Inhibition of Malignant Pleural Effusion by a Physiological Intrapleural Pressure-controlled Piezo-catalytic Nanozyme System DOI
Hubing Shi, Zihan Xu, Yu Gui

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Malignant pleural effusion (MPE), persistently generated thorax tumor cells at advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered physiological intrapleural pressures during breath. Under the gently alterative pressure, nanoparticles produce burst of reactive oxygen species and induce immunogenic cell death catalysis carried ozone as well peroxide interstitial fluid. A clear biodistribution is observed tumors upon administration particle. Remarkably, due to abundant substrate oxygen-rich environment cavity, O3P@LPYU particle provides potently reduction MPE volume durable inhibition growth lung parenchyma. In conclusion, our work not only develops bio-responsive nano system, but also strategy persistent suppression clinics.

Language: Английский

New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

1
Harnessing Dual Phototherapy and Immune Activation for Cancer Treatment: The Development and Application of BODIPY@F127 Nanoparticles DOI Creative Commons
Yang Peng,

Chenyan Hu,

Ludan Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 28, 2024

Conventional phototherapeutic agents are typically used in either photodynamic therapy (PDT) or photothermal (PTT). However, efficacy is often hindered by hypoxia and elevated levels of heat shock proteins the tumor microenvironment (TME). To address these limitations, a formylated, near-infrared (NIR)-absorbing heavy-atom-free Aza-BODIPY dye presented that exhibits both type-I type-II PDT actions with high yield reactive oxygen species (ROS) manifests efficient conversion precise adjustments to conjugate structure electron distribution, leading large amount ROS production even under severe hypoxia. improve biosafety water solubility, an amphiphilic triblock copolymer (Pluronic F-127), yielding BDP-6@F127 nanoparticles (NPs) coated. Furthermore, inspired fact phototherapy triggers release tumor-associated antigens, strategy leverages potential immune activation combining PDT/PTT checkpoint blockade (ICB) amplify systemic response achieve much-desired abscopal effect developed. In conclusion, this study presents promising molecular design integrates multimodal therapeutics for effective approach cancer therapy.

Language: Английский

Citations

4
A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy DOI Creative Commons
Wen Meng, Ting Chen, Xueping Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

Citations

0
A multifunctional Pt/DMSN nanozyme-based colorimetric-fluorescence sensing platform for breast cancer detection DOI

Xinrui Xue,

Zheng Fang,

Yujia Luo

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)

Published: March 13, 2025

Language: Английский

Citations

0
A Single H2S-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention DOI
Ying Yin, Wentai Guo,

Q Y Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.

Language: Английский

Citations

0
Advancements in research on the precise eradication of cancer cells through nanophotocatalytic technology DOI Creative Commons

Changyang Yao,

Chen‐Song Zhang, Dongwei Fan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 1, 2025

The rapid development of nanotechnology has significantly advanced the application nanophotocatalysis in medical field, particularly for cancer therapy. Traditional treatments, such as chemotherapy and radiotherapy, often cause severe side effects, including damage to healthy tissues drug resistance. In contrast, nanophotocatalytic therapy offers a promising approach by utilizing nanomaterials that generate reactive oxygen species (ROS) under light activation, allowing precise tumor targeting minimizing collateral surrounding tissues. This review systematically explores latest advancements highly efficient nanophotocatalysts treatment, focusing on their toxicological profiles, underlying mechanisms cell eradication, potential clinical application. Recent research shows nanophotocatalysts, TiO2, In2O3, g-C3N4 composites, along with photocatalysts high conduction band or valence positions, ROS irradiation, which induces oxidative stress leads apoptosis necrosis. These cellular interacting key biological molecules DNA, proteins, lipids, triggering cascade biochemical reactions ultimately result death. Furthermore, strategies S-scheme heterojunctions vacancies (OVs) have been incorporated enhance charge separation efficiency absorption, resulting increased generation, improves photocatalytic performance targeting. Notably, these exhibit low toxicity cells, making them safe effective treatment modality. also discusses challenges associated therapy, limitations penetration need improved biocompatibility. findings suggest technology holds significant precision paving way safer more strategies.

Language: Английский

Citations

0
Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion DOI Creative Commons
Zihan Xu, Xiujing He, Yu Gui

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 3, 2025

Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered physiological intrapleural pressure during breath. Under gently alterative pressure, nanoparticles with notable peroxidase-like activity effectively produce burst of reactive oxygen species and induce immunogenic cell death catalysis carried ozone as well peroxide interstitial fluid. A clear sustained biodistribution is observed tumors upon administration particle. Remarkably, due to abundant substrates oxygen-rich environment cavity, O3P@LPYU particle provides potent reduction MPE volume durable inhibition growth thorax. Our work not only develops bio-responsive nano-system, but also strategy persistent suppression clinics.

Language: Английский

Citations

0
Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy DOI Creative Commons
Ying‐Chi Chen, Li-Chan Chang,

Yanling Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 5, 2025

Cancer remains a global health challenge necessitating innovative therapies. We introduce strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched c-type cytochromes. These, coupled Au NPs, facilitate autonomous transfer from cells, disrupting processes and inducing death. Effective across various types, larger NPs show enhanced efficacy, especially under hypoxic conditions. Oxidative stress Au@MIL (MIL: membrane-integrated liposome) treatments, including mitochondrial endoplasmic reticulum lipid oxidation potential changes, triggers apoptosis, bypassing iron-mediated pathways. Surface plasmon band X-ray absorption near-edge structure (XANES) analyses confirm transfer. A SiO2 insulator coating on blocks this transfer, suppressing damage. This approach highlights the of modulated pathways in targeted therapy, offering refined effective treatments.

Language: Английский

Citations

0
Two-Dimensional Materials in Bioelectronics DOI
Navid Rabiee

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 189, P. 118279 - 118279

Published: April 23, 2025

Language: Английский

Citations

0
Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism DOI Creative Commons
Yanan Wang, Qi Zhang,

Minrui Kan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 31, 2024

Au@Pt nanozyme, a bimetallic core–shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity stability. Here, we propose that improves glucose tolerance reduces TG after four weeks administration. The transcriptomic analysis of mouse liver tissues treated with nanozyme showed changes in genes related lipid metabolism signaling pathways, including glycolysis/gluconeogenesis, pyruvate metabolism, PPAR signaling, insulin signaling. Moreover, fecal samples from mice the abundance beneficial gut microbiota such as Dubosiella, Parvibacter, Enterorhabdus, Monoglobus, Lachnospiraceae_UCG-008, Lachnospiraceae_UCG-006, Lachnospiraceae_UCG-001, Christensenellaceae_R-7_group. Combined multi-omics correlation analyses revealed modulation by was strongly correlated hepatic gene expression profiles well microbial profiles. Overall, our integrated demonstrated could modulate regulating key altering composition microbiota, providing new insights into potential applications treatment metabolic disorder.

Language: Английский

Citations

2