Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Perfluorocarbon‐Loaded Hollow Bi₂Se₃ Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer

Advanced Materials, Journal Year: 2016, Volume and Issue: 28(14), P. 2716 - 2723

Published: Feb. 5, 2016

Hollow Bi2 Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, promising concept is demonstrated to enhance radiotherapy not only using their X-ray-absorbing ability locally concentrate radiation energy in the tumor, but also employing near-infrared light trigger burst release of from overcome hypoxia-associated radio-resistance.

Language: Английский

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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease

Current Neuropharmacology, Journal Year: 2020, Volume and Issue: 18(11), P. 1106 - 1125

Published: May 28, 2020

The only conclusive way to diagnose Alzheimer's is carry out brain autopsy of the patient's tissue and ascertain whether subject had or any other form dementia. However, due non-feasibility such methods, conclude conditions, medical practitioners use tests that examine a mental ability.Accurate diagnosis at an early stage need hour for initiation therapy. cause most cases still remains unknown except where genetic distinctions have been observed. Thus, standard drug regimen ensues in every patient, irrespective cause, which may not always be beneficial halting reversing disease progression. To provide better life patients by suppressing existing symptoms, diagnosis, curative therapy, site-specific delivery drugs, application hyphenated methods like artificial intelligence brought into main field therapeutics.In this review, we compiled hypotheses explain disease, highlighted gene immunotherapy, peptidomimetics, metal chelators, probiotics quantum dots as advancements strategies manage Alzheimer's.Biomarkers, brain-imaging, theranostics, along with intelligence, are understood future management Alzheimer's.

Language: Английский

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Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders

Oxidative Medicine and Cellular Longevity, Journal Year: 2018, Volume and Issue: 2018(1)

Published: Jan. 1, 2018

A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s Huntington’s and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, inflammation. Intervention strategies using plant‐derived bioactive compounds have been offered a form treatment for these debilitating conditions, there are currently no remedies to prevent, reverse, or halt the progression loss. Rutin, glycoside flavonoid quercetin, is found in many plants fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, oranges. Pharmacological studies reported beneficial effects rutin disease its therapeutic potential several models NDs has created considerable excitement. Here, we summarized current knowledge on neuroprotective various experimental NDs. The action reviewed this article include reduction proinflammatory cytokines, improved antioxidant enzyme activities, activation mitogen‐activated protein kinase cascade, downregulation mRNA expression PD‐linked proapoptotic genes, upregulation ion transport antiapoptotic restoration activities complex enzymes. Taken together, findings suggest that may be promising compound

Language: Английский

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Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

ACS Nano, Journal Year: 2018, Volume and Issue: 12(2), P. 1321 - 1338

Published: Jan. 24, 2018

Alzheimer's disease (AD) remains an incurable and lacks efficient diagnostic methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due accumulated findings of weak correlation between Aβ deposition cognition, as well failures Phase III clinical trial therapy. Recent studies shown that tau pathway closely associated with development symptoms, which might be a potential therapeutic target. We herein construct methylene blue (MB, aggregation inhibitor) loaded nanocomposite (CeNC/IONC/MSN-T807), not only possesses high binding affinity hyperphosphorylated but also inhibits multiple key pathways tau-associated pathogenesis. demonstrate these nanocomposites can relieve symptoms by mitigating mitochondrial oxidative stress, suppressing hyperphosphorylation, preventing neuronal death both in vitro vivo. The memory deficits rats are significantly rescued upon treatment MB CeNC/IONC/MSN-T807. Our results indicate tau-targeted multifunctional could promising candidate for disease.

Language: Английский

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Therapeutic benefits of rutin and its nanoformulations

Phytotherapy Research, Journal Year: 2020, Volume and Issue: 35(4), P. 1719 - 1738

Published: Oct. 15, 2020

Background Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials. Purpose The current paper is focused on the numerous studies rutin nanoformulations regarding its broad spectrum Study and methods A review was conducted in electronic databases (PubMed) to identify relevant published literature English. No restrictions publication date were imposed. Results search provided 7,078 results for rutin. Among them, 25 papers related potential biological activities nanoformulations. Polymeric nanoparticles most studied (14 titles) lipid (5 second place. reviewed showed that been used antimicrobial, antifungal, anti‐allergic agent. Improving bioavailability using novel drug‐delivery will help investigators use useful effects treatment various chronic human diseases. Conclusion It can be concluded preparation nanomaterials objects confirmed enhanced aqueous solubility well efficacy compared conventional delivery However, more investigations should confirm improved

Language: Английский

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Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease

Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)

Published: June 11, 2021

Abstract Background Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During progression, abnormally phosphorylated forms tau aggregate accumulate into neurofibrillary tangles, leading to synapse loss, neuroinflammation, neurodegeneration. Thus, targeting expected be promising strategy for AD treatment. Methods The effect rutin on aggregation was detected by thioflavin T fluorescence transmission electron microscope imaging. oligomer-induced cytotoxicity assessed MTT assay. oligomer-mediated the production IL-1β TNF-α in vitro measured ELISA. uptake extracellular microglia determined immunocytochemistry. Six-month-old male Tau-P301S mice were treated with or vehicle oral administration daily 30 days. cognitive performance using Morris water maze test, Y-maze novel object recognition test. levels pathological tau, gliosis, NF-kB activation, proinflammatory cytokines such as TNF-α, synaptic proteins including synaptophysin PSD95 brains evaluated immunolabeling, immunoblotting, Results We showed that rutin, natural flavonoid glycoside, inhibited cytotoxicity, lowered cytokines, protected neuronal morphology from toxic oligomers, promoted microglial oligomers vitro. When applied mouse model tauopathy, reduced levels, regulated hyperphosphorylation increasing PP2A level, suppressed gliosis neuroinflammation downregulating pathway, prevented engulfment, rescued loss brains, resulting significant improvement cognition. Conclusion In combination previously reported therapeutic effects Aβ pathology, drug candidate treatment based its combinatorial Aβ.

Language: Английский

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Natural polyphenols in drug delivery systems: Current status and future challenges

Giant, Journal Year: 2020, Volume and Issue: 3, P. 100022 - 100022

Published: Aug. 1, 2020

Natural polyphenols have attracted great interests in medicine, food and cosmetics due to their versatile functions such as antioxidant, anticancer antibacterial. The polyphenolic structures (i.e. catechol, pyrogallol) natural are responsible for strong noncovalent interactions via multiple hydrogen bonding hydrophobic interactions, dynamic covalent complexation with boronate groups metal ions. In this review, we focused on the preparation applications of polyphenol-based coating films, nanoparticles, nanocapsules, hydrogels emerged from chemical functional signatures. beneficial role mechanism facilitating delivery proteins, nucleic acids conventional drug molecules were reviewed. Finally, challenges systems perspectives rational design next generation polyphenol biomaterials will be discussed.

Language: Английский

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Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(15), P. 4109 - 4128

Published: Jan. 1, 2020

With an aging population that has been increasing in recent years, the need for development of therapeutic approaches treatment neurodegenerative disorders (ND) increased. ND, which are characterized by progressive loss structure or function neurons, often associated with neuronal death. In spite screening numerous drugs, currently there is no specific can cure these diseases slow down their progression. Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Huntington's disease, and prion belong to ND affect enormous numbers people globally. There some main possible reasons failure such as limitations introduced Blood-Brain Barrier (BBB), Blood-Cerebrospinal Fluid (BCFB) P-glycoproteins. Current advances nanotechnology present opportunities overcome mentioned using designing nanomaterials improving delivery active drug candidates. Some basic developing strategies impediments local receptor-mediated transcytosis, physicochemical disruption BBB, cell-penetrating peptides magnetic disruption. Recently, application nanoparticles developed improve efficiency delivery. Nanoengineered particles nanodrugs possess capacity cross BBB also show decreased invasiveness. Examples include inorganic, magnetic, polymeric carbonic have efficiency. Despite papers published this filed, unsolved issues be addressed successful diseases. These discussed herein.

Language: Английский

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Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(10), P. 3988 - 4024

Published: July 16, 2023

In recent years, growing awareness of the role oxidative stress in brain health has prompted antioxidants, especially dietary to receive attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied antioxidants include active substances such vitamins, carotenoids, flavonoids and polyphenols. Dietary are found usually consumed foods fresh fruits, vegetables, nuts oils gaining popularity due recently their potential preventive protective agents against NDs, well abundant natural sources, generally non-toxic nature, ease long-term consumption. This review article examines development explores ‘two-sidedness’ blood–brain barrier (BBB) a nervous system an impeding use drug medicinal products and/or supplements prevention therapy reviews BBB permeability common suplements efficacy treatment NDs. Finally, current challenges future directions NDs using discussed, useful information on is provided.

Language: Английский

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