Plants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 965 - 965
Published: March 27, 2024
In
recent
years,
discovering
new
drug
candidates
has
become
a
top
priority
in
research.
Natural
products
have
proven
to
be
promising
source
for
such
discoveries
as
many
researchers
successfully
isolated
bioactive
compounds
with
various
activities
that
show
potential
candidates.
Among
these
compounds,
phenolic
been
frequently
due
their
biological
activities,
including
role
antioxidants,
making
them
treating
diseases
related
oxidative
stress.
The
isolation
method
is
essential,
and
sought
find
effective
procedures
maximize
the
purity
yield
of
compounds.
This
review
aims
provide
information
on
or
separation
methods
antioxidant
using
column
chromatography,
medium-pressure
liquid
high-performance
counter-current
hydrophilic
interaction
supercritical
fluid
molecularly
imprinted
technologies,
thin
layer
chromatography.
For
purification,
technologies
represent
more
accessible
efficient
procedure
because
they
can
applied
directly
extract
reduce
complicated
process.
However,
it
still
requires
further
development
refinement.
Journal of Clinical Medicine,
Journal Year:
2019,
Volume and Issue:
9(1), P. 109 - 109
Published: Dec. 31, 2019
Among
natural
substances
widespread
in
fruits,
vegetables,
spices,
and
medicinal
plants,
flavonoids
organic
acids
belong
to
the
promising
groups
of
bioactive
compounds
with
strong
antioxidant
anti-inflammatory
properties.
The
aim
present
work
was
evaluate
antibacterial
activity
13
common
(flavones,
flavonols,
flavanones)
6
(aliphatic
aromatic
acids).
minimal
inhibitory
concentrations
(MICs)
selected
plant
were
determined
by
micro-dilution
method
using
clinical
strains
four
species
pathogenic
bacteria.
All
tested
showed
antimicrobial
properties,
but
their
biological
moderate
or
relatively
low.
Bacterial
growth
most
strongly
inhibited
salicylic
acid
(MIC
=
250–500
μg/mL).
These
generally
more
active
against
Gram-negative
bacteria:
Escherichia
coli
Pseudomonas
aeruginosa
than
Gram-positive
ones:
Enterococcus
faecalis
Staphylococcus
aureus.
An
analysis
effect
flavone,
chrysin,
apigenin,
luteolin
that
presence
hydroxyl
phenyl
rings
A
B
usually
did
not
influence
on
level
activity.
significant
increase
hydroxy
derivatives
flavone
observed
only
for
S.
Similarly,
position
sugar
group
glycosides
had
no
MIC
values.
Phytotherapy Research,
Journal Year:
2020,
Volume and Issue:
35(4), P. 1719 - 1738
Published: Oct. 15, 2020
Background
Rutin
as
a
natural
flavonoid
compound
has
revealed
an
extensive
range
of
therapeutic
potentials.
Purpose
The
current
paper
is
focused
on
the
numerous
studies
rutin
nanoformulations
regarding
its
broad
spectrum
Study
and
methods
A
review
was
conducted
in
electronic
databases
(PubMed)
to
identify
relevant
published
literature
English.
No
restrictions
publication
date
were
imposed.
Results
search
provided
7,078
results
for
rutin.
Among
them,
25
papers
related
potential
biological
activities
nanoformulations.
Polymeric
nanoparticles
most
studied
(14
titles)
lipid
(5
second
place.
reviewed
showed
that
been
used
antimicrobial,
antifungal,
anti‐allergic
agent.
Improving
bioavailability
using
novel
drug‐delivery
will
help
investigators
use
useful
effects
treatment
various
chronic
human
diseases.
Conclusion
It
can
be
concluded
preparation
nanomaterials
objects
confirmed
enhanced
aqueous
solubility
well
efficacy
compared
conventional
delivery
However,
more
investigations
should
confirm
improved
Cancers,
Journal Year:
2020,
Volume and Issue:
12(8), P. 2276 - 2276
Published: Aug. 14, 2020
Multiple
dysregulated
signaling
pathways
are
implicated
in
the
pathogenesis
of
cancer.
The
conventional
therapies
used
cancer
prevention/treatment
suffer
from
low
efficacy,
considerable
toxicity,
and
high
cost.
Hence,
discovery
development
novel
multi-targeted
agents
to
attenuate
is
great
importance.
In
recent
decades,
phytochemicals
dietary
medicinal
plants
have
been
successfully
introduced
as
alternative
anticancer
due
their
ability
modulate
numerous
oncogenic
oncosuppressive
pathways.
Rutin
(also
known
rutoside,
quercetin-3-O-rutinoside
sophorin)
an
active
plant-derived
flavonoid
that
widely
distributed
various
vegetables,
fruits,
plants,
including
asparagus,
buckwheat,
apricots,
apples,
cherries,
grapes,
grapefruit,
plums,
oranges,
tea.
has
shown
target
inflammatory,
apoptotic,
autophagic,
angiogenic
mediators,
nuclear
factor-κB,
tumor
necrosis
factor-α,
interleukins,
light
chain
3/Beclin,
B
cell
lymphoma
2
(Bcl-2),
Bcl-2
associated
X
protein,
caspases,
vascular
endothelial
growth
factor.
A
comprehensive
critical
analysis
potential
rutin
molecular
targets
amongst
types
not
performed
previously.
Accordingly,
purpose
this
review
present
up-to-date
evaluation
multiple
cellular
mechanisms
through
which
effects
be
exerted.
current
challenges
limitations
well
future
directions
research
also
discussed.
Microorganisms,
Journal Year:
2021,
Volume and Issue:
9(1), P. 197 - 197
Published: Jan. 19, 2021
Fungal
endophytes
are
well-established
sources
of
biologically
active
natural
compounds
with
many
producing
pharmacologically
valuable
specific
plant-derived
products.
This
review
details
typical
medicinal
several
classes,
including
alkaloids,
coumarins,
flavonoids,
glycosides,
lignans,
phenylpropanoids,
quinones,
saponins,
terpenoids,
and
xanthones
that
produced
by
endophytic
fungi.
covers
the
studies
carried
out
since
first
report
taxol
biosynthesis
Taxomyces
andreanae
in
1993
up
to
mid-2020.
The
article
also
highlights
prospects
endophyte-dependent
such
bottlenecks
commercialization
this
novel
approach
area
drug
discovery.
After
recent
updates
field
'omics'
'one
strain
compounds'
(OSMAC)
approach,
fungal
have
emerged
as
strong
unconventional
source
prized
Frontiers in Molecular Biosciences,
Journal Year:
2021,
Volume and Issue:
7
Published: Jan. 19, 2021
Historically,
plants
have
been
sought
after
as
bio-factories
for
the
production
of
diverse
chemical
compounds
that
offer
a
multitude
possibilities
to
cure
diseases.
To
combat
current
pandemic
coronavirus
disease
2019
(COVID-19),
plant-based
natural
are
explored
their
potential
inhibit
SARS-CoV-2
(severe
acute
respiratory
syndrome
2),
cause
COVID-19.
The
present
study
is
aimed
at
investigation
antiviral
action
several
groups
phytoconstituents
against
using
molecular
docking
approach
Main
Protease
(Mpro)
(PDB
code:
6LU7)
and
spike
(S)
glycoprotein
receptor
binding
domain
(RBD)
ACE2
6M0J)
SARS-CoV-2.
For
affinity
evaluation,
scores
were
calculated
Extra
Precision
(XP)
protocol
Glide
module
Maestro.
CovDock
was
also
used
investigate
covalent
docking.
OPLS3e
force
field
in
simulations.
score
by
preferring
conformation
ligand
has
lowest
free
energy
(best
pose).
results
indicative
better
solanine,
acetoside,
rutin,
Mpro
RBD
dual
inhibitors.
Acetoside
curcumin
found
covalently.
Curcumin
possessed
all
physicochemical
pharmacokinetic
parameters
range.
Thus,
phytochemicals
like
hold
be
developed
treatment
options
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: April 12, 2023
Abstract
In
recent
years,
mesoporous
silica
nanoparticles
(MSNs)
have
been
applied
in
various
biomedicine
fields
like
bioimaging,
drug
delivery,
and
antibacterial
alternatives.
MSNs
could
be
manufactured
through
green
synthetic
methods
as
environmentally
friendly
sustainable
synthesis
approaches,
to
improve
physiochemical
characteristics
for
biomedical
applications.
the
present
research,
we
used
Rutin
(Ru)
extract,
a
biocompatible
flavonoid,
reducing
agent
nonsurfactant
template
of
Ag-decorated
MSNs.
Transmission
electron
microscopy
(TEM),
zeta-potential,
x-ray
powder
diffraction
(XRD),
fourier
transform
infrared
(FTIR)
spectroscopy
analysis,
scanning
(SEM),
brunauer–emmett–teller
(BET)
energy-dispersive
system
(EDS)
were
evaluate
physical
characteristics.
The
antimicrobial
properties
evaluated
against
Staphylococcus
aureus
(S
.
aureus),
Escherichia
coli
(
E
coli),
also
different
types
candida.
cytotoxicity
test
was
performed
by
using
MTT
assay.
Based
on
findings,
significant
efficacy
Ru-Ag-decorated
both
gram
positive
negative
bacteria
fungi
detected
well
acceptable
safety
low
even
at
lower
concentrations.
Our
results
given
straightforward
cost-effective
method
fabricating
biodegradable
applications
these
domains
appear
promising.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 880 - 880
Published: April 4, 2023
Oxidative
stress
causes
various
diseases,
such
as
type
II
diabetes
and
dyslipidemia,
while
antioxidants
in
foods
may
prevent
a
number
of
diseases
delay
aging
by
exerting
their
effects
vivo.
Phenolic
compounds
are
phytochemicals
flavonoids
which
consist
flavonols,
flavones,
flavanonols,
flavanones,
anthocyanidins,
isoflavones,
lignans,
stilbenoids,
curcuminoids,
phenolic
acids,
tannins.
They
have
hydroxyl
groups
molecular
structures.
These
present
most
plants,
abundant
nature,
contribute
to
the
bitterness
color
foods.
Dietary
compounds,
quercetin
onions
sesamin
sesame,
exhibit
antioxidant
activity
help
cell
diseases.
In
addition,
other
kinds
tannins,
larger
weights,
many
unexplained
aspects
still
exist.
The
activities
be
beneficial
for
human
health.
On
hand,
metabolism
intestinal
bacteria
changes
structures
these
with
properties,
resulting
metabolites
exert
recent
years,
it
has
become
possible
analyze
composition
microbiota.
augmentation
microbiota
intake
been
implicated
disease
prevention
symptom
recovery.
Furthermore,
"brain-gut
axis",
is
communication
system
between
gut
microbiome
brain,
attracting
increasing
attention,
research
revealed
that
dietary
affect
brain
homeostasis.
this
review,
we
discuss
usefulness
against
some
biotransformation
microbiota,
microflora,
on
brain-gut
axis.
