Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities DOI Creative Commons

Liucan Wang,

Guoqing Chen, Yang Yang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9889 - 9904

Published: Nov. 1, 2024

Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression inflammatory bowel disease (IBD) and presents potential therapeutic target. Anti-oxidant therapy, aimed at mitigating ROS, emerging as cornerstone IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise inhibiting inflammation through ROS scavenging, enhancing efficacy. Recent focus scavenging has centered on metal oxide nanoenzymes polyphenol-based nanomaterials. The primary challenges are catalytic efficiency functional integration these nanomaterials agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent unique catechol groups that interact biomolecules such proteins nucleic acids. strong ion chelating ability catechols enriches structure functionality nanomaterials, improving physicochemical nanocarriers enabling innovative designs multifunctional drug delivery systems (DDSs). Research DDSs expanded include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, polydopamine. These anti-oxidants, which incorporate polyphenols, demonstrated novel reduce essential components carriers. This review focuses design application for treatment, offering comprehensive discussion use polyphenols posed diverse roles strategies, including impact physical chemical DDSs.

Language: Английский

Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease DOI Creative Commons
Lin Cao,

Dengyi Duan,

Jing Peng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 13, 2024

Inflammatory bowel disease (IBD) is a progressive and debilitating inflammatory of the gastrointestinal tract (GIT). Despite recent advances, precise treatment noninvasive monitoring remain challenging.

Language: Английский

Citations

2
Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities DOI Creative Commons

Liucan Wang,

Guoqing Chen, Yang Yang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9889 - 9904

Published: Nov. 1, 2024

Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression inflammatory bowel disease (IBD) and presents potential therapeutic target. Anti-oxidant therapy, aimed at mitigating ROS, emerging as cornerstone IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise inhibiting inflammation through ROS scavenging, enhancing efficacy. Recent focus scavenging has centered on metal oxide nanoenzymes polyphenol-based nanomaterials. The primary challenges are catalytic efficiency functional integration these nanomaterials agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent unique catechol groups that interact biomolecules such proteins nucleic acids. strong ion chelating ability catechols enriches structure functionality nanomaterials, improving physicochemical nanocarriers enabling innovative designs multifunctional drug delivery systems (DDSs). Research DDSs expanded include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, polydopamine. These anti-oxidants, which incorporate polyphenols, demonstrated novel reduce essential components carriers. This review focuses design application for treatment, offering comprehensive discussion use polyphenols posed diverse roles strategies, including impact physical chemical DDSs.

Language: Английский

Citations

1