Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism DOI Creative Commons
Yifan Su, Da-Jun Zheng,

Lingfeng Ge

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Photoacid generators (PAGs) and photohydride (PHGs) are specific photolabile protecting groups that release acid hydride, respectively. Over the past decade, great efforts have been devoted to developing novel PAGs PHGs with advanced efficiency, among which, two of promising candidates diarylethene (DAE)-based PHGs, which acids/hydrides during photochromic electrocyclization. The quantum yield for is acceptable, while only 4.2% even after molecular structure modification. In this work, time-resolved transient absorption spectroscopies femtosecond nanosecond resolutions along DFT/TD-DFT calculations were utilized unravel detailed photochemical reaction mechanisms DAE-based (1o) (2o), results show different key leads distinctive yields between 1o 2o. factors affecting discussed in detail, several design principles proposed facilitate future rational PHGs.

Language: Английский

Red/near-infrared light triggered photorelease via sensitized photolysis DOI
Donghao Lu,

Shu Yang,

Qiyu Yu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216117 - 216117

Published: July 27, 2024

Language: Английский

Citations

8
Seeing in the Future – a Perspective on Combining Light with Chemical Biology Approaches to Treat Retinal Pathologies DOI Open Access
Alexandre Specht,

Maxime Klimezak,

Sidney Cambridge

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

New concepts to treat eye diseases have emerged that elegantly combine unnatural light exposure with chemical biology approaches achieve superior cellular specificity and, as a result, improvement of visual function. Historically, without further molecular treatment has offered limited success including photocoagulation halt pathological blood vessel growth or low stimulate retinal cell viability. To add such treatments, researchers introduced various biological light-sensing molecules and combined those exposure. (Pre-)clinical trials describe the use optogenetics channelrhodpsins, i. e. light-sensitive ion channels, in patient vision restoration. In arena, pharmacological agents, rendered by reversible modification photosensitive protecting compounds ("caging"), been applied eyes living mice photo-release specific activities. Among these were successful proof-of-principle experiments conducted establish photo-sensitive gene therapies eye. For light-mediated combination biology, we wish here current frontiers research restoration an on differences between molecules, requirements, future outlooks.

Language: Английский

Citations

0
In Vivo Optogenetic Manipulation of Transgene Expression in Retinal Neurovasculature DOI Creative Commons

Eric Brandhorst,

Liang Xu,

Maxime Klimezak

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(8), P. 2818 - 2825

Published: July 15, 2024

The retina is prone to developing pathological neovascularization, a leading cause of blindness in humans. Because excess neovascularization does not affect the entire retina, global inhibition treatment angiogenesis critically interferes with healthy, unaffected retinal tissue. We therefore established an

Language: Английский

Citations

2
In vivo photopharmacological inhibition of hippocampal activity via multimodal probes – perspective and opening steps on experimental and computational challenges DOI Creative Commons
Johannes Gurke, Alejandro Carnicer‐Lombarte, Tobias E. Naegele

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(39), P. 9894 - 9904

Published: Jan. 1, 2024

A new perspective for the study/treatment of neurological conditions using in vivo photopharmacology is presented, including initial experimental and computational data.

Language: Английский

Citations

1
All-Visible-Light-Activated Diarylethene Photoswitches DOI Creative Commons
Ruiji Li, Ting Ou, Wen Li

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5202 - 5202

Published: Nov. 3, 2024

Photochromic compounds have attracted much attention for their potential applications in photo-actuators, optoelectronic devices and optical recording techniques. This interest is driven by key photochemical photophysical properties, which can be reversibly modulated light irradiation. Among them, diarylethene garnered extensive investigation due to excellent thermal stability of both open- closed-form isomers, robust fatigue resistance, high photocyclization quantum yield good photochromic performance solution solid phases. However, a notable limitation expanding the utility necessity ultraviolet induce photochromism. requirement poses challenges, as detrimental biological tissues, its penetration often restricted various media. review provides an overview design strategies employed development visible-light-responsive compounds. These serve guideline molecular design, with significantly broaden all-visible-light-activated realms materials science biomedical science.

Language: Английский

Citations

0
Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism DOI Creative Commons
Yifan Su, Da-Jun Zheng,

Lingfeng Ge

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Photoacid generators (PAGs) and photohydride (PHGs) are specific photolabile protecting groups that release acid hydride, respectively. Over the past decade, great efforts have been devoted to developing novel PAGs PHGs with advanced efficiency, among which, two of promising candidates diarylethene (DAE)-based PHGs, which acids/hydrides during photochromic electrocyclization. The quantum yield for is acceptable, while only 4.2% even after molecular structure modification. In this work, time-resolved transient absorption spectroscopies femtosecond nanosecond resolutions along DFT/TD-DFT calculations were utilized unravel detailed photochemical reaction mechanisms DAE-based (1o) (2o), results show different key leads distinctive yields between 1o 2o. factors affecting discussed in detail, several design principles proposed facilitate future rational PHGs.

Language: Английский

Citations

0