ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(6), P. 6470 - 6497
Published: May 22, 2020
As
a
class
of
carbon-based
nanomaterials,
carbon
dots
(CDs)
have
attracted
enormous
attention
because
their
tunable
optical
and
physicochemical
properties,
such
as
absorptivity
photoluminescence
from
ultraviolet
to
near-infrared,
high
photostability,
biocompatibility,
aqueous
dispersity.
These
characteristics
make
CDs
promising
alternative
photonic
nanoagent
conventional
fluorophores
in
disease
diagnosis,
treatment,
healthcare
managements.
This
review
describes
the
fundamental
photophysical
properties
highlights
recent
applications
bioimaging,
photomedicine
(e.g.,
photodynamic/photothermal
therapies),
biosensors,
devices.
We
discuss
current
challenges
future
prospects
give
an
insight
into
developing
vibrant
fields
CD-based
biomedicine
healthcare.
Nanoscale,
Journal Year:
2019,
Volume and Issue:
11(41), P. 19214 - 19224
Published: Jan. 1, 2019
We
highlight
the
recent
progress
in
practical
applications
of
C-Dots,
with
particular
attention
to
research
light-emitting
devices,
bioimaging
and
biodetection,
catalysis,
functional
materials,
agriculture.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(3), P. 1666 - 1762
Published: Dec. 28, 2018
Organic/inorganic
nanohybrids
have
attracted
widespread
interests
due
to
their
favorable
properties
and
promising
applications
in
biomedical
areas.
Great
efforts
been
made
design
fabricate
versatile
nanohybrids.
Among
different
organic
components,
diverse
polymers
offer
unique
avenues
for
multifunctional
systems
with
collective
properties.
This
review
focuses
on
the
design,
properties,
of
organic/inorganic
fabricated
from
inorganic
nanoparticles
polymers.
We
begin
a
brief
introduction
variety
strategies
fabrication
functional
Then
functions
are
discussed,
including
parts,
synergistic
morphology-dependent
self-assembly
After
that,
current
situations
applied
imaging,
therapy,
imaging-guided
therapy
demonstrated.
Finally,
we
discuss
prospect
highlight
challenges
opportunities
future
investigations.
Advanced Healthcare Materials,
Journal Year:
2019,
Volume and Issue:
8(14)
Published: June 26, 2019
Abstract
The
emergence
of
multidrug
resistant
bacterial
strains
has
hastened
the
exploration
advanced
microbicides
and
antibacterial
techniques.
Photodynamic
therapy
(PDAT),
an
old‐fashioned
technique,
been
rejuvenated
to
combat
“superbugs”
biofilm‐associated
infections
owing
its
excellent
characteristics
noninvasiveness
broad
spectrum.
More
importantly,
bacteria
are
less
likely
produce
drug
resistance
PDAT
because
it
does
not
require
specific
targeting
interaction
between
photosensitizers
(PSs)
bacteria.
This
review
mainly
focuses
on
recent
developments
future
prospects
PDAT.
mechanisms
against
biofilms
briefly
introduced.
In
addition
classical
macrocyclic
PSs,
several
innovative
including
non‐self‐quenching
conjugated
polymer–based
nano‐PSs,
summarized
in
detail.
Numerous
multifunctional
systems
such
as
situ
light‐activated
PDAT,
stimuli‐responsive
oxygen
self‐enriching
enhanced
PDAT‐based
multimodal
highlighted
overcome
inherent
defects
vivo
(e.g.,
limited
penetration
depth
light
hypoxic
environment
infectious
sites).
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(35)
Published: July 17, 2018
Extreme
hypoxia
of
tumors
represents
the
most
notable
barrier
against
advance
tumor
treatments.
Inspired
by
biological
nature
red
blood
cells
(RBCs)
as
primary
oxygen
supplier
in
mammals,
an
aggressive
man-made
RBC
(AmmRBC)
is
created
to
combat
hypoxia-mediated
resistance
photodynamic
therapy
(PDT).
Specifically,
complex
formed
between
hemoglobin
and
enzyme-mimicking
polydopamine,
polydopamine-carried
photosensitizer
encapsulated
inside
biovesicle
that
engineered
from
recombined
membranes.
The
mean
corpuscular
AmmRBCs
reaches
about
tenfold
high
natural
RBCs.
Owing
same
origin
outer
membranes,
share
excellent
biocompatibility
with
parent
introduced
polydopamine
plays
role
antioxidative
enzymes
existing
RBCs
effectively
prevent
oxygen-carrying
oxidation
damage
during
circulation.
This
biomimetic
engineering
can
accumulate
tumors,
permit
situ
efficient
supply,
impose
strong
PDT
efficacy
toward
extremely
hypoxic
complete
elimination.
pseudo-RBC
shows
potentials
a
universal
oxygen-self-supplied
platform
sensitize
hypoxia-limited
treatment
means,
including
but
not
limited
PDT.
Meanwhile,
this
study
offers
ideas
production
artificial
substitutes
packed
for
clinical
transfusion.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
Nano Letters,
Journal Year:
2019,
Volume and Issue:
19(7), P. 4334 - 4342
Published: June 10, 2019
Nanozymes
as
artificial
enzymes
that
mimicked
natural
enzyme-like
activities
have
received
great
attention
in
cancer
diagnosis
and
therapy.
Biomimetic
nanozymes
require
more
consideration
regarding
complicated
tumor
microenvironments
to
mimic
biological
enzymes,
thus
achieving
superior
nanozyme
activity
vivo.
Here
we
report
a
biomimetic
hybrid
(named
rMGB)
which
integrates
enzyme
glucose
oxidase
(GOx)
with
manganese
dioxide
(MnO2)
by
mutual
promotion
for
maximizing
the
enzymatic
of
MnO2
GOx.
Under
hypoxia
environment,
observed
could
react
endogenous
H2O2
produce
O2
enhancing
catalytic
efficiency
GOx
starvation
Meanwhile,
confirmed
oxidation
generated
gluconic
acid
further
improved
subsequently.
The
biochemical
reaction
cycle,
consisting
MnO2,
O2,
GOx,
H+,
was
triggered
microenvironment
accelerated
each
other
so
achieve
self-supplied
H+
accelerate
generation,
therapy,
alleviating
accelerating
reactive
oxygen
species
generation
photodynamic
This
would
facilitate
development
treatment.
