3D Electrodes for Bioelectronics

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(47)

Published: May 19, 2021

Abstract In recent studies related to bioelectronics, significant efforts have been made form 3D electrodes increase the effective surface area or optimize transfer of signals at tissue–electrode interfaces. Although bioelectronic devices with 2D and flat electrode structures used extensively for monitoring biological signals, these planar it difficult biocompatible uniform interfaces nonplanar soft systems (at cellular tissue levels). Especially, biomedical applications expanding rapidly toward organoids deep tissues living animals, bioelectrodes are getting attention because they can reach regions various tissues. An overview on devices, such as use electrical stimulations recording neural from subjects, is presented. Subsequently, developments in materials fabrication processing micro‐ nanostructures introduced, followed by broad vitro vivo conditions.

Language: Английский

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Recent Advances on Hybrid Piezo-Triboelectric Bio-Nanogenerators: Materials, Architectures and Circuitry

Nanoenergy Advances, Journal Year: 2022, Volume and Issue: 2(1), P. 64 - 109

Published: Feb. 10, 2022

Nanogenerators, based on piezoelectric or triboelectric materials, have emerged in the recent years as an attractive cost-effective technology for harvesting energy from renewable and clean sources, but also human sensing biomedical wearable/implantable applications. Advances materials engineering enlightened new opportunities creation use of novel biocompatible soft well micro/nano-structured chemically-functionalized interfaces. Hybridization is a key concept that can be used to enhance performances single devices, by coupling more transducing mechanisms single-integrated micro-system. It has attracted plenty research interest due promising effects signal enhancement simultaneous adaptability different operating conditions. This review covers classifies main types hybridization piezo-triboelectric bio-nanogenerators it provides overview most advances terms material synthesis, applications, power-management circuits technical issues development reliable implantable devices. State-of-the-art applications fields harvesting, vitro/in vivo sensing, bioelectronics are outlined presented. The applicative perspectives challenges finally discussed, with aim suggest improvements design implementation next-generation hybrid biosensors.

Language: Английский

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Deployment of an electrocorticography system with a soft robotic actuator

Science Robotics, Journal Year: 2023, Volume and Issue: 8(78)

Published: May 10, 2023

Electrocorticography (ECoG) is a minimally invasive approach frequently used clinically to map epileptogenic regions of the brain and facilitate lesion resection surgery increasingly explored in brain-machine interface applications. Current devices display limitations that require trade-offs among cortical surface coverage, spatial electrode resolution, aesthetic, risk consequences often limit use mapping technology operating room. In this work, we report on scalable technique for fabrication large-area soft robotic arrays their deployment cortex through square-centimeter burr hole using pressure-driven actuation mechanism called eversion. The deployable system consists up six prefolded legs, it placed subdurally an aqueous pressurized solution secured pedestal rim small craniotomy. Each leg contains soft, microfabricated electrodes strain sensors real-time monitoring. proof-of-concept acute surgery, array was successfully deployed minipig record sensory activity. This neurotechnology opens promising avenues applications related neurological disorders such as motor deficits.

Language: Английский

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Intrinsically Antifouling, soft and conformal bioelectronic from scalable fabrication of Thin-Film OECT arrays by zwitterionic polymers

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 148980 - 148980

Published: Jan. 22, 2024

Language: Английский

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Biomimetic Exogenous “Tissue Batteries” as Artificial Power Sources for Implantable Bioelectronic Devices Manufacturing

Advanced Science, Journal Year: 2024, Volume and Issue: 11(11)

Published: Jan. 9, 2024

Implantable bioelectronic devices (IBDs) have gained attention for their capacity to conformably detect physiological and pathological signals further provide internal therapy. However, traditional power sources integrated into these IBDs possess intricate limitations such as bulkiness, rigidity, biotoxicity. Recently, artificial "tissue batteries" (ATBs) diffusely developed manufacturing, enabling comprehensive biological-activity monitoring, diagnosis, ATBs are on-demand designed accommodate the soft confining curved placement space of organisms, minimizing interface discrepancies, providing ample clinical applications. This review presents near-term advancements in ATBs, with a focus on miniaturization, flexibility, biodegradability, density. Furthermore, it delves material-screening, structural-design, energy density across three distinct categories TBs, distinguished by supply strategies. These types encompass innovative storage (chemical batteries supercapacitors), conversion that harness from human-body (biofuel cells, thermoelectric nanogenerators, bio-potential devices, piezoelectric harvesters, triboelectric devices), transfer receive utilize external (radiofrequency-ultrasound ultrasound-induced photovoltaic devices). Ultimately, future challenges prospects emphasize indispensability bio-safety, high-volume crucial components long-term implantable devices.

Language: Английский

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Multilayer stretchable electronics with designs enabling a compact lateral form

npj Flexible Electronics, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 21, 2024

Abstract Stretchable electronics are of huge interest as they can be useful in various irregular non-planar or deformable surfaces including human bodies. High density multi-functional stretchable beneficial reliably used more compact regions. However, simply stacking multiple layers may increase induced strain, reducing degree stretchability. Here, we present the design approach for multilayer that provide a similar stretchability compare to single layer although much form. We experimental and computational analyses benefits along with demonstrations form implantable bio-electronics passive matrix LEDs array. The results presented here should wide range applications require high-density electronics.

Language: Английский

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Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 10(3)

Published: Nov. 17, 2020

Abstract Research on the field of implantable electronic devices that can be directly applied in body with various functionalities is increasingly intensifying due to its great potential for therapeutic applications. While conventional electronics generally include rigid and hard conductive materials, their surrounding biological objects are soft dynamic. The mechanical mismatch between implanted environments induces damages especially long‐term Stretchable outstanding compliance effectively improve such limitations existing electronics. In this article, recent progress based nanocomposites systematically described. particular, representative fabrication approaches stretchable vivo applications focused on. To conclude, challenges perspectives current should considered further advances discussed.

Language: Английский

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Osseosurface electronics—thin, wireless, battery-free and multimodal musculoskeletal biointerfaces

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 18, 2021

Abstract Bioelectronic interfaces have been extensively investigated in recent years and advances technology derived from these tools, such as soft ultrathin sensors, now offer the opportunity to interface with parts of body that were largely unexplored due lack suitable tools. The musculoskeletal system is an understudied area where new technologies can result advanced capabilities. Bones a sensor stimulation location tremendous advantages for chronic biointerfaces because devices be permanently bonded provide stable optical, electromagnetic, mechanical impedance over course years. Here we introduce class wireless battery-free devices, named osseosurface electronics, which feature mechanics, ultra-thin form factor miniaturized multimodal comprised sensors optoelectronics directly adhered surface bone. Potential this fully implanted device demonstrated via real-time recording bone strain, millikelvin resolution thermography delivery optical freely-moving small animal models. Battery-free architecture, direct growth engineered calcium phosphate ceramic particles, demonstration operation deep tissue large models readout smartphone highlight characteristics exploratory research utility diagnostic therapeutic platform.

Language: Английский

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Compliant peripheral nerve interfaces

Journal of Neural Engineering, Journal Year: 2021, Volume and Issue: 18(3), P. 031001 - 031001

Published: March 8, 2021

Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which are responsible for conducting sensory-motor information to and from the central nervous system, regulating inner organs. PNIs used both in neuroscience research therapeutical applications such as precise closed-loop control neuroprosthetic limbs, treatment neuropathic pain restoration vital functions (e.g. breathing bladder management). Implantable represent an attractive solution directly access peripheral nerves provide enhanced selectivity recording stimulation, compared their non-invasive counterparts. Nevertheless, long-term functionality implantable is limited by tissue damage, occurs at implant-tissue interface, thus highly dependent on material properties, biocompatibility implant design. Current focuses development mechanically compliant PNIs, adapt anatomy dynamic movements body thereby limiting foreign response. In this paper, we review recent progress flexible highlighting promising solutions related materials selection associated fabrication methods, integrated functions. We report variety available interface designs (intraneural, extraneural regenerative) different modulation techniques (electrical, optical, chemical) emphasizing main challenges with integrating systems substrates.

Language: Английский

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MRI‐Compatible and Conformal Electrocorticography Grids for Translational Research

Advanced Science, Journal Year: 2021, Volume and Issue: 8(9)

Published: March 8, 2021

Intraoperative electrocorticography (ECoG) captures neural information from the surface of cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized electrodes embedded silicone rubber. Their mechanical rigidity fixed electrode spatial resolution are common shortcomings reported by surgical teams. Here, advances soft neurotechnology leveraged to manufacture conformable subdural, thin-film grids, evaluate their suitability translational research. Soft with 0.2 10 mm pitch diameter 150 µm membranes. The compatible handling can be folded safely interface hidden Sylvian fold human cadaveric models. It is found that conductor do not generate diagnostic-impeding imaging artefacts (<1 mm) nor adverse local heating within a standard 3T magnetic resonance scanner. Next, ability record subdural activity minipigs acutely two weeks postimplantation validated. Taken together, these results suggest promising future alternative current stiff may enable adoption research ultimately settings.

Language: Английский

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