Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy DOI
Mengmeng Jiang,

Shaowen Wu,

Hongxia Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Language: Английский

Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics DOI Creative Commons
Alexandra A.P. Mansur, Herman S. Mansur

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 31, 2025

Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.

Language: Английский

Citations

2
Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

5
Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis DOI Creative Commons
Dong Wang,

Yanli Pan,

Wenzhe Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting regulation presents promising therapeutic strategy for OA; however, current research primarily focuses on single targets associated with ferroptosis. In this study, reactive oxygen species (ROS)‐responsive nanoparticle developed by linking deferasirox (DEF) and pterostilbene (PTE) thioketal incorporating cerium ions (Ce), creating Ce@D&P nanoparticles (NPs), which offer multitarget The characteristics NPs are evaluated their effects IL‐1β‐stimulated chondrocytes verified. Results show that reduce ROS levels, mitigate inflammation, chelate iron to inhibit ferroptosis, balance extracellular matrix (ECM) metabolism chondrocytes. Mechanistically, transcriptomics metabolomics analyses suggest exerted regulating oxidative stress lipid To better treat destabilization medial meniscus (DMM)‐induced mice, via intra‐articular injection delivered. results alleviate cartilage damage slow Overall, findings indicate represent drug delivery system, may be an effective treatment.

Language: Английский

Citations

0
Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy DOI
Mengmeng Jiang,

Shaowen Wu,

Hongxia Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Language: Английский

Citations

0