Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157041 - 157041
Published: Oct. 1, 2024
Language: Английский
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 8, 2025
Language: Английский
Citations
8
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)
Published: March 12, 2025
Language: Английский
Citations
1
Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2568 - 2568
Published: Sept. 11, 2024
Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their transformative potential in realm transdermal administration. scrutiny centers on substrate materials pivotal for construction and core properties that dictate efficacy. We delve distinctive interplay between microneedles dermal layers, mechanisms by which this synergy enhances absorption precision targeting. Moreover, we examine acupoint-target organ-ganglion nexus, an innovative strategy steers concentration to specific targets, offering a paradigm medicine. A thorough analysis clinical applications systems is presented, highlighting adaptability impact across spectrum therapeutic domains. This also accentuates systems' promise bolster patient compliance, attributed minimally invasive painless mode delivery. present forward-looking strategies aimed at optimizing stimulation sites amplify benefits. The anticipation set introduction superior biocompatible with advanced mechanical properties, customizing cater specialized demands. In parallel, deliberate safety boosting loading capacities solidifying efficacy microneedle-based therapeutics. summation, role technology contemporary healthcare, charting course future investigative endeavors developmental strides within burgeoning field.
Language: Английский
Citations
5
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Detection of biomarkers associated with physiological conditions provides critical insights into healthcare and disease management. However, challenges in sampling analysis complicate the detection quantification protein within epidermal layer skin viscous liquid biopsy samples. Here, we present "Lab-on-the-Needles" concept, utilizing a microneedle patch-based sensing box (MNP-based SenBox) for mobile applications. This system facilitates rapid capture directly from situ or biopsies, followed by on-needle immediate assessment. The integration horseradish peroxidase-incorporated zeolitic imidazolate framework-8 (HRP@ZIF-8) as sensitive stable signal probe, limit anti-SARS-CoV-2 NP IgA antibodies various SARS-CoV-2 S1P mutant strains improves at least 1,000-fold compared to FDA-approved commercial saliva lateral flow immune tests. Additionally, MNP-based SenBox demonstrated minimally invasive monitoring inflammatory cytokine levels (TNF-α IL-1β) rats 30 min using portable ColorReader. study highlights potential collection layers biopsies that might facilitate diagnostics longitudinal monitoring.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106785 - 106785
Published: March 1, 2025
Language: Английский
Citations
0
BMEMat, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Abstract Recent strides in non‐invasive drug delivery have spurred innovation alternatives to traditional needle injections. Transdermal systems (TDDs) emerged as a particularly promising avenue, boasting minimal rejection rates, user‐friendly administration, and enhanced patient adherence. Beyond pharmaceuticals, TDDs show potential skincare cosmetics, leveraging their ability facilitate localized while minimizing systemic exposure. Nonetheless, the intricate physicochemical nature of skin presents formidable obstacles, prompting intensive exploration overcome these barriers. This comprehensive review delves into landscape methodologies, critically analyzing respective advantages, limitations, characterization prospective applications. advancements underscore robust efficacy TDDs, positioning it versatile indispensable modality poised for widespread integration across multifarious fields.
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Acupuncture, rooted in Traditional Chinese Medicine (TCM), serves as a complementary and alternative therapeutic modality that involves the insertion of needles into specific body points to stimulate treat variety conditions. Over time, acupuncture has garnered global acceptance, progressively addressing an increasing spectrum medical disorders. The integration nanotechnology holds considerable potential improve drug delivery efficacy broaden scope acupuncture's applications, providing novel opportunities for investigating underlying principles meridians acupoints. A bibliometric analysis application over past two decades (2004-2024) highlights emerging research trends focal field. This article provides overview history, biological mechanisms, preparation methods, clinical status nanoacupuncture, with focus on analyzing applications nanoacupuncture technology. Nanotechnology enables visualization imaging acupoints, facilitating deeper understanding physiological mechanisms behind effects. Modified incorporating can serve dual purposes: functioning sensors real-time monitoring various parameters, thereby supporting disease diagnosis enhancing through specialized interventions. Furthermore, nanotechnology-enhanced act platforms targeted working tandem responsive nanoparticles treatment. Despite its promising applicability, faces inherent limitations challenges must be addressed.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157041 - 157041
Published: Oct. 1, 2024
Language: Английский
Citations
2