Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Overproduction of reactive oxygen species (ROS) during reperfusion in ischemic stroke (IS) severely impedes neuronal survival and results high rates morbidity disability. The effective blood‐brain barrier (BBB) penetration brain delivery antioxidative agents remain the biggest challenge treating reperfusion‐induced cerebrovascular neural injury. In this study, a metal‐organic framework (MOF) nanozyme (MIL‐101‐NH 2 (Fe/Cu)) with ROS scavenging activities to encapsulate neuroprotective agent rapamycin is fabricated decorating exterior BBB‐targeting protein ligands (transferrin), thereby realizing enhanced drug retention controlled release within lesions for synergistic treatment IS. Through receptor‐mediated transcellular pathway, transferrin‐coated MOF nanoparticles achieved efficient transport across BBB targeted accumulation at cerebral injury site mice middle artery occlusion/reperfusion (MCAO/R), wherein nanocarrier exhibited catalytic decomposition into O H ‐responsive release. By its BBB‐targeting, antioxidative, anti‐inflammatory, antiapoptotic properties, nanosystem addressed multiple pathological factors IS realized remarkable effects, leading substantial reduction infarction volume accelerated recovery nerve functions MCAO/R mouse model. This MOF‐based nanomedicine provides valuable design principles therapy multi‐mechanism synergies.

Language: Английский

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Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management

Drug Delivery, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 13, 2025

Silicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders cascade cellular oxidative stress via activation bioavailable silica, culminating in generation reactive oxygen species (ROS). Such mechanisms lead to irrevocable impairment. Contemporary scholarly examinations have underscored substantial antioxidative efficacy platinum nanoparticles (PtNPs), postulating their utility as an adjunct therapeutic modality silicosis management. The physicochemical interaction between PtNPs and demonstrates propensity for adsorption, thereby facilitating amelioration subsequent clearance aggregates. In addition detoxifying attributes, exhibit pronounced anti-inflammatory activities, which can neutralize ROS inhibit macrophage-mediated inflammatory processes. attributes are instrumental attenuating responses forestalling tissue damage. discourse delineates interplay PtNPs, pathogenesis its progression fibrosis, critically evaluates potential role landscape silicosis, alongside contemplation inherent limitations associated with application this context.

Language: Английский

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Enzyme-like CeO₂ Nanomaterials with Different Structure–Activity for Ulcerative Colitis Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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Core-shell hydrogel microspheres with sequential delivery of cerium oxide nanoparticles and spinal white matter extracellular matrix for improved functional recovery in spinal cord injury

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160861 - 160861

Published: Feb. 1, 2025

Language: Английский

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Dynamic regulation and targeted interventions of macrophages in ischemia–reperfusion injury

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Safflower Yellow Pigment Alleviates Cerebral Ischemia‐Reperfusion Injury via Protein Nitration and Oxidative Modulation

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)

Published: May 1, 2025

ABSTRACT Objective We seek to investigate the efficacy of safflower yellow pigment in mitigating cerebral ischemia‐reperfusion injury by examining its effects on protein nitration and oxidative modification. Methods A total 160 patients with acute ischemic stroke admitted department neurology Xingtai people's hospital were included this study. This study was a retrospective Patients divided into control group ( n = 80) observation according whether used. The received conventional treatment, pigment. Results Baseline characteristics did not significantly differ between two groups p > 0.05). Serum nitrosine levels lower compared after 24 h one week treatment < Similarly, serum carbonylated exhibited NIHSS modified rankin scale (mRS) scores, reduced area. Furthermore, malondialdehyde (MDA), C‐reactive (CRP), tumor necrosis factor‐alpha (TNF‐α) lower, while superoxide dismutase (SOD) activity higher Conclusion Safflower demonstrates significant neuroprotective reducing oxidation nitration, improving neurological function, area, attenuating stress inflammation.

Language: Английский

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Gene‐Engineered Cerium‐Exosomes Mediate Atherosclerosis Therapy Through Remodeling of the Inflammatory Microenvironment and DNA Damage Repair

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract The pro‐inflammatory immune microenvironment in the localized lesion areas and absence of DNA damage repair mechanisms endothelial cells serve as essential accelerating factors development atherosclerosis. lack targeted therapeutic strategies represents a significant limitation efficacy agents for In this study, Genetically engineered SNHG12‐loaded cerium‐macrophage exosomes (Ce‐Exo) are designed atherosclerosis‐targeting agents. vivo studies demonstrated that Ce‐Exo exhibited multivalent targeting properties macrophages, with 4.1‐fold higher atherosclerotic plaque‐aggregation ability than control drugs. This suggests has homing capacity deeper penetration into plaque. apolipoprotein E‐deficient mice, found to effectively remodel area, cell damage, inhibit study provides novel approach treatment atherosclerosis demonstrates potential cell‐derived drug carriers biomedicine.

Language: Английский

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Niobium Carbide Protects Myocardial Ischemia/Reperfusion Injury by Scavenging Reactive Oxygen Species and Improving Mitochondrial Function

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(14), P. 16283 - 16294

Published: July 15, 2024

Language: Английский

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Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring

Micromachines, Journal Year: 2024, Volume and Issue: 15(8), P. 1058 - 1058

Published: Aug. 22, 2024

Monitoring neural activity in the central nervous system often utilizes silicon-based microelectromechanical (MEMS) probes. Despite their effectiveness monitoring, these probes have a fragility issue, limiting application across various fields. This study introduces flexible printed circuit board (FPCB) characterized by robust mechanical and electrical properties. The demonstrate low impedance after platinum coating, making them suitable for multiunit recordings awake animals. capability allows simultaneous monitoring of large population neurons brain, including cluster data. Additionally, exhibit no fractures, failures, or issues during repeated-bending tests, both handling monitoring. possibility using this probe signal measurement animals, simply applying coating may encounter difficulties chronic tests other applications. Furthermore, suggests that FPCB can be advanced any method serve as an appropriate type tailorable systems

Language: Английский

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Toxicity Validation of Cerium Oxide Nanoparticles and Mechanism of Action in the Treatment of Cerebral Ischemia-Reperfusion Injury

Published: Jan. 1, 2024

Language: Английский

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