Low‐Crosslinked Hydrophilic Decellularized Adipose Matrix Hydrogels Achieve Efficient and Functional Xenotransplant Fat Regeneration by Optimizing Stem Cell Niche

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Xenogeneic decellularized adipose matrix(DAM) scaffolds are significant in soft tissue regeneration by addressing donor site morbidity and limited availability. However, natural DAM xenotransplantation remains unachieved. Previous efforts have relied on chemical modifications to reduce foreign body reactions, with inherent drawbacks outcomes. This study proposes a hydrogel scaffold that achieves efficient functional xenotransplant fat regeneration. Primarily, hydrophilic DAM(H‐DAM) is confirmed lower antigen content, but its regenerative potential constrained encapsulation impedes seed cell infiltration. Thus, H‐DAM prepared enhance the speed extent of It observed topological structure impacts infiltration, immune inflammatory response, Low‐crosslinked hydrogels emerged as optimal for adipogenic differentiation due loose networks degradation rates synchronizing Furthermore, wall‐like rather than filamentous provides superior niche stem engraftment activity. Finally, integrated multi‐omics data analysis demonstrated regenerated functionally mimics native tissue. These findings indicate xenogeneic gel support both structural reconstruction tissue, offering novel insights promising approach clinical translation DAM‐based therapies.

Language: Английский

Dual-Regulation Biomimetic Composite Nerve Scaffold with Oriented Structure and Conductive Function for Skin Peripheral Nerve Injury Repair

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114768 - 114768

Published: May 6, 2025

Language: Английский

Decellularized adipose-derived matrix from Superficial layers of abdominal adipose tissue exhibits superior capacity of adipogenesis compared to deep layers

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101235 - 101235

Published: Sept. 12, 2024

Language: Английский