Ferroptosis in cancer and cancer immunotherapy

Cancer Communications, Journal Year: 2022, Volume and Issue: 42(2), P. 88 - 116

Published: Feb. 1, 2022

Abstract The hallmark of tumorigenesis is the successful circumvention cell death regulation for achieving unlimited replication and immortality. Ferroptosis a newly identified type dependent on lipid peroxidation which differs from classical programmed in terms morphology, physiology biochemistry. broad spectrum injury tumor tolerance are main reasons radiotherapy chemotherapy failure. effective rate immunotherapy as new treatment method less than 30%. can be seen radiotherapy, chemotherapy, immunotherapy; therefore, ferroptosis activation may potential strategy to overcome drug resistance mechanism traditional cancer treatments. In this review, characteristics causes by briefly described. addition, three metabolic regulations its crosstalk with signaling pathways summarized. Collectively, these findings suggest vital role based interaction immunotherapy, thus, indicating remarkable treatment.

Language: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(3), P. 1167 - 1195

Published: Jan. 1, 2022

This review presents an up-to-date state of the art on first-row-transition metal complexes, from titanium to zinc, in regard their applications as photosensitisers for phototherapeutic applications.

Language: Английский

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Copper-based metal–organic frameworks for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102686 - 102686

Published: April 29, 2022

Language: Английский

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The Current Status of Photodynamic Therapy in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 585 - 585

Published: Jan. 18, 2023

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.

Language: Английский

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Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(10), P. 4667 - 4677

Published: March 7, 2022

Constructing artificial dynamic architectures inside cells to rationally interfere with organelles is emerging as an efficient strategy regulate the behaviors and fate of cells, thus providing new routes for therapeutics. Herein, we develop intracellular K+-mediating assembly DNA tetrahedrons which realizes mitochondrial interference consequent regulation on energy metabolism living cells. In designer tetrahedron, one vertex was modified triphenylphosphine (TPP) targeting, other three vertexes were tethered guanine-rich sequences that could realize formation intermolecular G-quadruplexes, consequently led form aggregates in cytoplasm. The specially targeted mitochondria served a polyanionic barrier substance communication, generating significant inhibition effect aerobic respiration function associated glycolysis process, reduced production adenosine triphosphate (ATP). lack ATP impeded lamellipodium essential movement resulting inhibitory cell migration. Remarkably, migration capacity suppressed by high 50% cancer This work provides manipulation via endogenous molecule-mediating exogenous envisioned have great potential precise biomedicine.

Language: Английский

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Metal-organic framework nanoagent induces cuproptosis for effective immunotherapy of malignant glioblastoma

Nano Today, Journal Year: 2023, Volume and Issue: 51, P. 101911 - 101911

Published: June 16, 2023

Language: Английский

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Mitochondria-targeted smart AIEgens: Imaging and therapeutics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214818 - 214818

Published: Sept. 21, 2022

Language: Английский

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Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Aggregate, Journal Year: 2023, Volume and Issue: 4(5)

Published: May 6, 2023

Abstract Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to advantages large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared demonstrated deep penetration suitable signal‐to‐noise ratio, which allows reliable vivo imaging. Combined with other modalities, multimodal could provide multidimensional hallmarks from perspectives. In addition, phototherapy be photodynamic therapy photothermal therapy, facilitate ablation cells good biosafety effects vivo. nanoparticles fabricated some specific chemicals, drugs, siRNA, display synergistic cancers. This paper comprehensively describes current status future perspectives AIEgens, showed a potential preclinical clinical translation on theranostics cancer.

Language: Английский

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Heavy Atom‐Free, Mitochondria‐Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real‐Time In‐Situ Therapeutic Monitoring

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(25)

Published: April 12, 2022

Abstract Based on spin‐orbit charge transfer intersystem crossing mechanism, two heavy‐atom‐free photosensitizers (PSs) BDP1 / BDP2 with absorption maxima at 506 nm/660 nm were constructed for photodynamic therapy (PDT). The long triplet state lifetimes and large singlet oxygen quantum yields, coupled the mitochondria‐targeted feature, made them highly phototoxic toward cancer cells. Moreover, PDT‐promoted cell apoptosis could be monitored by an obvious fluorescence off‐on response of PSs due to concomitant activation extensive mitophagy, thus facilitating timely therapeutic feedback avoid under‐ or over‐treatment. Importantly, such design allows activatable Glu‐BDP1 Glu‐BDP2 fabricated attaching γ‐glutamyl, a substrate γ‐glutamyltranspeptidase, alkoxyaniline unit , their ability in either selectively killing cells over normal ablating implanted tumour without damage healthy tissue was demonstrated.

Language: Английский

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