Polydopamine Decorated Hyaluronic Acid Clusters for Tumor Cell Targeting Combination Therapy via Template Self‐Consumption Methods DOI
Hongrui Zhu,

Daqing Xia,

Huan He

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Photothermal‐chemodynamic‐chemotherapy (PTT‐CDT‐CT) combination therapy significantly enhances the therapeutic efficacy against tumors. However, synthesizing PTT‐CDT‐CT nanosystems is complex, typically requiring preparation and conjugation of three components into a single carrier. To overcome this challenge, facile template self‐consumption method developed. In approach, hyaluronic acid (HA), recognized for its tumor cell targeting properties, chelates with Cu 2+ to form Cu‐HA, which then transforms CuO 2 @HA cluster templates. These templates self‐consume gradually, producing ·OH , catalyze rapid polymerization dopamine coordinate polydopamine respectively, enhancing photothermal conversion efficiency. After gossypol loading, GPDA@HA clusters are formed, achieving high loading efficiency due π–π stacking between PDA, as well coordination . The effectively internalized by cells through endocytosis, mediating synergistic damage or inhibition intracellular proteins, nucleic acids via PTT, CDT, CT. Crucially, synergism far surpasses those modality. This work introduces new pathway synthesis nanosystems, avoiding conventional different agents, provides insights developing personalized drug therapies efficacy.

Language: Английский

Metal-chelated polydopamine nanomaterials: Nanoarchitectonics and applications in biomedicine, catalysis, and energy storage DOI
Hong Li, Yi Jia,

Shiwei Bai

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103316 - 103316

Published: Oct. 15, 2024

Language: Английский

Citations

6
Deep co-deposition of polydopamine in PVDF hydrogel to enhance photothermal evaporation efficiency DOI Creative Commons
Yu Ma, Lan Yang, S. WU

et al.

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study introduces a deep co-deposition method to enhance polydopamine (PDA) photo-thermal efficiency by incorporating PDA within membrane internals, increasing loading and improving absorbance, thereby elevating evaporation rate efficiency.

Language: Английский

Citations

0
sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy DOI

Kai‐Yue Song,

Ming Jiang, Bailong Tao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113580 - 113580

Published: Feb. 28, 2025

Language: Английский

Citations

0
Self‐Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal‐Catalytic Therapy Against Melanoma Recurrence and Promote Post‐Surgical Wound Healing DOI Open Access
Hai Zhu, Xinhao Peng, Yanzhuo Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Post‐surgical photothermal therapy for melanoma faces significant challenges including resistance, tumor recurrence, and wound healing. In response, a self‐adaptive hydrogel (VPHCh) is designed, synthesized from carboxymethyl chitosan, integrated with vanadium‐polydopamine (V‐PDA) nanoplatform, which significantly enhances both catalytic properties. The advanced effectively inhibits recurrence facilitates healing through the precise modulation of V‐PDA release dynamics. infection microenvironment, rapidly released, delivering outstanding effects. Furthermore, synergistic actions reactions, induces endoplasmic reticulum stress, disrupting Wnt/β‐catenin signaling pathway enhancing V 5+ ‐mediated glutathione depletion, thereby increasing cell sensitivity to ferroptosis. Importantly, lipid peroxidation during ferroptosis further degradation heat shock protein 90, markedly augmenting effects therapies. Additionally, within VPHCh enables controlled sustained V‐PDA, promoting proliferation, angiogenesis, M2 macrophage polarization, accelerating also exhibits remarkable antibacterial properties, inhibiting bacterial facilitating Consequently, this dynamically adaptive represents promising adjuvant in post‐surgical treatment, offering substantial potential inhibit accelerate

Language: Английский

Citations

0
Boosting photocatalytic oxygen reduction to hydrogen peroxide via chemisorbed oxygen activation on polydopamine-coated zinc oxide DOI

Shuai Dou,

Yuming Dong, Yaning Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137370 - 137370

Published: March 1, 2025

Language: Английский

Citations

0
Durable Antibacterial Photothermal Membrane Using Melanin-Inspired Cu-Doped Polynorepinephrine for Water Remediation DOI
Heng Zhang, Wenxin Qi,

Shang Liu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Solar-driven interfacial evaporation is an efficient approach to addressing water scarcity due its environmental sustainability. However, the prolonged use of solar evaporators causes microbial contamination from wastewater. Inspired by antifouling properties polydopamine, we develop a series mono- and dual-metal-loaded poly(norepinephrine) (PNE) nanoparticles pre-doping multiple metal ions. Metal doping enhances photothermal conversion efficiency (∼60%) PNE reducing energy bandgap imparts antimicrobial properties. Cu

Language: Английский

Citations

3
Conjugated Polymer-Photosensitizers for Cancer Photodynamic Therapy and Their Multimodal Treatment Strategies DOI Open Access
Zhen Cheng,

Qianyi Ye,

Junpeng Lao

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1258 - 1258

Published: May 5, 2025

Conjugated polymers (CPs) have emerged as promising candidates for photodynamic therapy (PDT) in cancer treatment due to their high fluorescence quantum yield, excellent photostability, and remarkable reactive oxygen species (ROS) generation capability. This review systematically summarizes molecular design strategies augment CP photosensitivity efficiency, including: (1) constructing donor–acceptor (D-A) alternating structures, (2) incorporating aggregation-induced emission (AIE) moieties, (3) employing heavy-atom effects, (4) designing hyperbranched architectures. In addition, considering the limitations of monotherapy like tumor heterogeneity, we will further discuss synergistic CP-mediated PDT combination with other therapeutic modalities, including photothermal (PTT)-PDT, immunotherapy-PDT, chemotherapy-PDT, Chemiluminescence (CL)-PDT, diagnostic technology-PDT, chemodynamic (CDT)-PDT. These multimodal approaches leverage complementary mechanisms achieve enhanced eradication efficacy.

Language: Английский

Citations

0
Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy DOI Creative Commons
Zhixin Zhou, Cheng Zhou, Jia Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Traditional chemotherapeutic agents suffer from a lack of selectivity, poor targeting ability, and drug resistance. Developing tumor-specific therapies is crucial for precisely eliminating tumors while circumventing toxicity to normal tissues. Disulfiram (DSF), an FDA-approved treating alcohol dependence, exhibits antitumor effect by forming complexes with copper ions (Cu(DDC)

Language: Английский

Citations

2
Biomimetic Materials for Antibacterial Applications DOI
Junjie Zhang, Heng Dong, Bing Liu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

The rise of antibiotic resistance poses a critical threat to global health, necessitating the development novel antibacterial strategies mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as promising solution in context. These mimicking entities such plants, animals, cells, viruses, and enzymes, offer innovative approaches combat bacterial infections effectively. This review delves into integration biomimicry with materials science develop agents that are not only effective but also biocompatible less likely induce resistance. study explores design function various biomimetic highlighting their therapeutic potential anti-infection applications. Further, provides comprehensive summary recent advancements field, illustrating how these been engineered enhance efficacy safety. discusses challenges facing transition from laboratory clinical settings, scalability, cost-effectiveness, long-term stability. Lastly, vast opportunities hold for future therapy, suggesting continued research multidisciplinary collaboration will be essential realize full potential.

Language: Английский

Citations

1
Exogenous/endogenous stimuli-responsive nanocatalysts trigger in situ chemical reactions for tumor catalytic therapy: An up-to-date mini-review DOI

Kai‐Yue Song,

Cong Jiang, S. C. Huang

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 9(2), P. 189 - 203

Published: Nov. 26, 2024

This mini-review briefly but relatively comprehensively summarizes recent advances in exogenous/endogenous stimuli-responsive nanocatalysts that trigger situ chemical reactions for tumor catalytic therapy, and discusses the future challenges.

Language: Английский

Citations

1