An anticoagulant supercapacitor for implantable applications

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 3, 2024

With the rapid advancement of implantable electronic medical devices, supercapacitors have emerged as popular energy storage devices. However, inevitably come into direct contact with blood when implanted, potentially causing adverse clinical reactions such coagulation and thrombosis, impairing performance implanted posing a serious threat to human health. Therefore, this work aims design an anticoagulant supercapacitor by heparin doped poly(3, 4-ethylenedioxythiophene) (PEDOT) for possible applications in bioelectronics. Heparin (Hep), as-known macromolecule acts counterion PEDOT doping enhance its conductivity, bioelectrode material PEDOT: Hep activity is synthesized via chemical oxidation polymerization. Concurrently, constructed through in-situ polymerization, where bacterial cellulose electrode electrolyte layer, respectively. Owing incorporation heparin, exhibits high hemocompatibility hemolysis rate <5 %, good time 63.4 s, reasonable cycle stability capacitance retention 76.24 % after 20, 000 cycles, supplies power heart sensors female mice. This provides platform electronics achieve vivo. Implantable are promising use supply devices within body, but their utility hindered thrombosis. Here, authors report that properties cycling stability.

Language: Английский

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Vitamin C Secondary‐Doped Poly(3, 4‐ethylenedioxythiophene): Poly(Styrene Sulfonate) for Enhancing Conductivity and Biocompatibility for Implantation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Poly(3, 4‐ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT: PSS) has garnered increasing attention due to its adjustable and enhanced electrical conductivity ease of processing. However, for applications in bioelectronics as a conductive filler the preparation hydrogels, further improvements are necessary. In this study, an eco‐friendly polar additive, vitamin C (VC), is introduced simultaneously enhance biocompatibility PEDOT: PSS. The multiple hydroxy groups VC impart polarity facilitate hydrogen bonding with PSS, thereby removing excess non‐conductive PSS not involved polymerization expanding continuously conducting PEDOT‐rich domains. Importantly, can regulate inflammatory factors by reducing reactive oxygen species levels, effectively improving biocompatibility. Consequently, secondary‐doped shows potential diverse properties, solubility, biocompatibility, blood compatibility. A hydrogel prepared incorporating PSS‐VC into sodium alginate guar gum system. Supercapacitors anticoagulant properties assembled address thrombosis, coagulation risks, responses vivo. This doping strategy be applied develop high‐performance, biocompatible, implantable bioelectronics.

Language: Английский

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Ordered porous sulfonic acid MOFs doped poly(3, 4-ethylenedioxythiophene): Toward anticoagulant electrode materials and supercapacitors

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 99, P. 113263 - 113263

Published: Aug. 7, 2024

Language: Английский

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Heparin Doped Polyaniline for Anticoagulation Supercapacitors

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract With the rapid development of implantable electronic medical devices, supercapacitors have gained significant attention as energy storage devices due to their inherent advantages. However, these inevitably direct contact with blood and trigger coagulation or thrombus formation when implanted in body. In severe cases, negative effects compromise functionality system even jeopardize human health. Herein, a biocompatible electrode material high anticoagulant activity is designed by doping polyaniline macromolecule heparin under neutral conditions, which macromolecules dopants conditions not only avoids toxicity acids biological tissues de‐doping caused small molecules, but also imparts properties material. Based on situ polymerization approach, an all‐in‐one anticoagulation supercapacitor employed manufacture exhibits good electrochemical performance (energy density 18.89 µWh cm −2 power 197.8 µW ), cycling stability (capacitance retention 70.23% after 2, 000 cycles), (APTT 15.47 s, PT 16.57 TT 49.47 FIB 1.12 g L −1 tissue compatibility. The strategy provides valuable reference for supply bioelectronics.

Language: Английский

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Advanced implantable energy storage for powering medical devices

eScience, Journal Year: 2025, Volume and Issue: unknown, P. 100409 - 100409

Published: April 1, 2025

Language: Английский

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Poly(3, 4‐Ethylenedioxythiophene) as Promising Energy Storage Materials in Zinc‐Ion Batteries

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(23)

Published: Oct. 29, 2024

Abstract Benefiting from the advantages of high conductivity and good electrochemical stability, conjugated conducting polymer poly (3, 4‐ethylenedioxythiophene) is a promising energy storage material in zinc‐ion batteries. Zinc‐ion batteries have safety, environmental friendliness, low cost, but suffer unstable cathode structure, poor electrical conductivity, uncontrollable dendritic growth zinc anodes. PEDOT, with its fast response wide potential window, expected to make up for shortcomings enhance capacity cycle life Herein, this review different polymerization methods as well their structure properties are summarized; progress doping strategies related increasing dispersivity materials discussed; specific applications 4‐ethylenedioxythiophene)‐based anode, cathode, electrolyte, binder explored; representative advancements improving performance emphasized. Finally, current challenges an insight into future research directions pointed out.

Language: Английский

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