Gas Empowered Dual‐Cascade Strategy for Augmented Single‐Atom Nanotherapies DOI
Yong Liu,

Xiao‐Qiong Li,

Qiao Yu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Single‐atom nanotherapies have received numerous attention in malignant oncotherapy. However, the insufficient enzyme substrate and upregulation of heat shock proteins during therapeutic interventions are seldom concurrently noticed. Herein, a novel gas empowered dual‐cascade synergistic treatment strategy is demonstrated with domino effect, which can sequentially reinforce single‐atom nanozyme (SAzyme)‐based enzymatic therapeutics mild photothermal therapy (PTT) (< 45 °C). In proof‐of‐concept study, Fe single atom (Fe/SAzyme) loaded hydrogen sulfide (H 2 S) donor NaHS developed for HSPs‐silencing mediated PTT. The generated H S suppresses catalase activity to achieve “intracellular O conservation”, thereby furnishing Fe/SAzyme produce abundant cytotoxic hydroxyl radicals (·OH) augmented therapeutics. Then, excess ·OH induced mitochondrial dysfunction blocks adenosine triphosphate (ATP) energy supply realize cellular remodeling, hinders overexpression HSPs enhances PTT both vitro vivo. Consequently, gas‐triggered achieves S/·OH/mitochondrial endowing SAzymes maximum antitumor efficacy via combined This dual‐cascaded gas/enzymatic/mild oncotherapy not only exhibits new pathway gas‐facilitated PTT, but also offers valuable paradigm application “1 + 1 > 3” multimodal tumor therapy.

Language: Английский

NIR-triggered and Glucose-Powered Hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy DOI Creative Commons
Jingwei Wang, Yu Yin, Lingzhi Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101557 - 101557

Published: Feb. 5, 2025

Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.

Language: Английский

Citations

0
Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024) DOI
Siyang Cao,

Yingchen Pang,

Yihao Wei

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142798 - 142798

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy DOI Creative Commons

Jingchao He,

Guangtian Wang, Yongfang Zhou

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Language: Английский

Citations

0
Dual Nano-Reinforced 3D-Printed Polylactic Acid Scaffolds for Antibacterial and Osteogenic Applications DOI
Wang Guo,

Yuezhen Wei,

Bowen Li

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Facile Synthesis of Fe‐Based Metal‐Quinone Networks for Mutually Enhanced Mild Photothermal Therapy and Ferroptosis DOI

Zhendong Liu,

Sainan Liu,

Bin Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Mild photothermal therapy (MPTT) has emerged as a promising therapeutic modality for attenuating thermal damage to the normal tissues surrounding tumors, while heat-induced upregulation of heat shock proteins (HSPs) greatly compromises curative efficacy MPTT by increasing cellular thermo-tolerance. Ferroptosis been identified suppress overexpression HSPs accumulation lipid peroxides and reactive oxygen species (ROS), but is restricted overexpressed glutathione (GSH) in tumor microenvironment undesirable ROS generation efficiency. Herein, synergistic strategy based on mutual enhancement ferroptosis proposed cleaving recover cell sensitivity. A facile method fabricating series Fe-based metal-quinone networks (MQNs) coordinated assembly representative FTP MQNs possess high conversion efficiency (69.3 %). Upon 808 nm laser irradiation, not only trigger effective induce apoptosis more significantly, potentiate Fenton reaction marked GSH consumption boost ferroptosis, reinforced effect turn can alleviate resistance declining HSP70 defense reducing ATP levels. This study provides valuable rationale constructing large library achieving ferroptosis.

Language: Английский

Citations

3
Towards precision medicine: design considerations for nanozymes in tumor treatment DOI Creative Commons
Xinqiao Li,

Jinpeng Hu,

Q Zhao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 16, 2024

Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class catalysts, offering advantages such high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make highly suitable for large-scale production. In recent years, convergence nanomedicine nanocatalysis has highlighted potential diagnostic therapeutic applications, particularly tumor therapy. Despite these advancements, clinical translation remains hindered by lack designs tailored to specific characteristics, limiting their effectiveness targeted This review addresses mechanisms which induce cell death various types emphasizes key design considerations needed enhance potential. By identifying challenges opportunities field, this study aims provide foundation future nanozyme development, ultimately contributing more precise effective cancer treatments.

Language: Английский

Citations

3
Ferroptosis defense mechanisms: The future and hope for treating osteosarcoma DOI
Yulong Ma,

Liming Cong,

Wenxiang Shen

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)

Published: June 1, 2024

Currently, challenges such as chemotherapy resistance, resulting from preoperative and postoperative chemotherapy, recurrence, poor bone regeneration quality, are becoming increasingly prominent in osteosarcoma (OS) treatment. There is an urgent need to find more effective ways address these issues. Ferroptosis a novel form of iron-dependent programmed cell death, distinct other forms death. In this paper, we summarize how, through the three major defense systems ferroptosis, not only can substances traditional Chinese medicine, antitumor drugs, nano-drug carriers induce ferroptosis OS cells, but they also be combined with immunotherapy, differentiation therapy, treatment modalities significantly enhance sensitivity inhibit tumor growth. Thus, holds great potential treating OS, offering choices possibilities for future clinical interventions.

Language: Английский

Citations

2
Facile Synthesis of Fe‐Based Metal‐Quinone Networks for Mutually Enhanced Mild Photothermal Therapy and Ferroptosis DOI

Zhendong Liu,

Sainan Liu, Bin Liu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Mild photothermal therapy (MPTT) has emerged as a promising therapeutic modality for attenuating thermal damage to the normal tissues surrounding tumors, while heat‐induced upregulation of heat shock proteins (HSPs) greatly compromises curative efficacy MPTT by increasing cellular thermo‐tolerance. Ferroptosis been identified suppress overexpression HSPs accumulation lipid peroxides and reactive oxygen species (ROS), but is restricted overexpressed glutathione (GSH) in tumor microenvironment undesirable ROS generation efficiency. Herein, synergistic strategy based on mutual enhancement ferroptosis proposed cleaving recover cell sensitivity. A facile method fabricating series Fe‐based metal‐quinone networks (MQNs) coordinated assembly representative FTP MQNs possess high conversion efficiency (69.3 %). Upon 808 nm laser irradiation, not only trigger effective induce apoptosis more significantly, potentiate Fenton reaction marked GSH consumption boost ferroptosis, reinforced effect turn can alleviate resistance declining HSP70 defense reducing ATP levels. This study provides valuable rationale constructing large library achieving ferroptosis.

Language: Английский

Citations

0
Recent advances in chemotherapy for cancer therapy over Cu-based nanocatalysts DOI

Mengyu Wang,

Zhi‐Xin Li

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The recent progress of various Cu-based nanocatalysts in cancer therapy was reviewed, especially the remarkable achievements catalytic treatment tumor microenvironment through CDT and CDT-involved multimodal synergies.

Language: Английский

Citations

0
Gas Empowered Dual‐Cascade Strategy for Augmented Single‐Atom Nanotherapies DOI
Yong Liu,

Xiao‐Qiong Li,

Qiao Yu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Single‐atom nanotherapies have received numerous attention in malignant oncotherapy. However, the insufficient enzyme substrate and upregulation of heat shock proteins during therapeutic interventions are seldom concurrently noticed. Herein, a novel gas empowered dual‐cascade synergistic treatment strategy is demonstrated with domino effect, which can sequentially reinforce single‐atom nanozyme (SAzyme)‐based enzymatic therapeutics mild photothermal therapy (PTT) (< 45 °C). In proof‐of‐concept study, Fe single atom (Fe/SAzyme) loaded hydrogen sulfide (H 2 S) donor NaHS developed for HSPs‐silencing mediated PTT. The generated H S suppresses catalase activity to achieve “intracellular O conservation”, thereby furnishing Fe/SAzyme produce abundant cytotoxic hydroxyl radicals (·OH) augmented therapeutics. Then, excess ·OH induced mitochondrial dysfunction blocks adenosine triphosphate (ATP) energy supply realize cellular remodeling, hinders overexpression HSPs enhances PTT both vitro vivo. Consequently, gas‐triggered achieves S/·OH/mitochondrial endowing SAzymes maximum antitumor efficacy via combined This dual‐cascaded gas/enzymatic/mild oncotherapy not only exhibits new pathway gas‐facilitated PTT, but also offers valuable paradigm application “1 + 1 > 3” multimodal tumor therapy.

Language: Английский

Citations

0