Cited by Hyaluronic acid modified Cu/Mn-doped metal-organic framework nanocatalyst for chemodynamic therapy

Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications DOI

Yong Pan, Han Zhao, Wenyong Huang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

Citations

Phototherapy: progress, challenges, and opportunities DOI

Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

A proton pump inhibitor-programmed ROS generator enhances the synergistic efficacy of chemo-/chemodynamic therapy with reduced renal injury DOI

Jiaxuan Li, Yanqing Li, Yi Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159201 - 159201

Published: Jan. 1, 2025

Language: Английский

Citations

Glutathione depletion-based pH-responsive injectable hydrogels for synergistic treatment of colon tumor DOI

Xinyuan Zhang, Yu Li, Yanhui Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139557 - 139557

Published: Jan. 6, 2025

Language: Английский

Citations

Mixed-valence vanadium-doped mesoporous bioactive glass for treatment of tumor-associated bone defects DOI

Xin Liu, Pengfei Zhang,

Mengjie Xu

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Vanadium is a bioactive trace element with variable valence. Its pentavalent form has been confirmed to be capable of predominantly regulating the early and mid-stage osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) without tumor inhibition, while its tetravalent exhibits inhibition but only primarily modulates late angiogenesis. In this study, multifunctional tissue scaffold consisting mixed-valence vanadium-doped mesoporous glass poly(lactic-co-glycolic acid) (V(IV/V)-MBG/PLGA) was developed simultaneously inhibit recurrence osteosarcoma promote regeneration operative defects. The in vitro results showed that V(IV) V(V) species could sustainably released from V(IV/V)-MBG complementarily enhance proliferation, differentiation, mineralization BMSCs by activating multiple signaling pathways throughout whole osteogenesis process. More importantly, co-existence mixed-valent vanadium able continuously stimulate generation excessive ROS depletion GSH synergistically supplying an appropriate ratio thermodynamically kinetically maintain stable self-circulation valence state alteration, thus inducing UMR-106 cell death. rat model, V(IV/V)-MBG/PLGA scaffolds effectively suppressed invasion promoted regeneration. These suggest are promising strategy for treating tumor-associated defects, offering dual

Language: Английский

Citations

Injectable Magnetic-Nanozyme Based Thermosensitive Hydrogel for Multimodal DLBCL Therapy DOI

Min Yan,

Jingcui Peng,

Haoan Wu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 218 - 218

Published: March 20, 2025

Diffuse large B-cell lymphoma (DLBCL), accounting for 31% of non-Hodgkin lymphomas, remains recalcitrant to conventional therapies due chemoresistance, metastatic progression, and immunosuppressive microenvironments. We report a novel injectable Fe3O4@DMSA@Pt@PLGA-PEG-PLGA hydrogel system integrating magnetothermal therapy (MHT), chemodynamic (CDT), immunomodulation. Under alternating magnetic fields (AMF), the achieves rapid therapeutic hyperthermia (50 °C within 7 min) while activating pH/temperature-dual responsive peroxidase (POD) -like activity in Fe3O4@DMSA@Pt nanoparticles. Catalytic efficiency under tumor-mimetic conditions was significantly higher than Fe3O4@DMSA controls, generating elevated reactive oxygen species (ROS). Flow cytometry revealed 75.9% apoptotic cell death A20 cells at 50 °C, surpassing CDT alone (24.5%). Importantly, this dual mechanism induced immunogenic (ICD) characterized by 4.1-fold CRT externalization, 68% HMGB1 nuclear depletion, 40.74 nM ATP secretion. This triggered robust dendritic maturation (92% CD86+/CD80+ DCs comparable LPS controls) T activation (16.9% CD25+/CD69+ ratio, 130-fold baseline). Our findings validate potential magnetothermal-chemodynamic synergy DLBCL treatment, paving way innovative multi-mechanism strategies against with clinical translation prospects.

Language: Английский

Citations

Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives DOI

Jie Gou,

Lu Chen,

Tianyu Liu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102702 - 102702

Published: April 1, 2025

Language: Английский

Citations

Elongated Magnetic Nanorobots with Multi-Enzymatic Cascades for Active In Vivo Tumor Targeting and Enhanced Chemodynamic Therapy DOI

Diyan Li, Chi Zhang, Qirong Xiong

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Targeted delivery of therapeutic agents to malignant tissues is crucial for enhancing clinical outcomes and reducing side effects. Magnetic nanorobots (MNRs) present a promising strategy controlled delivery, leveraging external magnetic fields achieve precise in vivo targeting. This work develops elongated MNRs comprising linearly arranged nanoparticles linked by metal-polyphenol complexes (MPCs) magnetic-field-directed active tumor targeting synergistic therapy. The are created assembling 30 nm Fe3O4 nanoparticles, tannic acid, ferrous ions (Fe2+) under uniform field, resulting chain-like structures fixed MPCs, which also promotes peroxidase-like activity. These show greater response than individual offering flexibility manipulation. MPCs coating allows tailored surface modifications with glucose oxidase, copper (Cu2+), human serum albumin (HSA), producing colloidally stable built-in multienzymatic cascade (MNRs@GOx/Cu/HSA) that consumes glucose, generates •OH, depletes the antioxidant glutathione (GSH). Collectively, surface-engineered multifunctional demonstrate improved driven fields, leading efficient localized chemodynamic structural functional properties developed render them suitable targeted cargo minimally invasive surgery, treatments disease sites.

Language: Английский

Citations

Enhanced sequential osteosarcoma therapy using a 3D-Printed bioceramic scaffold combined with 2D nanosheets via NIR-II photothermal-chemodynamic synergy DOI

Guangyu Jian, Si Wang, Xinlu Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 540 - 555

Published: May 1, 2025

Language: Английский

Citations

Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations DOI

Jiaqing Zhang,

Xiang Cao,

Huiyun Wen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216746 - 216746

Published: May 2, 2025

Language: Английский

Citations