Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Recent progress in the 3D printing of microneedle patches for biomedical applications DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995

Published: Nov. 1, 2024

Language: Английский

Citations

4
Wearable, battery-free, and wireless microneedle-based bioelectronics for robustly-integrated chronic wound management and therapeutic diagnosis DOI
Ying Liu, Xiaomin Luo, Liuying Li

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110909 - 110909

Published: March 1, 2025

Language: Английский

Citations

0
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration DOI Creative Commons

Churong Xu,

Fei Wu,

Zhouyi Duan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

Citations

0
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone DOI

Joo‐Young Kim,

Y. J. Um,

Young‐Guk Na

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Nanoscale coordination polymer-coated microneedle patches against bacterial biofilm infection via hypoxia-enhanced copper ion interference therapy DOI

Xinwei Fu,

D. C. Shan,

Jie Liang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158789 - 158789

Published: Dec. 1, 2024

Language: Английский

Citations

1
Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Citations

0