Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(14)
Published: Jan. 6, 2022
Abstract
The
impermeable
barriers
of
solid
tumors
restrict
the
co‐delivery
protein‐based
drugs
and
chemotherapeutics
for
cancer
treatment.
Therefore,
we
developed
a
ZIF‐DOX/RA@DG
nanosystem
that
encapsulates
ribonuclease
A
(RA)
doxorubicin
(DOX)
in
zeolitic
imidazolate
framework
(ZIF‐8)
core,
with
dextran‐based
coating
(DG).
exhibits
dual‐responsiveness
due
to
γ‐glutamyl
transpeptidase‐activatable
cationization
acidic
microenvironment‐triggered
degradation.
DG‐coating
process
was
achieved
using
microfluidic
approach,
which
stabilized
polymer
responsiveness,
ZIF‐8‐based
structure,
bioactivity
encapsulated
therapeutics.
In
vivo
results
confirmed
could
co‐deliver
RA
DOX
deep
lesions
synergistic
anticancer
therapeutic
effects.
Such
multi‐drug
delivery
system
based
on
an
intelligent‐responsive
design
microfluidics‐assisted
synthesis
strategy
shows
great
clinical
prospects.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(22)
Published: April 19, 2021
Abstract
Polyphenols,
the
phenolic
hydroxyl
group‐containing
organic
molecules,
are
widely
found
in
natural
plants
and
have
shown
beneficial
effects
on
human
health.
Recently,
polyphenol‐containing
nanoparticles
attracted
extensive
research
attention
due
to
their
antioxidation
property,
anticancer
activity,
universal
adherent
affinity,
thus
great
promise
preparation,
stabilization,
modification
of
multifunctional
nanoassemblies
for
bioimaging,
therapeutic
delivery,
other
biomedical
applications.
Additionally,
metal−polyphenol
networks,
formed
by
coordination
interactions
between
polyphenols
metal
ions,
been
used
prepare
an
important
class
surface
modification,
drug
disease
treatments.
By
focusing
different
materials
(e.g.,
inorganic
materials,
polymers,
proteins,
nucleic
acids),
a
comprehensive
review
synthesis
properties
is
provided.
Moreover,
remarkable
versatility
applications,
including
biodetection,
multimodal
protein
gene
bone
repair,
antibiosis,
cancer
theranostics
also
demonstrated.
Finally,
challenges
faced
future
regarding
discussed.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(13), P. 2979 - 2992
Published: Jan. 1, 2021
Thermo-sensitive
hydrogels
based
on
different
polymers
have
been
broadly
used
in
the
pharmaceutical
fields.
In
this
review,
state-of-the-art
thermo-sensitive
for
drug
delivery
are
elaborated
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(4), P. 1327 - 1336
Published: Feb. 7, 2023
Deep
cutaneous
fungal
infection
(DCFI)
is
difficult
to
be
treated
by
the
traditional
topical
application
due
low
drug
transdermal
efficiency,
poor
fungicidal
effect,
and
easy
develop
resistance.
Here,
we
report
a
novel
biodegradable
microneedle
patch
(CuS/PAF-26
MN)
for
DCFI
treatment.
CuS/PAF-26
MN
composed
of
hyaluronic
acid
(HA)
sodium
carboxymethylcellulose
(CMC-Na),
which
can
simultaneously
deliver
copper
sulfide
nanoenzyme
(CuS
NE)
antimicrobial
peptide
(PAF-26).
CuS
NE
catalyzes
hydrogen
peroxide
produce
reactive
oxygen
species
(ROS),
PAF-26
directly
destroys
cell
membrane
fungi.
The
combination
ROS
toxicity
produced
destruction
shows
strong
antifungal
activities
without
effect
significantly
superior
that
ointment,
or
in
mouse
model.
Therefore,
promising
prospect
treating
DCFI.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(30)
Published: May 6, 2024
Abstract
The
high
level
of
lactate
in
tumor
microenvironment
not
only
promotes
development
and
metastasis,
but
also
induces
immune
escape,
which
often
leads
to
failures
various
therapy
strategies.
We
here
report
a
sono‐triggered
cascade
depletion
strategy
by
using
semiconducting
polymer
nanoreactors
(SPN
LCu
)
for
cancer
cuproptosis‐immunotherapy.
SPN
mainly
contain
as
sonosensitizer,
oxidase
(LOx)
conjugated
via
reactive
oxygen
species
(ROS)‐cleavable
linker
chelated
Cu
2+
.
Upon
ultrasound
(US)
irradiation,
the
generates
singlet
(
1
O
2
cut
ROS‐cleavable
allow
release
LOx
that
catalyzes
produce
hydrogen
peroxide
(H
).
will
be
reduced
+
microenvironment,
reacts
with
produced
H
obtain
hydroxyl
radical
(⋅OH)
further
improves
destroying
linkers.
As
such,
achieves
effective
depletion,
thus
relieving
immunosuppressive
roles
lactate.
Moreover,
toxic
cuproptosis
cause
immunogenic
cell
death
(ICD)
activating
antitumor
immunological
effect.
are
used
treat
both
subcutaneous
deep‐tissue
orthotopic
pancreatic
observably
enhanced
efficacy
restricting
growths.
This
study
provides
precise
tactic
therapy.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(6)
Published: Oct. 25, 2021
Abstract
Nanomedicines
have
the
potential
to
provide
advanced
therapeutic
strategies
in
combating
tumors.
Polymer‐prodrug‐based
nanomedicines
are
particularly
attractive
cancer
therapies
owing
maximum
drug
loading,
prolonged
blood
circulation,
and
reduced
premature
leakage
side
effects
comparison
with
conventional
nanomaterials.
However,
difficulty
precisely
tuning
composition
loading
of
polymer–drug
conjugates
leads
batch‐to‐batch
variations
prodrugs,
thus
significantly
restricting
their
clinical
translation.
Polyprodrug
inherit
numerous
intrinsic
advantages
exhibit
well‐controlled
via
direct
polymerization
monomers,
representing
a
promising
nanomedicine
for
tumor
therapies.
In
this
review,
recent
advances
development
polyprodrug
summarized
elimination.
Various
types
corresponding
properties
first
summarized.
The
unique
key
roles
various
further
highlighted.
Finally,
current
challenges
perspectives
on
future
research
discussed.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(18)
Published: July 29, 2021
Abstract
This
article
provides
a
broad
spectrum
about
the
nanoprodrug
fabrication
advances
co‐driven
by
prodrug
and
nanotechnology
development
to
potentiate
cancer
treatment.
The
inherits
features
of
both
concept
nanomedicine
know‐how,
attempts
solve
underexploited
challenge
in
treatment
cooperatively.
Prodrugs
can
release
bioactive
drugs
on‐demand
at
specific
sites
reduce
systemic
toxicity,
this
is
done
using
special
properties
tumor
microenvironment,
such
as
pH
value,
glutathione
concentration,
overexpressed
enzymes;
or
exogenous
stimulation,
light,
heat,
ultrasound.
nanotechnology,
manipulating
matter
within
nanoscale,
has
high
relevance
certain
biological
conditions,
been
widely
utilized
therapy.
Together,
marriage
strategy
which
shield
side
effects
parent
drug
with
pinpoint
delivery
capability
conceived
highly
camouflaged
Trojan
horse
maneuver
cancerous
threats.
