Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
Abstract
The
iron
oxide
nanoparticles
(IONs),
coated
with
different
materials,
are
synthesized
and
utilized
as
nucleating
agents
to
prepare
magnetic
multi‐modal
porous
scaffolds
of
poly
(lactic‐
co
‐glycolic
acid)/IONs
using
the
supercritical
carbon
dioxide
(ScCO
2
)
foaming
process.
effects
modification
including
citric
acid,
polycaprolactone,
polyvinyl
acetate,
on
process
properties
systematically
investigated.
results
indicate
that
solubility
diffusion
ability
CO
in
materials
played
a
vital
role
use
‐philic
high
pressure
proves
beneficial
generating
micropores.
structures
can
be
obtained
at
relatively
low
for
ScCO
systems
evaluated
this
study.
Furthermore,
prepared
exhibit
porosity
good
compressive
modulus
(higher
than
0.4
MPa),
satisfying
requirements
tissue
engineering
soft
scaffolds.
Gels,
Journal Year:
2024,
Volume and Issue:
10(8), P. 513 - 513
Published: Aug. 3, 2024
Nanoclay-composite
hydrogels
represent
a
promising
avenue
for
advancing
bone
tissue
engineering.
Traditional
face
challenges
in
providing
mechanical
strength,
biocompatibility,
and
bioactivity
necessary
successful
regeneration.
The
incorporation
of
nanoclay
into
hydrogel
matrices
offers
potential
unique
solution
to
these
challenges.
This
review
provides
comprehensive
overview
the
fabrication,
physico-chemical/biological
performance,
applications
nanoclay-composite
Various
fabrication
techniques,
including
situ
polymerization,
physical
blending,
3D
printing,
are
discussed.
In
vitro
vivo
studies
evaluating
biocompatibility
have
demonstrated
promoting
cell
adhesion,
proliferation,
differentiation.
Their
defect
repair,
osteochondral
engineering
drug
delivery
also
explored.
Despite
their
engineering,
such
as
optimal
dispersion,
scalability,
long-term
stability,
regulatory
approval,
integration
with
emerging
technologies
achieve
clinical
application.
Future
research
directions
need
focus
on
refining
enhancing
understanding
biological
interactions,
towards
translation
commercialization.
Overall,
offer
exciting
opportunities
improving
regeneration
strategies.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(2), P. 3852 - 3865
Published: Jan. 6, 2025
Polymer/ceramic
nanocomposites
integrated
the
advantages
of
both
polymers
and
ceramics
for
a
wide
range
biomedical
applications,
such
as
bone
tissue
repair.
Here,
we
reported
triphasic
poly(lactic-co-glycolic
acid)
(PLGA,
LA/GA
=
90:10)
with
improved
dispersion
hydroxyapatite
(HA)
magnesium
oxide
(MgO)
nanoparticles
using
process
that
benefits
ultrasonic
energy
dual
asymmetric
centrifugal
mixing.
We
characterized
microstructure
composition
evaluated
effects
HA/MgO
ratios
on
degradation
behavior
cell–material
interactions.
The
PLGA/HA/MgO
were
composed
70
wt
%
PLGA
30
made
20:10,
25:5,
29:1%
by
weight
HA
MgO,
respectively.
results
showed
had
homogeneous
nanoparticle
distribution
as-designed
elemental
composition.
cell
study
indicated
reducing
MgO
content
in
nanocomposite
increased
BMSC
adhesion
density
under
direct
indirect
contact
conditions.
Specifically,
after
24
48
h
culture,
group
ratio
70:29:1
(P70/H29/M1)
exhibited
greatest
average
conditions
among
nanocomposites.
During
28-day
study,
mass
loss
was
18
±
2%
P70/H20/M10,
9
P70/H25/M5,
7
1%
P70/H29/M1,
demonstrating
accelerated
Postculture
analysis
pH
values
Mg2+
ion
concentrations
media
increasing
Triphasic
provided
different
profiles
can
be
tuned
especially
when
shorter
or
longer
period
would
desirable
optimal
regeneration.
concentration
should
adjusted
optimized
other
modes
rates
are
used
Polymers,
Journal Year:
2025,
Volume and Issue:
17(7), P. 935 - 935
Published: March 29, 2025
Bone
tissue
engineering
aims
to
restore
lost
bone
and
create
an
environment
conducive
new
formation.
To
address
this
challenge,
we
developed
a
novel
biomimetic
hydrogel
that
combines
maleic
anhydride-modified
type
I
collagen
(ColME)
with
demineralized
decellularized
porcine
matrix
particles
(mDBMp),
forming
composite
ColME-mDBMp
(CMB)
hydrogel.
Chemical
modification
of
resulted
in
high
degree
substitution,
thereby
enhancing
its
photocrosslinkability.
Integration
mDBMp
into
the
ColME
via
photocrosslinking
enhanced
physiological
stability,
reduced
shrinkage,
improved
mechanical
strength
compared
gelatin
methacrylate
(GelMA)-based
hydrogels.
Moreover,
mineralization
CMB
promoted
formation
pure
hydroxyapatite
(HAp)
crystals,
providing
superior
stiffness
while
maintaining
ductility
relative
GelMA-based
In
vitro,
human
marrow
mesenchymal
stem
cells
(hBMSCs)
encapsulated
hydrogels
exhibited
proliferation,
cell-matrix
interactions,
osteogenic
differentiation,
as
evidenced
by
increased
calcium
deposition
histological
analysis.
These
results
demonstrate
hydrogel,
enriched
extracellular
(ECM)
components,
shows
considerable
promise
over
current
for
engineering.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4497 - 4509
Published: June 26, 2024
Although
visible
light-based
stereolithography
(SLA)
represents
an
affordable
technology
for
the
rapid
prototyping
of
3D
scaffolds
in
vitro
support
cells,
its
potential
could
be
limited
by
lack
functional
photocurable
biomaterials
that
can
SLA-structured
at
micrometric
resolution.
Even
if
innovative
photocomposites
showing
biomimetic,
bioactive,
or
biosensing
properties
have
been
engineered
loading
inorganic
particles
into
photopolymer
matrices,
main
examples
rely
on
UV-assisted
extrusion-based
low-resolution
processes.
Here,
SLA-printable
composites
were
obtained
mixing
a
polyethylene
glycol
diacrylate
(PEGDA)
hydrogel
with
multibranched
gold
nanoparticles
(NPs).
NPs
to
copolymerize
PEGDA
matrix
implementing
functionalization
protocol
involving
covalent
grafting
allylamine
molecules
C═C
pendant
moieties.
The
formulations
nanocomposites
tailored
achieve
high-resolution
fast
composite
via
SLA.
Furthermore,
it
was
demonstrated
that,
after
polymer
and
laser
structuring,
still
retained
their
unique
plasmonic
exploited
optical
detection
analytes
through
surface-enhanced
Raman
spectroscopy
(SERS).
As
proof
concept,
SERS-sensing
performances
printed
successfully
probe
molecule
(e.g.,
4-mercaptobenzoic
acid)
from
perspective
future
extensions
real-time
sensing
cell-specific
markers
released
within
cultures.
Finally,
biocompatibility
tests
preliminarily
embedded
also
played
key
role
inducing
physiological
cell-cytoskeleton
rearrangements,
further
confirming
potentialities
such
hybrid
as
groundbreaking
materials
laser-based
bioprinting.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Bioelectricity
plays
a
pivotal
role
in
human
physiology
and
pathology,
particularly
within
the
cardiovascular
system.
Myocardial
ischemia
disrupts
normal
transmission
of
electrical
signals
through
heart,
leading
to
cardiomyocyte
death,
ventricular
remodeling,
ultimately
heart
failure.
Electrical
stimulation
(ES)
has
been
proven
be
an
effective
strategy
for
treating
cardiac
diseases.
However,
invasive
electrode
implantation
unique
anatomical
position
limit
clinical
application
ES
therapy.
Developing
wireless
systems
that
effectively
enhance
bioelectric
propagation
activity
can
significantly
advance
therapeutic
interventions.
In
this
study,
lead‐free,
biodegradable
Food
Drug
Administration
approved
poly‐L‐lactic
acid
piezoelectric
nanofiber
is
designed
myocardium
under
ultrasonic
stimulation,
thus
promoting
structural
functional
recovery
tissue
murine
myocardial
infarction
model.
Further
study
shows
ultrasound‐driven
system
enhanced
mitochondria
function
angiogenesis
vivo
vitro
experiments.
Additionally,
regulate
intracellular
calcium
ion
concentration
cardia
contraction
rhythm
isolated
neonatal
rat.
Collectively,
findings
offer
novel
approach
treatment
diseases
potential
pacing
applications
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 31, 2024
The
complex
anatomy
and
biology
of
craniofacial
bones
pose
difficulties
in
their
effective
precise
reconstruction.
Injectable
hydrogels
(IHs)
with
water-swollen
networks
are
emerging
as
a
shape-adaptive
alternative
for
noninvasively
rebuilding
bones.
advent
versatile
nanomaterials
(NMs)
customizes
IHs
strengthened
mechanical
properties
therapeutically
favorable
performance,
presenting
excellent
contenders
over
traditional
substitutes.
Structurally,
NM-reinforced
energy
dissipative
covalently
crosslinked,
providing
the
mechanics
necessary
to
support
structures
physiological
functions.
Biofunctionally,
incorporating
unique
NMs
into
IH
expands
plethora
biological
activities,
including
immunomodulatory,
osteogenic,
angiogenic,
antibacterial
effects,
further
favoring
controllable
dynamic
tissue
regeneration.
Mechanistically,
NM-engineered
optimize
physical
traits
direct
cell
responses,
regulate
intracellular
signaling
pathways,
control
release
biomolecules,
collectively
bestowing
structure-induced
features
multifunctionality.
By
encompassing
state-of-the-art
advances
NM-integrated
IHs,
this
review
offers
foundation
future
clinical
translation
bone
Animals,
Journal Year:
2024,
Volume and Issue:
14(20), P. 2997 - 2997
Published: Oct. 17, 2024
Demineralized
bone
matrix
(DBM)
is
a
widely
used
allograft
material
for
repair,
but
its
handling
properties
and
retention
at
defect
sites
can
be
challenging.
Hydroxyethyl
cellulose
(HEC)
has
shown
promise
as
biocompatible
carrier
graft
materials.
This
study
aimed
to
evaluate
the
efficacy
of
DBM
combined
with
cancellous
putty
formed
using
HEC
an
regeneration
in
canine
tibial
model.
Experiments
were
conducted
dogs
proximal
defects.
Four
groups
compared:
empty
(control
group),
+
(DH),
(DCH),
calcium
phosphate
(DCCH).
Radiographic,
micro-computed
tomography
(CT),
histomorphometric
evaluations
performed
4
8
weeks
postoperatively
assess
regeneration.
The
Empty
group
consistently
exhibited
lowest
levels
throughout
period,
indicating
that
significantly
enhanced
At
week
4,
DCCH
showed
fastest
on
radiography
tomography.
By
8,
DCH
highest
area
ratio
new
among
all
experimental
areas,
followed
by
DH
groups.
demonstrated
enhances
handling,
mechanical
properties,
osteogenic
potential
grafts,
making
it
promising
clinical
applications
models.
When
mixed
bone,
which
high
porosity
strength,
becomes
offering
more
effective
reliable
option
repair
