RESPONSIVE TO ADAPTIVE SUPRAMOLECULAR HYDROGELS FOR DIABETIC WOUND TREATMENT. DOI Creative Commons

Shalini Balakrishnan,

Revathy Remesh,

Kalathil K. Kartha

et al.

Supramolecular Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100081 - 100081

Published: Nov. 1, 2024

Language: Английский

Chlorogenic acid-assisted dopamine‑sodium alginate composite nanofiber membranes for promoting wound healing DOI
Meng Zhang, Yang Wang,

Xueling Yin

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 354, P. 123298 - 123298

Published: Jan. 23, 2025

Language: Английский

Citations

0
Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing DOI
Chenguang Liu,

Ronger Ai,

Bizhi Liu

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Language: Английский

Citations

0
Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing DOI Creative Commons
Cencan Xing,

Liangxuan Hou,

Chunbin Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141578 - 141578

Published: Feb. 27, 2025

Language: Английский

Citations

0
A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic wound repair DOI Creative Commons
Zhengduo Zhang,

Yuanyuan Ding,

Huipu Yuan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Language: Английский

Citations

0
RESPONSIVE TO ADAPTIVE SUPRAMOLECULAR HYDROGELS FOR DIABETIC WOUND TREATMENT. DOI Creative Commons

Shalini Balakrishnan,

Revathy Remesh,

Kalathil K. Kartha

et al.

Supramolecular Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100081 - 100081

Published: Nov. 1, 2024

Language: Английский

Citations

3