Triphenylamine‐Substituted Nile Red Derivatives with Efficient Reactive Oxygen Species Generation for Robust and Broad‐Spectrum Antimicrobial Photodynamic Therapy and Abscess Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Infections caused by drug‐resistant bacteria represent a major contributor to high mortality rates, underscoring the urgent need for effective non‐antibiotic drugs and alternative therapies. Antimicrobial photodynamic therapy (aPDT) emerges as an innovative treatment due its minimal drug resistance. Herein, series of Nile Red derivatives is synthesized donor engineering strategy. Notably, NTPA featuring triphenylamine (TPA) electron‐donating group, exhibited highest production reactive oxygen species (ROS). The enhanced electron donating‐accepting (D‐A) property effectively reduced energy gap between S 1 T (ΔE S‐T ), facilitating intersystem crossing (ISC) with larger spin‐orbit coupling (SOC) constant. Furthermore, twisted conformation profoundly suppressed quenching ROS. As expected, over 470‐fold increase in ROS observed, predominantly comprising type‐I nanoparticles (NPs) exceptional vitro killing ability against various bacteria, inhibition efficiency even reaching 99.9%. In methicillin‐resistant staphylococcus aureus (MRSA)‐induced abscess model, NPs facilitated complete wound healing within just 8 days following single administration irradiation, highlighting their bactericidal wound‐healing promotion capabilities. Overall, this work inspired construction efficient Red‐based photosensitizers (PSs) development new broad‐spectrum aPDT method treatment.

Language: Английский

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Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.

Language: Английский

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Engineered extracellular vesicles for tissue repair and regeneration

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Abstract Extracellular vesicles (EVs) are heterogeneous membrane-like secreted by living cells that involved in many physiological and pathological processes act as intermediaries of intercellular communication molecular transfer. Recent studies have shown EVs from specific sources regulate tissue repair regeneration delivering proteins, lipids, nucleic acids to target signaling molecules. Nanotechnology breakthroughs facilitated the development exploration engineered for repair. Enhancements through gene editing, surface modification, content modification further improved their therapeutic efficacy. This review summarizes potential regeneration, mechanisms action, research progress regenerative medicine. highlights design logic typical examples explores prospects The aim this is provide new insights into applications, thereby expanding use

Language: Английский

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Regulatory roles of extracellular vesicles in pregnancy complications

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Extracellular vesicles (EVs) are heterogeneous membranous structures released by various cell types, including large vesicles, microvesicles (MVs), and exosomes. These play crucial roles in intercellular communication within interstitial fluids involved numerous physiological pathological processes. This review aims to examine the regulatory of EVs pregnancy complications, focusing on their involvement gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth (PTB). Placenta- embryo-derived have gained significant attention for biological due effects inflammation, immune response immunomodulation. Recent research highlights importance embryonic development gestation. During pregnancy, several functioned complex endocrine regulation complications that can affect both mother fetus, with long-term cardiovascular metabolic risks. discusses current evidence how modulate outcomes explores pathology GDM, PE, PTB. In spite difficulties relating these findings pathogenesis insufficient clinical practice, potential impact specific proteins miRNAs transported is noteworthy emergence complications. Future should continue explore interactions mediated develop novel diagnostic therapeutic strategies pregnancy-related disorders.

Language: Английский

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Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Extracellular vesicles (EVs) are lipid bilayer nanoparticles naturally released from cells, playing a crucial role in intercellular communication. They modulate gene expression and regulate physiological pathological processes, including acute lung injury (ALI) respiratory distress syndrome (ARDS). Research has shown that EVs contain variety of active components, biocompatible small size, do not trigger immune rejection, making the infusion exogenous promising therapeutic tool. With further research, engineering strategies have been proposed to enhance clinical potential EVs. These involve modifying either donor cells secrete or themselves can be engineered circumvent limitations native In this review, an overview biological properties is provided current treating ALI/ARDS, along with latest research findings, summarized. The challenges opportunities for translation as novel tool also discussed, offering new insights into treatment ALI/ARDS using EV technology.

Language: Английский

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Recent advances in targeted therapy on cancers by nanoparticles encapsulated in exosomes: a comprehensive review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107033 - 107033

Published: May 1, 2025

Language: Английский

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Protective effects of mesenchymal stem cells-derived extracellular vesicles against ischemia-reperfusion injury of hearts donated after circulatory death: Preliminary study in a pig model

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117256 - 117256

Published: Aug. 7, 2024

Language: Английский

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Bacterial Membrane Vesicles as a Novel Vaccine Platform against SARS-CoV-2

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(10)

Published: Aug. 20, 2024

Language: Английский

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