Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160665 - 160665
Published: Feb. 1, 2025
Language: Английский
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(4)
Published: March 21, 2024
Language: Английский
Citations
34
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract In this study, an electret‐inspired, charge‐injected hydrogel called QOSP (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar‐free healing of bacteria‐infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), polyaniline nanowires (PANI), forms a conductive network capable storing releasing electric charges, emulating electret‐like mechanism. This structure delivers signals continuously, enhancing wound by regulating responses minimizing fibrosis. mouse model second‐degree infected with Staphylococcus aureus (SA) Pseudomonas aeruginosa (PA), the accelerates 32% reduces bacterial load 60%, significantly inhibited scar formation 40% compared to controls. modulates Th1/Th2 balance toward Th1‐dominant antifibrotic state chitosan, thereby reducing collagen deposition 35%. Electro‐dielectric characterization reveals dielectric constant 6.2, 34% improvement in conductivity (3.33 × 10 −5 S/m) 30 °C increase thermal stability. Proteomic analysis highlights 50% down‐regulation pro‐inflammatory pro‐fibrotic pathways, suggesting controlled response conducive healing. study underscores potential bioelectrically active hydrogels as novel approach for treating wounds prone scarring.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141565 - 141565
Published: Feb. 27, 2025
Language: Английский
Citations
1
Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102380 - 102380
Published: April 10, 2024
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5249 - 5249
Published: May 11, 2024
In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal damage. Since most are designed internal use or treatments, the biodegradation is important. To endow with biodegradability, past few decades, various biodegradable polymers, either natural polymers (such chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, peptides) synthetic poly(lactic acid), polyurethanes, polycaprolactone, poly(lactic-co-glycolic acid)), been utilized develop novel adhesives. Incorporated degraded vivo time under specific conditions, leading destruction structure further degradation this review, we first summarize strategies utilizing Furthermore, provide a symmetric overview used adhesives, focus on degradability applications these Additionally, challenges perspectives polymer-based discussed. We expect that review can new inspirations design biomedical applications.
Language: Английский
Citations
7
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)
Published: July 23, 2024
Abstract Although bio‐adhesives have achieved many progresses, creating robust bio‐glues that could withstand the complex physiological microenvironment remains a significant challenge such as limited bioadhesion strength and stability, well slow adhesion speed caused by pH, enzymes, salt, bacteria. Herein, series of strong are successfully fabricated using polyphenol–acrylamide–ruthenium crosslinking (PARC) reaction under visible light irradiation, involving acrylamides radical polymerization, polyphenols (extracts) coupling reaction, ruthenium‐mediated photochemistry. The resulting underwent rapid sol–gel transition exhibited adhesive properties within short time (≈5 s), which quickly bond to various bio‐tissues. Moreover, these bioadhesives demonstrate high stability with mucosal tissue in oral environment, effectively promoting rat pig wound healing. It is anticipated this class light‐responsive polyphenolic serve tool for addressing defects clinic, offering promising alternative traditional treatments disorders.
Language: Английский
Citations
7
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(28), P. 6968 - 6980
Published: Jan. 1, 2024
Postoperative adhesions, a prevalent complication following abdominal surgery, affect 90% of patients undergoing surgical procedures. Currently, the primary approach to prevent postoperative adhesions involves physical isolation site and surrounding tissues using hydrogel; however, this method represents rudimentary strategy. Herein, considering impact oxidative stress free radicals on adhesion during wound healing, an injectable antioxidant hydrogel, named PU-OHA-D, was successfully synthesized, which is formed by crosslinking dopamine-modified oxidized hyaluronic acid (OHA-D) dihydrazide-terminated polyurethane (PU-ADH) through hydrazone bonding. PU-OHA-D hydrogel possesses versatile characteristics such as rapid gel formation, injectability, self-repair capability biodegradability. Additionally, they exhibit excellent ability clear superior tissue adhesion. can be injected
Language: Английский
Citations
4
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 82 - 97
Published: Aug. 23, 2024
Superficial cartilage defects represent the most prevalent type of injury encountered in clinical settings, posing significant treatment challenges. Here, we fabricated a extracellular matrix mimic hydrogel (GHC, consisting Gelatin, Hyaluronic acid, and Chondroitin sulfate) to avoid exacerbation deterioration, which is often driven by accumulation reactive oxygen species (ROS) pro-inflammatory microenvironment. The GHC exhibited multifunctional properties, including situ formation, tissue adhesiveness, anti-ROS capabilities, promotion chondrogenesis. enhancement adhesion was achieved chemically modifying hyaluronic acid chondroitin sulfate with o-nitrobenzene, enabling covalent connection surface upon light irradiation. In vitro characterization revealed that facilitated chondrocyte adhesion, migration, differentiation into cartilage. Additionally, hydrogels demonstrated ability scavenge ROS inhibit production inflammatory factors chondrocytes. animal model superficial injury, effectively promoted ECM regeneration interface integration between host material. These findings suggest hold considerable promise as strategy for defect repair. STATEMENT OF SIGNIFICANCE: clinic. Previous engineering materials are only suitable full-thickness or osteochondral defects. developed composed gelatin, sulfate, natural components. drug-free cell-free not avoids immune rejection drug toxicity, but also shows good mechanical properties biocompatibility. More importantly, could adhere tightly promote while protecting against oxidation. This ingredients potential material repairing
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160665 - 160665
Published: Feb. 1, 2025
Language: Английский
Citations
0