Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

ACS Nano, Journal Year: 2019, Volume and Issue: 13(8), P. 8537 - 8565

Published: Aug. 1, 2019

As a mussel-inspired material, polydopamine (PDA), possesses many properties, such as simple preparation process, good biocompatibility, strong adhesive property, easy functionalization, outstanding photothermal conversion efficiency, and quenching effect. PDA has attracted increasingly considerable attention because it provides versatile approach to functionalize material surfaces for obtaining variety of multifunctional nanomaterials. In this review, recent significant research developments including its synthesis polymerization mechanism, physicochemical different nano/microstructures, diverse applications are summarized discussed. For the sections in surface modification biomedicine, we mainly highlight achievements past few years (2016–2019). The remaining challenges future perspectives PDA-based nanoplatforms discussed rationally at end. This timely overall review should be desirable wide range scientists facilitate further development coating methods production materials.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(12), P. 12181 - 12192

Published: Nov. 20, 2018

Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering intervene tumorous metabolism for enhanced ferroptosis. Fe3+ ion and naturally derived tannic acid (TA) spontaneously form network-like corona onto sorafenib (SRF) nanocores. The formed SRF@FeIIITA nanoparticles can respond lysosomal environment dissociation, permitting SRF release inhibit GPX4 enzyme initiation. TA arranged chemically reduce liberated ferroptosis-generated Fe2+, offering redox cycling to, thus, effectively produce lipid peroxide required in Sustained Fe2+ supply leads long-term cytotoxicity, which identified be specific H2O2-overloaded cancer cells but minimal normal cells. SRF@FeIIITA-mediated cell death proves follow pathway strongly inhibits tumor proliferation. Moreover, provides powerful platform capable versatile integration between apoptosis non-apoptosis Typically, photosensitizer-adsorbed demonstrates rapid imaging owing acid-responsive fluorescence recovery. Together ferroptosis, imaging-guided photodynamic therapy induces complete elimination. This study ideas about how advance anticancer through rational material design.

Language: Английский

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Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

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Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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Ultrasound‐Activated Sensitizers and Applications

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(34), P. 14212 - 14233

Published: July 3, 2019

Modalities for photo-triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic (SDT), which is different from photodynamic (PDT) the use of highly penetrating acoustic waves to activate a class sound-responsive materials called sonosensitizers, has gained significant interest in recent years. The effect SDT closely related structural and physicochemical properties led development new sound-activated as sonosensitizers various biomedical applications. This Review provides summary discussion types novel developed last few years outlines specific designs potential challenges. applications with functions such imaging drug delivery well combination other treatment modalities would provide strategies disease therapy.

Language: Английский

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Nanoparticles modified by polydopamine: Working as “drug” carriers

Bioactive Materials, Journal Year: 2020, Volume and Issue: 5(3), P. 522 - 541

Published: April 18, 2020

Inspired by the mechanism of mussel adhesion, polydopamine (PDA), a versatile polymer for surface modification has been discovered. Owing to its unique properties like extraordinary adhesiveness, excellent biocompatibility, mild synthesis requirements, as well distinctive drug loading approach, strong photothermal conversion capacity and reactive oxygen species (ROS) scavenging facility, various PDA-modified nanoparticles have desired carriers. These with diverse nanostructures are exploited in multifunctions, consisting targeting, imaging, chemical treatment (CT), photodynamic therapy (PDT), (PTT), tissue regeneration ability, therefore attracted great attentions plenty biomedical applications. Herein, recent progress nanoparticle carriers cancer therapy, antibiosis, prevention inflammation, theranostics, vaccine delivery adjuvant, repair implant materials reviewed, including preparation their strategies, basic roles PDA modification, etc. The advantages overcoming existing limitations developing trends future also discussed.

Language: Английский

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Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 3414 - 3425

Published: March 10, 2020

Photodynamic therapy (PDT) combined with oxygenating strategies is widely employed in cancer treatment; however, oxygen-boosted PDT has failed to achieve an ideal effect due the complexity, heterogeneity, and irreversible hypoxic environment generated by tumor tissues. With emergence of Fe-dependent ferroptosis boasting reactive oxygen species (ROS) cytotoxicity as well, such a chemodynamic approach drawn extensive attention. In this study, hemoglobin (Hb) connected photosensitizer chlorin e6 (Ce6) construct 2-in-1 nanoplatform (SRF@Hb-Ce6) Sorafenib (SRF, promotor) loaded, combining potent ferroptosis. Benefiting from intrinsic presence Fe capable binding oxygen, concurrently furnishes for oxygen-dependent Furthermore, amphiphilic MMP2-responsive peptide incorporated into skeleton ensure drug-release specificity safety improvement. Correlative measurements demonstrate potentiation SRF@Hb-Ce6. More importantly, strengthens recruiting immune cells secrete IFN-γ, which can sensitize our findings. The therapeutic synergistic treatment SRF@Hb-Ce6 vitro vivo was proven significant, revealing promising prospects nanoplatform.

Language: Английский

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Biomimetic Hybrid Nanozymes with Self-Supplied H⁺ and Accelerated O₂ Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

Nano Letters, Journal Year: 2019, Volume and Issue: 19(7), P. 4334 - 4342

Published: June 10, 2019

Nanozymes as artificial enzymes that mimicked natural enzyme-like activities have received great attention in cancer diagnosis and therapy. Biomimetic nanozymes require more consideration regarding complicated tumor microenvironments to mimic biological enzymes, thus achieving superior nanozyme activity vivo. Here we report a biomimetic hybrid (named rMGB) which integrates enzyme glucose oxidase (GOx) with manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic of MnO2 GOx. Under hypoxia environment, observed could react endogenous H2O2 produce O2 enhancing catalytic efficiency GOx starvation Meanwhile, confirmed oxidation generated gluconic acid further improved subsequently. The biochemical reaction cycle, consisting MnO2, O2, GOx, H+, was triggered microenvironment accelerated each other so achieve self-supplied H+ accelerate generation, therapy, alleviating accelerating reactive oxygen species generation photodynamic This would facilitate development treatment.

Language: Английский

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