Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms signaling pathways. In this review, we delve into the cellular metabolic pathways copper, highlighting role copper biomolecule synthesis, mitochondrial respiration, antioxidant defense. Furthermore, elucidate relationship between cuproptosis-related genes (CRGs) cancer prognosis, analyzing their expression patterns across various tumor types impact on patient outcomes. Our review also uncovers potential therapeutic applications chelators, ionophores, copper-based nanomaterials oncology. addition, discuss emerging cuproptosis remodeling microenvironment, enhancing immune infiltration, converting "cold tumors" "hot that respond better to immunotherapy. short, underscores pivotal importance biology highlights translational a novel target.

Language: Английский

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Emerging engineered nanozymes: current status and future perspectives in cancer treatments

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Composite nanozymes are composed of enzymes with similar or different catalytic capabilities and have higher activity than a single enzyme. In recent years, composite emerged as novel nanomaterial platforms for multiple applications in various research fields, where they used to produce oxygen, consume glutathione, toxic reactive oxygen species (ROS) cancer therapy. The therapeutic approach using is known chemo-dynamic therapy (CDT). Some also show special photothermal conversion effects, enabling them be combined pioneering treatments, such photodynamic (PDT), (PTT) sonodynamic (SDT), enhance the anti-cancer effects. this study, classification performances reviewed, along their advantages synthesis methods. Furthermore, treatment cancers emphasized, prospective challenges future discussed.

Language: Английский

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A comprehensive review on the recent applications of nanozymes in breast cancer therapy and diagnosis

Materials Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanozymes have been developed as engineered nanomaterials that mimic the catalytic functions of natural enzymes.

Language: Английский

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Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142798 - 142798

Published: April 1, 2025

Language: Английский

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