Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Abstract
The
origin
of
life
has
long
been
a
central
scientific
challenge,
with
various
hypotheses
proposed.
chemical
evolution,
which
supposes
that
inorganic
molecules
can
transform
into
organic
and
subsequent
primitive
cells,
laid
the
foundation
for
modern
theories.
Inorganic
minerals
are
believed
to
play
crucial
catalytic
roles
in
process.
However,
harsh
reaction
conditions
hinder
accumulation
molecules,
preventing
efficient
transition
from
biomacromolecules.
Given
inherent
physicochemical
properties
enzyme‐like
activities,
this
study
proposes
nanozymes,
nanomaterials
act
as
prebiotic
catalysts
life.
This
hypothesis
is
based
on
following:
First,
unlike
traditional
minerals,
nanominerals
catalyze
synthesis
under
milder
conditions.
Second,
not
only
protect
biomolecules
radiation
damage
but
also
polymerization
reactions
form
functional
biomacromolecules
further
lipid
vesicles.
More
importantly,
abundant
terrestrial
extraterrestrial
environments.
perspective
will
systematically
discuss
potential
nanozymes
emergence
functions
characteristics
nanozymes.
We
hope
research
bridge
gap
between
precursors
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 26, 2025
Nitric
oxide
(NO)
is
an
essential
molecule
in
biomedicine,
recognized
for
its
antibacterial
properties,
neuronal
modulation,
and
use
inhalation
therapies.
The
effectiveness
of
NO-based
treatments
relies
on
precise
control
NO
concentrations
tailored
to
specific
therapeutic
needs.
Electrochemical
generation
(E-NOgen)
via
nitrite
(NO2
-)
reduction
offers
a
scalable
efficient
route
controlled
production,
while
also
addressing
environmental
concerns
by
reducing
NO2
-
pollution
maintaining
nitrogen
cycle
balance.
Recent
developments
catalysts
E-NOgen
devices
have
propelled
conversion,
enabling
on-demand
production.
This
review
provides
overview
pathways,
with
focus
cutting-edge
Fe/Cu-based
catalysts,
explores
the
development
biomedical
use.
Challenges
future
directions
advancing
technologies
are
discussed.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 23, 2024
Photodynamic
therapy
and
ferroptosis
induction
have
risen
as
vanguard
oncological
interventions,
distinguished
by
their
precision
ability
to
target
vulnerabilities
in
cancer
cells.
therapy's
non-invasive
profile
selective
cytotoxicity
complement
ferroptosis'
unique
mode
of
action,
which
exploits
iron-dependent
lipid
peroxidation,
offering
a
pathway
overcome
chemoresistance
with
lower
systemic
impact.
The
synergism
between
photodynamic
is
underscored
the
depletion
glutathione
peroxidase
four
inhibitions
therapy-induced
reactive
oxygen
species,
amplifying
peroxidation
enhancing
ferroptotic
cell
death.
This
synergy
presents
an
opportunity
refine
treatment
modulating
redox
homeostasis.
Porphyrin-based
nanoscale
metal-organic
frameworks
hybrid
structures
exceptional
properties.
These
can
serve
platform
for
integrating
through
carefully
designed
functions.
nanostructures
be
engineered
deliver
multiple
therapeutic
modalities
simultaneously,
marking
pivotal
advance
multimodal
therapy.
review
synthesizes
recent
progress
porphyrin-modified
combined
ferroptosis,
delineating
mechanisms
that
underlie
synergistic
effects
context.
It
underscores
potential
porphyrin-based
advanced
nanocarriers
oncology,
propelling
field
toward
more
efficacious
tailored
treatments.
Advanced Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
