Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)
Published: March 21, 2024
3D bioprinting possesses the potential to revolutionize contemporary methodologies for fabricating tissue models employed in pharmaceutical research and experimental investigations. This is enhanced by combining with advanced organs-on-a-chip (OOCs), which includes a complex arrangement of multiple cell types representing organ-specific cells, connective tissue, vasculature. However, both OOCs so far demand high degree manual intervention, thereby impeding efficiency inhibiting scalability meet technological requirements. Through combination drop-on-demand robotic handling microfluidic chips, print procedure achieved that proficient managing three distinct on chip within only minute, as well capable consecutively processing numerous without intervention. process rests upon development post-printing sealable chip, compatible different 3D-bioprinters easily connected perfusion system. The capabilities automized bioprint are showcased through creation multicellular vascularized liver carcinoma model chip. achieves full vascularization stable microvascular network formation over 14 days culture time, pronounced spheroidal growth albumin secretion HepG2 serving representative model.
Language: Английский
Citations
8Hydrogel-Based Vascularized Organ Tissue Engineering: A Systematized Review on Abdominal Organs
Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 653 - 653
Published: Oct. 12, 2024
Biomedical engineering, especially tissue is trying to provide an alternative solution generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim this study comprehensively review existing literature on hydrogel-based vascularized organ (i.e., liver, pancreas, kidneys, intestine, stomach spleen) engineering abdominal organs.
Language: Английский
Citations
4Biotechnological advances in 3D modeling of cancer initiation. Examples from pancreatic cancer research and beyond
Biofabrication, Journal Year: 2025, Volume and Issue: 17(2), P. 022008 - 022008
Published: Feb. 28, 2025
In recent years, biofabrication technologies have garnered significant attention within the scientific community for their potential to create advancedin vitrocancer models. While these been predominantly applied model advanced stages of cancer, there exists a pressing need develop pertinent, reproducible, and sensitive 3D models that mimic cancer initiation lesions native tissue microenvironment. Such hold profound relevance comprehending intricacies initiation, devise novel strategies early intervention, and/or conduct sophisticated toxicology assessments putative carcinogens. Here, we will explain pivotal factors must be faithfully recapitulated when constructing models, with specific focus on pancreatic lesions. By synthesizing current state research in this field, provide insights into advances breakthroughs. Additionally, delineate key technological biological challenges necessitate resolution future endeavors, thereby paving way more accurate insightfulin
Language: Английский
Citations
0Recent advances in blood-brain barrier-on-a-chip models
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0Artificial Human Blood Vessels for Tissue Engineering
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1626 - 1645
Published: March 27, 2025
Language: Английский
Citations
0The Future of Automated Tissue Engineering: Robotic‐Assisted Strategies for Complex 3D Tissue Bottom‐Up Assembly
Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown
Published: May 4, 2025
Abstract Over the years, need for novel solutions to replace damaged tissues has led development of new tissue‐engineering strategies. Bottom‐up approaches have gained interest mimicking hierarchical cellular organization and intricate nature tissues. Among these approaches, automated‐assisted techniques, such as robotic handling, potential precisely control spatial building blocks, allowing creation highly specific functional Recognizing handling in tissue engineering, this review provides an overview robot‐assisted bottom‐up engineering complex tissues, highlighting advantages limitations various systems currently being explored. To address growing field, also discusses key considerations assembly living while providing insights into future directions challenges rapidly evolving field.
Language: Английский
Citations
0Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386
Published: Sept. 26, 2024
Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.
Language: Английский
Citations
3Improving tumor microenvironment assessment in chip systems through next-generation technology integration
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Sept. 25, 2024
The tumor microenvironment (TME) comprises a diverse array of cells, both cancerous and non-cancerous, including stromal cells immune cells. Complex interactions among these play central role in driving cancer progression, impacting critical aspects such as initiation, growth, invasion, response to therapy, the development drug resistance. While targeting TME has emerged promising therapeutic strategy, there is need for innovative approaches that accurately replicate its complex cellular non-cellular interactions; goal being develop targeted, personalized therapies can effectively elicit anti-cancer responses patients. Microfluidic systems present notable advantages over conventional
Language: Английский
Citations
1Recent Advances in Blood Brain Barrier on Chip Models
Published: Jan. 1, 2024
Language: Английский
Citations
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