Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 332, P. 312 - 336

Published: Feb. 27, 2021

Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related drug administration, from the low water-solubility poor permeability across biological barriers. With respect other nanocarriers, polymeric micelles generally display smaller size, easier preparation and sterilization processes, good solubilization properties, unfortunately associated with a lower stability fluids more complicated characterization. Particularly challenging is study their interaction environment, essential predict real vivo behavior after administration. In this review, general presentation on features different characterization techniques are discussed, ones used for determination basic characteristics (critical micellar concentration, surface charge, morphology) complex approaches figure out kinetic stability, release presence substrates (fluids, cells tissues). The presented (such as dynamic light scattering, AFM, cryo-TEM, X-ray FRET, symmetrical flow field-flow fractionation (AF4) density ultracentrifugation), each one own advantages limitations, can be combined achieve deeper comprehension behavior. set-up validation adequate methods description starting point development clinical success.

Language: Английский

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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Theranostics, Journal Year: 2020, Volume and Issue: 10(10), P. 4557 - 4588

Published: Jan. 1, 2020

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors diseased regions increase specificity of drug delivery. Currently, numerous nanocarriers have engineered with changes responding external stimuli, such as ultrasound, thermal, light magnetic field, well internal including pH, redox potential, hypoxia enzyme, etc. Nanocarriers respond stimuli tumor microenvironments or inside cancer cells for on-demanded delivery accumulation, controlled release, activation bioactive compounds, probes targeting ligands, size, charge conformation conversion, etc., leading sensing signaling, overcoming multidrug resistance, accurate diagnosis precision therapy. This review summarized general strategies developing advances, presented their applications delivery, imaging, therapy theranostics, illustrated clinical translation made prospects.

Language: Английский

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Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy

ACS Nano, Journal Year: 2019, Volume and Issue: 13(11), P. 13015 - 13026

Published: Nov. 5, 2019

Overcoming the reticuloendothelial system (RES) has long been a vital challenge to nanoparticles as drug carriers. Modification of with polyethylene glycol helps them avoid clearance by macrophages but also suppresses their internalization target cells. To overcome this paradox, we developed an RES-specific blocking utilizing "don't-eat-us" strategy. First, CD47-derived, enzyme-resistant peptide ligand was designed and placed on liposomes (d-self-peptide-labeled liposome, DSL). After mainline administration, DSL quickly adsorbed onto hepatic phagocyte membranes (including those Kupffer cells liver sinusoidal endothelial cells), forming long-lasting mask that enclosed cell thus reducing interactions between phagocytes subsequently injected nanoparticles. Compared blank conventional (CL), blocked RES at much lower dose, effect sustained for longer time, highly prolonging elimination half-life This strategy further verified brain-targeted delivery against cryptococcal meningitis model, providing dramatically enhanced brain accumulation targeted superior therapeutic outcome model Amphotericin B compared CL. Our study demonstrates blocks masking surfaces prolong nanoparticle circulation time without excess modification illustrates its utility in enhancing delivery.

Language: Английский

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Hierarchical micro/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration

Biomaterials, Journal Year: 2019, Volume and Issue: 227, P. 119555 - 119555

Published: Oct. 18, 2019

Language: Английский

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Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 30, 2022

Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for guided therapy (SDT). It is challenging, however, to realize a single material that simultaneously endowed both NIR emitting activities. Herein, we report the design of class NIR-emitting from phosphorescent carbon dot (CD) narrow bandgap (1.62 eV) long-lived excited triplet states (11.4 μs), two which can enhance SDT as thermodynamically dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs identified bipolar quantum dots containing p- n-type surface functionalization regions drive spatial separation e--h+ pairs fast transfer reaction sites. Importantly, cancer-specific targeting high-level intratumor enrichment theranostic achieved by cancer cell membrane encapsulation precision complete eradication solid tumors injection irradiation. These results will open up promising approach engineer materials tumor therapy.

Language: Английский

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Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 143(2), P. 538 - 559

Published: Dec. 28, 2020

The past few decades have witnessed an evolution of nanomedicine from biologically inert entities to more smart systems, aimed at advancing in vivo functionality. However, we should recognize that most systems still rely on reasonable explanation-including some over-explanation-rather than definitive evidence, which is a watershed radically determining the speed and extent nanomedicine. Probing nano-bio interactions desirable functionality tissue, cellular, molecular levels frequently overlooked. Progress toward answering these questions will provide instructive insight guiding effective chemo-physical strategies. Thus, next generation, argue much effort be made evidence for proof-of-mechanism, lieu creating many new complicated similar proof-of-concept.

Language: Английский

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Cancer‐Cell‐Activated in situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(27), P. 14945 - 14953

Published: April 22, 2021

Maximization of phototoxic damage on tumor with minimized side effect normal tissue is essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer-cell-specific or even cancer-cell-organelle-specific synthesis delivery efficient photosensitizers (PSs) in vitro and vivo, which difficult to achieve. Herein, we report a strategy cancer-cell-activated PS synthesis, by an mitochondria-targeting photosensitizer aggregation-induced-emission (AIE) feature can be selectively synthesized as image-guided PDT agent inside cancer cells. MOF-199, CuII -based metal-organic framework, was selected inert carrier load the precursors served CuI catalyst source situ click reaction form PSs exclusively The showed capability, allowing potent ablation under light irradiation. high specificity produced cells also makes it safer post-treatment.

Language: Английский

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Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2020, Volume and Issue: 13(2)

Published: Sept. 19, 2020

Dendritic polymers have highly branched three-dimensional architectures, the fourth type apart from linear, cross-linked, and one. They possess not only a large number of terminal functional units interior cavities, but also low viscosity with weak or no entanglement. These features endow them great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay bioimaging. Most review articles related to bio-related applications dendritic focus on their while very few are devoted function as cancer diagnosis agents, which essential for treatment. In this review, we will provide comprehensive insights into polymer-based agents. Their classification preparation presented readers precise understanding polymers. On account physical/chemical properties biological cancer, suggest design strategies constructing such active passive targeting strategies, imaging reporters-incorporating and/or internal stimuli-responsive degradable/enhanced strategies. recent vitro cells exosomes vivo primary metastasis tumor sites aid single/multiple modalities be discussed detail. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Nanodiagnostics Imaging Nanoparticle-Based Sensing.

Language: Английский

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Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 329, P. 676 - 695

Published: Oct. 3, 2020

Language: Английский

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Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 211 - 241

Published: Oct. 21, 2022

Language: Английский

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