Technology Roadmap for Flexible Sensors

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5211 - 5295

Published: March 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Language: Английский

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Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review

Biosensors, Journal Year: 2020, Volume and Issue: 10(7), P. 79 - 79

Published: July 21, 2020

Biosensors devices have attracted the attention of many researchers across world. They capability to solve a large number analytical problems and challenges. are future ubiquitous for disease diagnosis, monitoring, treatment health management. This review presents an overview biosensors field, highlighting current research development bio-integrated implanted biosensors. These micro- nano-fabricated, according numerous techniques that adapted in order offer suitable mechanical match biosensor surrounding tissue, therefore decrease body's biological response. For this, most skin-integrated use polymer layer as versatile flexible structural support, combined with functional/active material, generate, transmit process obtained signal. A few challenging issues implantable devices, well strategies overcome them, also discussed this review, including response, power supply, data communication.

Language: Английский

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Highly-integrated, miniaturized, stretchable electronic systems based on stacked multilayer network materials

Science Advances, Journal Year: 2022, Volume and Issue: 8(11)

Published: March 16, 2022

Elastic stretchability and function density represent two key figures of merits for stretchable inorganic electronics. Various design strategies have been reported to provide both high levels density, but the densities are mostly below 80%. While stacked device layout can overcome this limitation, soft elastomers used in previous studies could highly restrict deformation interconnects. Here, we introduce multilayer network materials as a general platform incorporate individual components interconnects, without posing any essential constraint their deformations. Quantitative analyses show substantial enhancement (e.g., by ~7.5 times) elastic serpentine interconnects compared that based on elastomers. The proposed strategy allows demonstration miniaturized electronic system (11 mm 10 mm), with moderate (~20%) an unprecedented areal coverage (~110%), which serve compass display, somatosensory mouse, physiological-signal monitor.

Language: Английский

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Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization Methods

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(34)

Published: March 30, 2022

Bioelectronic implantable systems (BIS) targeting biomedical and clinical research should combine long-term performance biointegration in vivo. Here, recent advances novel encapsulations to protect flexible versions of such from the surrounding biological environment are reviewed, focusing on material strategies synthesis techniques. Considerable effort is put thin-film encapsulation (TFE), specifically organic-inorganic multilayer architectures as a conformal alternative conventional rigid cans. TFE direct contact with medium thus must exhibit not only biocompatibility, inertness, hermeticity but also mechanical robustness, conformability, compatibility manufacturing microfabricated devices. Quantitative characterization methods barrier reviewed particular emphasis water-vapor transmission rate through electrical, optical, or electrochemical principles. The integrability functionalization into functional bioelectronic interfaces discussed. represents must-have component for next-generation implants diagnostic therapeutic functions human healthcare precision medicine.

Language: Английский

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Robust Neural Interfaces with Photopatternable, Bioadhesive, and Highly Conductive Hydrogels for Stable Chronic Neuromodulation

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 885 - 895

Published: Jan. 11, 2023

A robust neural interface with intimate electrical coupling between electrodes and tissues is critical for stable chronic neuromodulation. The development of bioadhesive hydrogel a potential approach tightly fixing the on epineurium surface to construct interface. Herein, we photopatternable, antifouling, conductive (∼6 S cm–1), (interfacial toughness ∼100 J m–2), soft, elastic (∼290% strain, Young's modulus 7.25 kPa) establish bioelectronics. UV-sensitive zwitterionic monomer can facilitate formation an electrostatic-assembled polymer PEDOT:PSS network, it be further photo-cross-linked into network. Such semi-interpenetrating network endows good conductivity. Especially, photopatternable feature enables facile microfabrication processes multifunctional (MH) characteristic size 50 μm. MH electrodes, which show improved performance impedance, charge storage capacity, injection capability, produce effective stimulation high current density (1 mA cm–2) at ultralow voltages (±25 mV). could realize high-efficient communication recording sciatic nerve in rat model.

Language: Английский

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Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)

Published: Feb. 24, 2023

Abstract A critical challenge lies in the development of next‐generation neural interface, mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft multichannel interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities continuous high‐fidelity mapping signals biosafety active degrading performing functions. Such platform yields a high spatiotemporal resolution 1.42 ms 20 µm, signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish functional interfaces, designed as fully biodegradable electronic platforms vivo. Demonstrated applications such implants include real‐time monitoring electrical activities from cortical surface rats under various conditions (e.g., narcosis, epileptic seizure, electric stimuli) electrocorticography 100 channels. This technology offers general applicability great potential utility treatment/diagnosis neurological disorders.

Language: Английский

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Nucleic acid-based wearable and implantable electrochemical sensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7960 - 7982

Published: Jan. 1, 2024

This review discusses the advancements, sensor design, and challenges in creating wearable implantable nucleic acid-based sensors for personalized healthcare through real-time biomarker analysis biofluids.

Language: Английский

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Recent progress of soft and bioactive materials in flexible bioelectronics

Cyborg and Bionic Systems, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical chemical mismatch between implants ultimately results device failure corrosion by biofluids associated foreign body response. Of particular interest development of bioactive materials at level chemistry mechanics high-performance, minimally invasive function, simultaneously tissue-like compliance vivo biocompatibility. This review summarizes most recent progress these purposes, an emphasis on material properties such as response, integration schemes biological tissues, their use bioelectronic platforms. The article begins overview emerging classes platforms bio-integration proven utility live animal models, high performance different form factors. Subsequent sections various flexible, soft materials, ranging from self-healing hydrogel/elastomer bio-adhesive composites materials. Additional discussions highlight examples active systems support electrophysiological mapping, stimulation, drug delivery treatments related diseases, spatiotemporal resolutions span cellular organ-scale dimension. Envisioned applications involve advanced brain, cardiac, other organ systems, offer stability human subjects models. Results will inspire continuing advancements functions benign thus yielding therapy diagnostics healthcare.

Language: Английский

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Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(10)

Published: Nov. 9, 2021

Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical reliably and chronically interface can advance neuroscience, health monitoring, diagnostics, therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, soft electronic devices, advances in materials chemistry have emerged as fundamental creation next generation bioelectronics. This review summarizes contemporary forthcoming technical challenges related three principal components devices: i) substrates structural materials, ii) barrier encapsulation iii) conductive materials. Through notable illustrations from literature, integration device fabrication associated for each material class are highlighted.

Language: Английский

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Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Neuron, Journal Year: 2020, Volume and Issue: 108(2), P. 238 - 258

Published: Oct. 1, 2020

Language: Английский

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