enhanced of drugs through skin. offers potential to overcome limitations traditional methods, including oral administration and intravenous injection. The challenges associated with permeation layers skin, which act major barrier, explored, strategies these discussed in detail. This review categorizes skin‐mediated based on means increasing permeation, it provides comprehensive overview mechanisms techniques methods. In addition, recent advancements application presented. also outlines ongoing research suggests future perspectives studies regarding drugs.
Language: Английский
Citations
18
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1403 - 1403
Published: Oct. 31, 2024
Several industries are increasingly focused on enhancing the delivery of active ingredients through skin to optimize therapeutic outcomes. By facilitating penetration barrier, these enhancers can significantly improve efficacy various formulations, ranging from skincare products agents targeting systemic circulation. As understanding physiology and mechanisms drug absorption deepen, adopting permeation more widely, ultimately leading better patient outcomes expanded treatment options. However, structure physiological function vary according different factors, such as area body between individuals. These variations, along with external environmental exposures, aging pathological conditions, introduce complexities that must be carefully considered when designing effective systems. Considering intricacies physiology, tailoring systems account for regional differences, individual variability, changes induced by factors or disease is critical optimizing This review discusses features structure, pathologies, well application in contexts. Furthermore, it addresses use animal models transdermal dermatological studies, latest developments this field.
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 56 - 56
Published: Jan. 6, 2025
The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially skin. In such conditions, supplementing exogenous antioxidants may help body prevent negative effect ROS. However, skin, as outermost barrier body, provides a perfect barricade, making delivery complicated. Several strategies have been developed enhance penetration through one is nanotechnology. This review focuses on utilizing several nanocarrier systems, including nanoemulsions, liposomes, solid lipid nanoparticles (SLNs), nanostructured carriers (NLCs), and polymeric nanoparticles, for transporting into We also reveal ROS formation skin role therapy, well natural sources antioxidants. Furthermore, we discuss clinical application topical therapy concomitantly current status using nanotechnology deliver will accelerate advancement therapy.
Language: Английский
Citations
0
Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease with growing prevalence worldwide. Topical corticosteroids and non‐steroidal calcineurin inhibitors (CNIs) are used as first‐line therapies for AD, but various side effects limit their long‐term use. Here, the first synthetic bilirubin(IIIα)‐derived nanoparticle reported, designated BRNP(IIIα), shows that it exhibits robust antioxidative immunomodulatory effectively reduces clinical symptoms of AD upon topical treatment. BRNP(IIIα) in 1% high molecular weight hyaluronic acid (BRNP(IIIα)/HA) readily infiltrates into dermis layer, notably downregulates disease‐associated reactive oxygen species (ROS) chemokines cytokines, suppresses recruitment leukocytes mast cells to AD‐induced lesions. BRNP(IIIα)/HA also significantly tissue‐resident memory T cell population, suggesting may inhibit recurrence. Furthermore, does not induce any adverse effect related irritation/sensitization or eye irritation human tissue. Collectively, findings suggest be useful an alternative CNIs safe, effective, treatment AD.
Language: Английский
Citations
0
Nano Trends, Journal Year: 2025, Volume and Issue: 9, P. 100085 - 100085
Published: Jan. 31, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106785 - 106785
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 107, P. 106788 - 106788
Published: March 5, 2025
Language: Английский
Citations
0