Polymer Applied in Hydrogel Wound Dressing for Wound Healing: Modification/Functionalization Method and Design Strategies

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Hydrogel wound dressings have emerged as a promising solution for healing due to their excellent mechanical and biochemical properties. Over recent years, there has been significant progress in expanding the variety of raw materials used hydrogel formulation along with development advanced modification techniques design approaches that enhance performance. However, comprehensive review encompassing diverse polymer strategies innovations is still lacking literature. This summarizes use natural polymers (e.g., chitosan, gelatin, sodium alginate, hyaluronic acid, dextran) synthetic poly(vinyl alcohol), polyethylene glycol, Pluronic F-127, poly(N-isopropylacrylamide), polyacrylamide, polypeptides) dressings. We further explore advantages limitations these discuss various strategies, including cationic modification, oxidative double-bond catechol etc. The also addresses principles synthesis methods, aligning modifications specific requirements healing. Finally, we future challenges opportunities hydrogel-based

Language: Английский

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Advances in the application of smart materials in the treatment of ophthalmic diseases

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123316 - 123316

Published: April 1, 2025

Language: Английский

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An injectable hydrogel with oxygen-generating and antioxidant properties for cardiac repair

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163699 - 163699

Published: May 1, 2025

Language: Английский

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Oxygen-Generating Hydrogels Combined with Electrical Stimulation: A Dual Approach for Promoting Diabetic Wound Healing

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 190, P. 95 - 106

Published: Nov. 1, 2024

Language: Английский

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Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 22, 2024

Abstract Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with immune response to damage being key determinant healing process's quality and duration. Post‐injury, crucial aspect is transition macrophages from pro‐inflammatory state an anti‐inflammatory. Thus, this alteration macrophage polarization presents enticing avenue within realm regenerative medicine. Recent advancements have entailed integration myriad cellular molecular signals into hydrogel‐based constructs, enabling fine‐tuning cell activities during different phases. This discussion explores modern insights roles skin regeneration, underscoring role modulation amplifying overall efficacy wounds. Moreover, comprehensive review presented on latest sophisticated technologies employed design immunomodulatory hydrogels regulate polarization. Furthermore, deliberate deliver targeted stimulation through manipulation chemistry also emphasized. overview provided regarding influence hydrogel properties traits process. Conclusively, accent forthcoming pathways directed toward modulating responses milieu healing.

Language: Английский

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Injectable Nanocomposite Hydrogel with Synergistic Biofilm Eradication and Enhanced Re-epithelialization for Accelerated Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Diabetic wounds remain a critical clinical challenge due to their harsh microenvironment, which impairs cellular function, hinders re-epithelialization and tissue remodeling, slows healing. Injectable nanocomposite hydrogel dressings offer promising strategy for diabetic wound repair. In this study, we developed an injectable dressing (HDL@W379) using LAP@W379 nanoparticles hyaluronic acid-based (HA-ADH-ODEX). This provided sustained, pH-responsive release of W379 antimicrobial peptides, effectively regulating the microenvironment enhance The HDL@W379 featured multifunctional properties, including mechanical stability, injectability, self-healing, biocompatibility, adhesion. vitro, achieved synergistic biofilm elimination subsequent activation basal cell migration endothelial tube formation. Pathway analysis indicated that enhances through MEK/ERK pathway activation. methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, accelerated healing by inhibiting bacterial proliferation promoting re-epithelialization, regenerating granulation tissue, enhancing collagen deposition, facilitating angiogenesis. Overall, continuously regulate offers innovative approach treating chronic wounds.

Language: Английский

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Injectable polyethylene glycol/methacrylated polylysine double cross-linked hydrogel releases neuropeptides for infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 284, P. 137972 - 137972

Published: Nov. 23, 2024

Language: Английский

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Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 213 - 228

Published: Dec. 16, 2024

Language: Английский

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